Results 41 to 50 of about 87,529 (407)

Biochemical Mechanisms of Sirtuin-Directed Protein Acylation in Hepatic Pathologies of Mitochondrial Dysfunction

Cells, 2022
Mitochondrial protein acetylation is associated with a host of diseases including cancer, Alzheimer’s, and metabolic syndrome. Deciphering the mechanisms regarding how protein acetylation contributes to disease pathologies remains difficult due to the ...
Courtney D. McGinnis, Erin Q. Jennings, Peter S. Harris, James J. Galligan, Kristofer S. Fritz   +4 more
doaj   +1 more source

Segmental aging underlies the development of a Parkinson phenotype in the AS/AGU rat [PDF]

, 2016
There is a paucity of information on the molecular biology of aging processes in the brain. We have used biomarkers of aging (SA β-Gal, p16Ink4a, Sirt5, Sirt6, and Sirt7) to demonstrate the presence of an accelerated aging phenotype across different ...
Khojah, Sohair M., McGuinness, Dagmara, Payne, Anthony P., Shields, Paul G.   +3 more
core   +2 more sources

Sirtuin 2 Regulates Protein LactoylLys Modifications

ChemBioChem, 2021
Post‐translational modifications (PTMs) play roles in both physiological and pathophysiological processes through the regulation of enzyme structure and function.
E. Jennings, Jason D. Ray, Christopher J. Zerio, Marissa N. Trujillo, D. M. McDonald, E. Chapman, D. Spiegel, J. Galligan   +7 more
semanticscholar   +1 more source

SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation

eLife, 2017
The Ras family of GTPases are important in cell signaling and frequently mutated in human tumors. Understanding their regulation is thus important for studying biology and human diseases.
Xiaoyu Zhang, Nicole A Spiegelman, Ornella D Nelson, Hui Jing, Hening Lin   +4 more
doaj   +1 more source

Contributions of a Histone Deacetylase (SirT2/Hst2) to Beauveria bassiana Growth, Development, and Virulence

Journal of Fungi, 2022
Sirtuins are a class of histone deacetylases that promote heterochromatin formation to repress transcription. The entomopathogenic fungus Beauveria bassiana contains six sirtuin homologs.
Qing Cai, Li Tian, Jia-Tao Xie, Dao-Hong Jiang, Nemat O. Keyhani   +4 more
doaj   +1 more source

Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells [PDF]

, 2018
Sirtuin 6 (SIRT6) is a member of the NAD+-dependent class III deacetylase sirtuin family, which plays a key role in cancer by controlling transcription, genome stability, telomere integrity, DNA repair, and autophagy.
Annamaria Biroccio, And, Del Bufalo, Donatella, Di Leo, Luca, Iachettini, Sara, Leonetti, Carlo, Lucidi, Alessia, Mai, Antonello, Rizzo, Angela, Rosa Ciriolo, Maria, Rotili, Dante, Salvati, Erica, Steegborn, Clemens, Trisciuoglio, Daniela, Zizza, Pasquale   +13 more
core   +2 more sources

Cardioprotective Effects of SIRT6 in a Mouse Model of Transverse Aortic Constriction-Induced Heart Failure

Frontiers in Physiology, 2017
SIRT6, a member of the NAD (+)-dependent class III deacetylase sirtuin family, plays important roles in the maintenance of cardiovascular homeostasis. Telomere shortening is a risk factor for age-associated diseases, including heart disease.
Yongming Li, Xianda Meng, Wenguang Wang, Fu Liu, Zhiru Hao, Yang Yang, Jinbo Zhao, Wensi Yin, Lijuan Xu, Ruiping Zhao, Ruiping Zhao, Jiang Hu   +11 more
doaj   +1 more source

Representation of probabilistic scientific knowledge [PDF]

, 2013
This article is available through the Brunel Open Access Publishing Fund. Copyright © 2013 Soldatova et al; licensee BioMed Central Ltd.The theory of probability is widely used in biomedical research for data analysis and modelling.
De Grave, K, King, RD, Rzhetsky, A, Soldatova, LN   +3 more
core   +1 more source

Cardioprotective Effects of Sirtuin-1 and Its Downstream Effectors

Circulation: Heart Failure, 2020
The cardioprotective effects of SGLT2 (sodium-glucose cotransporter 2) inhibitors may be related to their ability to induce a fasting-like paradigm, which triggers the activation of nutrient deprivation pathways to promote cellular homeostasis.
M. Packer
semanticscholar   +1 more source

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism [PDF]

Physiological Reviews, 2012
The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as cellular sensors to detect energy availability and modulate metabolic processes. Two sirtuins that are central to the control of metabolic processes are mammalian sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3), which are localized to the nucleus and mitochondria ...
Ruben, Nogueiras, Kirk M, Habegger, Nilika, Chaudhary, Brian, Finan, Alexander S, Banks, Marcelo O, Dietrich, Tamas L, Horvath, David A, Sinclair, Paul T, Pfluger, Matthias H, Tschöp   +9 more
openaire   +2 more sources