Results 171 to 180 of about 84,834 (402)

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity [PDF]

, 2013
The NAD+-dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies ...
Chen GL, Pattison D, Wang H, Yoshida M
core   +1 more source

Sirtuins: Sir2-related NAD-dependent protein deacetylases. [PDF]

, 2004
Brian J. North, Eric Verdin
openalex   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, EarlyView.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

Substrate-specific Activation of Sirtuins by Resveratrol [PDF]

, 2005
Matt Kaeberlein, Thomas McDonagh, Birgit Heltweg, Jeffrey Hixon, Eric A. Westman, Seth D. Caldwell, Andrew D. Napper, Rory Curtis, Peter S. DiStefano, Stanley Fields, Antonio Bedalov, Brian K. Kennedy   +11 more
openalex   +1 more source

Oxidative phosphorylation at the crossroads of cancer: Metabolic orchestration, stromal collusion, and emerging therapeutic horizons

Interdisciplinary Medicine, EarlyView.
Although most cancer cells rely on aerobic glycolysis, Oxidative phosphorylation (OXPHOS) remains essential for their survival, proliferation, and metastasis. With the emergence of OXPHOS‐targeted drugs, its therapeutic potential is becoming increasingly evident.
Keke Chen, Bo Wang, Hongying Shu, Jianxin Lyu, Wei Cui, Hezhi Fang   +5 more
wiley   +1 more source

Sirtuin E is a fungal global transcriptional regulator that determines the transition from the primary growth to the stationary phase [PDF]

, 2017
In response to limited nutrients, fungal cells exit the primary growth phase, enter the stationary phase, and cease proliferation. Although fundamental to microbial physiology in many environments, the regulation of this transition is poorly understood ...
Itoh Eriko, Masuo Shunsuke, Odakura Rika, Oinuma Ken-Ichi, Shimizu Motoyuki, Takaya Naoki, 桝尾 俊介, 高谷 直樹   +7 more
core   +2 more sources

Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD+ and Acetylated Peptide [PDF]

, 2006
Kevin G. Hoff, José L. Avalos‬, K. Sens, Cynthia Wolberger   +3 more
openalex   +1 more source

Persimmon carotenoid extract rich in β‐cryptoxanthin improves glucose homeostasis and reduces liver damage in high‐fat‐diet‐induced type 2 diabetic and metabolic dysfunction‐associated steatotic liver disease mice

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Background Persimmon (Diospyros kaki Thunb.) byproducts are a remarkable source of bioactive compounds, particularly carotenoids. Several studies suggest that carotenoids have beneficial effects in prevention of a large number of diseases. This study aims to highlight the effects of a persimmon carotenoid extract (PSCE) rich in β‐cryptoxanthin
Bryan Moreno‐Chamba, Nuria Martí, Antonio Cárdenas, María Soledad Fernández‐Pachón, Blanca Escudero‐López, Franz Martín, Julio Salazar‐Bermeo, Manuel Valero, Domingo Saura, María Concepción Martínez‐Madrid, Genoveva Berná   +10 more
wiley   +1 more source

Sirtuin-mediated nuclear differentiation and programmed degradation in Tetrahymena

BMC Cell Biology, 2011
Background The NAD+-dependent histone deacetylases, known as "sirtuins", participate in a variety of processes critical for single- and multi-cellular life.
Smith Joshua J, Cottrell Kyle A, Freggiaro Sydney, Slade Kristin M, Wiley Emily A   +4 more
doaj   +1 more source

Mitochondrial Function, Metabolic Regulation, and Human Disease Viewed through the Prism of Sirtuin 4 (SIRT4) Functions.

Journal of Proteome Research, 2019
As cellular metabolic hubs, mitochondria are the main energy producers for the cell. These organelles host essential energy producing biochemical processes, including the TCA cycle, fatty acid oxidation, and oxidative phosphorylation.
Cora N. Betsinger, I. Cristea
semanticscholar   +1 more source