Results 251 to 260 of about 74,229 (355)

SRT2104 enhances dendritic outgrowth and spine formation through Sirtuin 1-mediated mTORC1 signaling. [PDF]

Sci Rep
Seo MK, Lee JG, Kim JH, Seog DH, Jeong S, Kim SH, Lee JY, Park SW.   +7 more
europepmc   +1 more source

Mitochondrial sirtuins, key regulators of aging [PDF]

Zhejun Ji, Guang‐Hui Liu, Jing Qu
openalex   +1 more source

Novel Roles for the Ectoenzyme CD38 in the Maintenance of Transcriptional and Metabolic Homeostasis in Astrocytes

Glia, Volume 74, Issue 2, February 2026.
CD38 deficiency influences brain NAD/NAM metabolism. Global CD38 deficiency drives changes in astrocyte mitochondrial, metabolic, senescence, and neurodegenerative‐related genes. CD38 deficiency alters glial reactivity and astrocyte bioenergetics. ABSTRACT CD38 is an ectoenzyme that converts NAD+ to NAM to help maintain bioenergetic homeostasis.
S. Basak, A. M. Colafrancesco, R. D. Hernandez, X. Wei, L. J. McMeekin, D. Dang, M. Simmons, J. L. Browning, K. Noel, F. Zhou, F. E. Lund, J. S. Saad, S. G. Watsen, A. M. Pickrell, R. M. Cowell, M. L. Olsen   +15 more
wiley   +1 more source

Role of SIRT3 in digestive system diseases and therapeutic prospects (Review). [PDF]

Int J Mol Med
Li J, Liu Q, Yao S, Li X, Zhang L, Wang Y, Wen G, An J, Jin H, Tuo B.   +9 more
europepmc   +1 more source

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao, Junjie Cheng, Yiming Zheng, Jing Wu, Jia Fan, Haixiang Sun, Chao Gao   +6 more
wiley   +1 more source

Evaluation of Copper-Induced Cytotoxicity and Transcriptomic Change Using a RTgill-W1 Cell Line as an Alternative Replacing Fish Test. [PDF]

Toxics
Lee JW, Shim I, Park K.
europepmc   +1 more source

Pulsed Electromagnetic Field Therapy for Mild‐to‐Moderate Knee Osteoarthritis: A Double‐Blind, Randomized, Placebo‐Controlled Clinical Trial

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Current treatments for knee osteoarthritis (OA) offer limited functional and structural improvements. Compared to age‐ and gender‐matched controls, patients with knee OA show a higher prevalence of muscle weakness, which negatively affects their ability to exercise—a key factor in enhancing physical mobility and delaying disease ...
Kenney Ki Lee Lau, Abbey Ssu Chi Chen, Christine Hoi Yan Fu, Jonathan Patrick Ng, Michael Tim Yun Ong, Patrick Shu Hang Yung, Pauline Po Yee Lui   +6 more
wiley   +1 more source

Correction: Mitochondrial impairment, decreased Sirtuin activity and protein acetylation in dorsal root ganglia in Friedreich ataxia models. [PDF]

Cell Mol Life Sci
Sanz-Alcázar A, Britti E, Delaspre F, Medina-Carbonero M, Pazos-Gil M, Tamarit J, Ros J, Cabiscol E.   +7 more
europepmc   +1 more source

Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren, Ziqi Shang, Alastair G. Stewart, Ying‐xin Qi, Kai Huang   +4 more
wiley   +1 more source

Interplay of oxidative stress and Inflammasome activation and clinical indices in Parkinson's disease: insights from serum SIRT1, Nrf2, and NLRP3 levels and PDQ-39-a cross-sectional study. [PDF]

Front Neurosci
Aldossary KM, Hamza E, Kamel MM, Alsegiani AS, Alrubia S, Sarawi WS, El-Khateeb E, Eltantawy N, Mourad SA, Elshorbagi N, Khrieba MO.   +10 more
europepmc   +1 more source