Results 51 to 60 of about 84,685 (258)
Neural Regeneration Research, 2021 In the peripheral nervous system, the activation of Sirtuin 1 can improve insulin resistance; however, the role played by Sirtuin 1 in the central nervous system remains unknown.
Hui Yang +5 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 Intestinal aging seriously affects the absorption of nutrients of the aged people. Ginsenoside Rb1 (GRb1) which has multiple functions on treating gastrointestinal disorders is one of the important ingredients from Ginseng, the famous herb in tradition ...
Zili Lei +14 more
doaj +1 more source
Effects of an Unusual Poison Identify a Lifespan Role for Topoisomerase 2 in Saccharomyces Cerevisiae [PDF]
, 2017 A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (yeast)
Baxter, Bonnie +13 more
core +2 more sources
International Journal of Molecular Sciences, 2021 Alternative splicing generates multiple distinct isoforms that increase transcriptome and proteome diversity. There are seven sirtuin genes in humans, each consists of multiple exons that are likely to undergo alternative splicing.
Xiaomin Zhang +3 more
semanticscholar +1 more source
Microbial Cell, 2016 Increasing the stability or dynamics of the actin cytoskeleton can extend lifespan in C. elegans and S. cerevisiae. Actin cables of budding yeast, bundles of actin filaments that mediate cargo transport, affect lifespan control through effects on ...
Ryo Higuchi-Sanabria +4 more
doaj +1 more source
The effects of graded levels of calorie restriction : XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome [PDF]
, 2017 We would like to acknowledge the BSU staff for their invaluable help with caring for the animals.Peer reviewedPublisher ...
Chen, Luonan +10 more
core +1 more source
New Insights for nicotinamide: Metabolic disease, autophagy, and mTOR
Frontiers in Bioscience-Landmark, 2020 Metabolic disorders, such as diabetes mellitus (DM), are increasingly becoming significant risk factors for the health of the global population and consume substantial portions of the gross domestic product of all nations. Although conventional therapies
Kenneth Maiese
doaj +1 more source
Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease [PDF]
, 2016 Background: Cigarette smoke induced oxidative stress has been shown to reduce silent information regulator 1 (Sirt1) levels in lung tissue from smokers and patients with COPD patients.
Akai, Masaya +11 more
core +2 more sources
Current Trends in Sirtuin Activator and Inhibitor Development
MoleculesSirtuins are NAD+-dependent protein deacylases and key metabolic regulators, coupling the cellular energy state with selective lysine deacylation to regulate many downstream cellular processes.
Karina L Bursch +2 more
semanticscholar +1 more source
The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases
Biomolecules, 2020 Chronic kidney disease (CKD) is one of the fastest growing causes of death worldwide, emphasizing the need to develop novel therapeutic approaches. CKD predisposes to acute kidney injury (AKI) and AKI favors CKD progression.
Miguel Fontecha-Barriuso +8 more
doaj +1 more source