Results 151 to 160 of about 84,834 (402)
Epigenetics and immunometabolism in diabetes and aging [PDF]
, 2018 Significance: A strong relationship between hyperglycemia, impaired insulin pathway and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation.
Cosentino, Francesco, Guzik, Tomasz J.
core +2 more sources
Regulation of metabolism by sirtuins [PDF]
BMC Proceedings, 2012 Mitochondrial sirtuins are NAD-dependent enzymes that bind and regulate numerous metabolic pathways within the mitochondria. For example, SIRT3 functions as an NAD-dependent deacetylase that binds and activates numerous oxidative pathways. We have discovered that sirtuins regulate metabolic pathways important in tumor cell metabolism.
openaire +4 more sources
European Journal of Heart Failure, EarlyView.Empagliflozin effects and heart failure outcomes in patients with heart failure with reduced ejection fraction and atrial fibrillation or sinus rhythm. AF, atrial fibrillation; CV, cardiovascular; eGFR, estimated glomerular filtration rate; HHF, hospitalization for heart failure; KCCQ, Kansas City Cardiomyopathy Questionnaire; SE, standard error ...
Michael Böhm +13 more
wiley +1 more source
Highlights of the Keystone Symposium: sirtuins in metabolism, aging and disease [PDF]
, 2012 From February 12–16, 2012, leading members of the sirtuin scientific community assembled in Tahoe, CA to attend the Keystone Symposium “Sirtuins in Aging, Metabolism, and Disease.” It was a vibrant and lively meeting, and in the spirit of Keystone ...
Kazanstev, Aleksey G +4 more
core +3 more sources
Food Frontiers, EarlyView.Metabolic syndrome is characterized by abdominal obesity, hyperglycemia, dyslipidemia, and hypertension. Bioactive compounds extracted from herbs, tea, and coffee using microbial cell factories, particularly resveratrol and caffeic acid, have demonstrated remarkable potential in the management of metabolic syndrome, offering innovative solutions for ...
Tao Li +7 more
wiley +1 more source
SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin
EMBO Molecular Medicine, 2013 Mesenchymal stem cells (MSCs) are multi‐potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. This potential declines with aging.
Petra Simic +9 more
doaj +1 more source
Periodicum biologorum, 2014 Sirtuins (SIRT) are group of enzymes that require nicotinamide adenine dinucleotide (NAD+) to catalyze their reactions. These chemical compounds have mono (ADP-ribosyl) transferase or deacetylases activities, and they can be found in nearly all species. The mammalian sirtuin family is described by seven proteins, namely.
KULIĆ, ANA +6 more
openaire +2 more sources
Sulfated Polysaccharides in the Hallmarks of Metabolic Syndrome: Functions and Mechanisms
Food Frontiers, EarlyView.The SPs sources are very diverse, including various fishes, sea cucumbers, seaweeds, etc. These SPs are able to improve the glucose and lipid metabolism disorders, hormonal dysregulation, oxidative stress, inflammatory response, complications, and gut homeostasis of MetS by regulating biochemical indicators related to MetS. ABSTRACT Metabolic syndrome (
Fuqiang Zhao +9 more
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Data in Brief, 2015 Expression of genes associated with inflammation was analyzed during differentiation of human pluripotent stem cells (PSCs) to hepatic cells. Messenger RNA transcript profiles of differentiated endoderm (day 5), hepatoblast (day 15) and hepatocyte-like ...
Joseph Ignatius Irudayam +10 more
doaj +1 more source