Results 51 to 60 of about 74,229 (355)

Resveratrol and Resveratrol-Aspirin Hybrid Compounds as Potent Intestinal Anti-Inflammatory and Anti-Tumor Drugs

open access: yesMolecules, 2020
Resveratrol (3,4,5-Trihydroxy-trans-stilbene) is a naturally occurring polyphenol that exhibits beneficial pleiotropic health effects. It is one of the most promising natural molecules in the prevention and treatment of chronic diseases and autoimmune ...
Mohamed Salla   +12 more
doaj   +1 more source

Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis [PDF]

open access: yes, 2016
Funding The study was funded entirely by institutional funds.Peer ...
Galley, H. F.   +4 more
core   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

open access: yesHepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong   +9 more
wiley   +1 more source

Opportunities and Difficulties in the Repurposing of HDAC Inhibitors as Antiparasitic Agents

open access: yesDrugs and Drug Candidates
Ongoing therapy for human parasite infections has a few known drugs but with serious side effects and the problem of drug resistance, impelling us to discover novel drug candidates with newer mechanisms of action.
Tapas Kumar Mohapatra   +4 more
doaj   +1 more source

Antagonizing CD105 enhances radiation sensitivity in prostate cancer. [PDF]

open access: yes, 2018
Radiation therapy is the primary intervention for nearly half of the patients with localized advanced prostate cancer and standard of care for recurrent disease following surgery.
Andres, Allen   +9 more
core   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

open access: yesHepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso   +16 more
wiley   +1 more source

ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA

open access: yesCell Reports, 2016
The ataxia telangiectasia-mutated and Rad3-related (ATR) kinase checkpoint pathway maintains genome integrity; however, the role of the sirtuin 2 (SIRT2) acetylome in regulating this pathway is not clear.
Hui Zhang   +22 more
doaj   +1 more source

NAD+ Metabolism as an Emerging Therapeutic Target for Cardiovascular Diseases Associated With Sudden Cardiac Death

open access: yesFrontiers in Physiology, 2020
In addition to its central role in mediating oxidation reduction in fuel metabolism and bioenergetics, nicotinamide adenine dinucleotide (NAD+) has emerged as a vital co-substrate for a number of proteins involved in diverse cellular processes, including
Weiyi Xu, Le Li, Le Li, Lilei Zhang
doaj   +1 more source

Mitochondrial sirtuin 3 and various cell death modalities

open access: yesFrontiers in Cell and Developmental Biology, 2022
Sirtuin 3, a member of the mammalian sirtuin family of proteins, is involved in the regulation of multiple processes in cells. It is a major mitochondrial NAD+-dependent deacetylase with a broad range of functions, such as regulation of oxidative stress,
Maria A. Yapryntseva   +5 more
doaj   +1 more source

Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer [PDF]

open access: yes, 2013
Histone variants seem to play a major role in gene expression regulation. In prostate cancer, H2A.Z and its acetylated form are implicated in oncogenes’ upregulation.
Amado, Francisco   +8 more
core   +2 more sources

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