Results 81 to 90 of about 8,557 (169)
MedComm, Volume 7, Issue 3, March 2026.Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia +4 more
wiley +1 more source
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA
Cell Reports, 2016 The ataxia telangiectasia-mutated and Rad3-related (ATR) kinase checkpoint pathway maintains genome integrity; however, the role of the sirtuin 2 (SIRT2) acetylome in regulating this pathway is not clear.
Hui Zhang +22 more
doaj +1 more source
MedComm – Oncology, Volume 5, Issue 1, March 2026.In tamoxifen‐sensitive breast cancer, SIRT7 deacetylates ERα at lysines 302 and 303, promoting CHIP‐mediated, ubiquitin‐dependent proteasomal degradation of ERα and thereby restraining estrogen‐driven tumor growth. By contrast, during tamoxifen treatment, enhanced interaction between SIRT7 and ERα redirects deacetylated ERα toward activation of EGFR ...
Yalan Wu +14 more
wiley +1 more source
Frontiers in Immunology, 2019 Sirtuin 2 (SIRT2) and SIRT3 are cytoplasmic and mitochondrial NAD-dependent deacetylases. SIRT2 and SIRT3 target proteins involved in metabolic, proliferation and inflammation pathways and have been implicated in the pathogenesis of neurodegenerative ...
Tytti Heinonen +5 more
doaj +1 more source
Post‐translational regulation of human D‐3‐phosphoglycerate dehydrogenase in Alzheimer's disease
Protein Science, Volume 35, Issue 3, March 2026.Abstract Emerging evidence suggests that sex‐specific differences in L‐serine (L‐Ser) metabolism play a key role in Alzheimer's disease (AD). While disruptions in amino acid balance are well known, recent findings point to a dimorphic regulation of the serine biosynthetic pathway.
Elena Zerbini +5 more
wiley +1 more source
ODC1 Polyamine Metabolism Drives Prostate Cancer via AKT and Splicing
Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.ABSTRACT Prostate cancer is an aggressive disease with limited quantifiable biomarkers. One gene of interest is ODC1, which encodes ornithine decarboxylase, the rate‐limiting enzyme converting ornithine to putrescine in polyamine metabolism. Although ODC1 is known to be involved in prostate cancer development, exactly how it drives the disease ...
Jian Ma +6 more
wiley +1 more source
SIRT2 counteracts primate cardiac aging
Nature Aging, 2023 Laura Cox, Michael Olivier
openaire +2 more sources
Journal of Translational MedicineNAD-dependent deacetylase Sirt2 is involved in mammalian metabolic activities, matching energy demand with energy production and expenditure, and is relevant to a variety of metabolic diseases.
Jingru Guo +11 more
doaj +1 more source
Cancer Biology & Medicine, 2019 Objective As a member of the peptidyl arginine deiminase (PAD) family, PADI3 is weakly expressed in colon cancer tissues and highly expressed in adjacent colon cancer tissues. However, the role of PADI3 in colon cancer is unclear.
Xiaotian Chang +7 more
doaj +1 more source