Results 171 to 180 of about 87,529 (407)

The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver [PDF]

, 2019
Secreted frizzled-related protein (sFRP) 4 is an adipokine with increased expression in white adipose tissue from obese subjects with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).
Al-Hasani, Hadi, Barbosa, David, Fahlbusch, Pia, Herzfeld de Wiza, Daniella, Hörbelt, Tina, Knebel, Birgit, Kotzka, Jorg, Lapauw, Bruno, Müller-Wieland, Dirk, Ouwens, Margriet, Thoresen, G Hege, Van de Velde, Frederique, Van Nieuwenhove, Yves   +12 more
core   +1 more source

Clock gene dysregulation in epilepsy: A systematic review

Epilepsia Open, EarlyView.
Abstract Objective Epileptic seizures show a rhythmic pattern, being more frequent at particular times of the day (e.g., only occurring during sleep), suggesting a role of the circadian rhythm. Clock genes regulate the circadian rhythm and might be involved in the pathophysiology of epilepsy.
Guilherme Fernandes‐Campos, Arjune Sen, Francesca Panin, Krithika Sundararaman   +3 more
wiley   +1 more source

Regulation of the Mitogen Activated Protein Kinase Kinase (MEK)-1 by NAD-Dependent Deacetylases [PDF]

, 2014
Sirtuins are class III deacetylases that regulate many essential processes, including cellular stress, genome stability, and metabolism. Although these NAD+-dependent deacetylases control adaptive cellular responses, identification of sirtuin-regulated ...
A Duffy, A E Popko-Scibor, C S Ramsey, CL Brooks, CX Deng, D F Allison, D Li, DF Allison, E Verdin, ER Park, F Catalanotti, F Yeung, F Yeung, HS Kim, J A McCubrey, J Landry, JM Kyriakis, JS Smith, KA Resing, L G Gray, LR Saunders, M Kumar, M Li, M Shin, M W Mayo, MC Haigis, MC Lawrence, P Huang, PJ Roberts, RH Wang, S Giroux, S Imai, WL Blalock, X Xiao, Y Keshet   +34 more
core   +2 more sources

The role of sirtuin 1 and its activator, resveratrol in osteoarthritis

Bioscience Reports, 2019
Osteoarthitis (OA) is the most common aging-related joint pathology; the aging process results in changes to joint tissues that ultimately contribute to the development of OA. Articular chondrocytes exhibit an aging-related decline in their proliferative
Zhenhan Deng, Yusheng Li, Haifeng Liu, Shengshi Xiao, Liangjun Li, Jian Tian, Chao Cheng, Greg Zhang, Fangjie Zhang   +8 more
semanticscholar   +1 more source

Tocotrienols: A Review From Source to Therapeutic Applications

Food Frontiers, EarlyView.
Tocotrienols demonstrate superior antioxidant, neuroprotective, and anti‐inflammatory properties compared to conventional vitamin E forms, with promising therapeutic applications across multiple disorders when delivered through optimized systems that enhance their inherently limited bioavailability.
Natalia‐Carolina Londoño, Nidia Casas‐Forero, Andres‐Felipe Garzón‐Méndez, Dalí‐Aleixandra Rojas‐Díaz, Mary‐Luz Olivares‐Tenorio, Hernan‐Mauricio Romero, Jesús‐Alberto García‐Núñez   +6 more
wiley   +1 more source

Sirtuins: The Future Insight

Kathmandu University Medical Journal, 2013
Sirtuins are evolutionary conserved NAD+ dependent acetyl-lysine deacetylases and ADP ribosyltransferases dual-function enzymes involved in the regulation of metabolism and lifespan. Sirtuins represent a promising new class of III NAD dependent histone deacetylases that regulate a number of physiological processes, originally identified in yeast ...
openaire   +4 more sources

A pharmaco‐epistasis strategy reveals a new cell size controlling pathway in yeast

Molecular Systems Biology, 2013
Cell size is a complex quantitative trait resulting from interactions between intricate genetic networks and environmental conditions. Here, taking advantage of previous studies that uncovered hundreds of genes affecting budding yeast cell size ...
Fabien Moretto, Isabelle Sagot, Bertrand Daignan‐Fornier, Benoît Pinson   +3 more
doaj   +1 more source

Potential 14-3-3 binding sites in sirtuins reveal extended phosphosite-recognition modes. [PDF]

Acta Crystallogr F Struct Biol Commun
Identification, binding measurements and structure determination of human sirtuin phosphopeptides in complex with human adapter protein 14‐3‐3σ reveal variations among tight binders and suggest extended binding modes.The adapter proteins of the 14‐3‐3 family modulate the activity and/or localization of their binding partners, which they capture if a ...
Weyand M, Quast L, Steegborn C.
europepmc   +2 more sources

Highlights of the Keystone Symposium: sirtuins in metabolism, aging and disease [PDF]

, 2012
From February 12–16, 2012, leading members of the sirtuin scientific community assembled in Tahoe, CA to attend the Keystone Symposium “Sirtuins in Aging, Metabolism, and Disease.” It was a vibrant and lively meeting, and in the spirit of Keystone ...
Kazanstev, Aleksey G, Mai, Antonello, Maxwell, Michele M., Outeiro, Tiago F, Zaldivar-Jolissaint, Julien Francisco   +4 more
core   +3 more sources

Phloretin Suppresses Preadipocyte Differentiation by Targeting PPARγ/Transferrin to Activate Ferroptosis Signaling Pathway

Food Frontiers, EarlyView.
Phloretin alleviates HFD‐induced obesity and suppresses adipogenesis by activating the ferroptosis pathway, potentially via targeting PPARγ and transferrin. ABSTRACT Phloretin, a plant‐derived dihydrochalcone bioactive compound, potentially modulates preadipocyte differentiation, although this remains controversial and requires further clarification ...
Jie Li, Qihui Zhu, Yang Li, Haiyu Zhao, Yi Bi, Chuanying Pan, Min Wang, Lin Han, Xianyong Lan   +8 more
wiley   +1 more source