Results 1 to 10 of about 23,914,328 (286)
Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis [PDF]
iScienceSummary: Lysine lactylation (Kla), an epigenetic mark triggered by lactate during glycolysis, including the Warburg effect, bridges metabolism and gene regulation.
Runhua Du +13 more
doaj +5 more sources
Sirtuin 1 in Chronic Kidney Disease and Therapeutic Potential of Targeting Sirtuin 1
Frontiers in Endocrinology, 2022 The incidence and prevalence of chronic kidney disease (CKD) continue to increase worldwide remaining as a major public health burden. CKD eventually progresses to end-stage kidney failure and patients with CKD have high morbidity and mortality.
Jiayi Yan +3 more
doaj +4 more sources
The Role of Sirtuin 1 (SIRT1) in Neurodegeneration. [PDF]
Cureus, 2023 Sirtuins (SIRT) are a class of histone deacetylases that regulate important metabolic pathways and play a role in several disease processes. Of the seven mammalian homologs currently identified, sirtuin 1 (SIRT1) is the best understood and most studied ...
Razick DI +9 more
europepmc +4 more sources
Sirtuin 1 in Host Defense during Infection
Cells, 2022 Sirtuins (SIRTs) are members of the class III histone deacetylase family and epigenetically control multiple target genes to modulate diverse biological responses in cells. Among the SIRTs, SIRT1 is the most well-studied, with a role in the modulation of
Jin Kyung Kim +2 more
doaj +5 more sources
Sirtuin 1 in Endothelial Dysfunction and Cardiovascular Aging [PDF]
Frontiers in Physiology, 2021 Sirtuin 1 (SIRT1) is a histone deacetylase belonging to the family of Sirtuins, a class of nicotinamide adenine dinucleotide (NAD+)-dependent enzymes with multiple metabolic functions.
Stefano Ministrini +10 more
doaj +5 more sources
The Role of Sirtuin-1 (SIRT1) in the Physiology and Pathophysiology of the Human Placenta. [PDF]
Int J Mol Sci, 2023 Sirtuins, especially SIRT1, play a significant role in regulating inflammatory response, autophagy, and cell response to oxidative stress. Since their discovery, sirtuins have been regarded as anti-ageing and longevity-promoting enzymes.
Wątroba M, Szewczyk G, Szukiewicz D.
europepmc +2 more sources
Neural Regeneration Research, 2021 In the peripheral nervous system, the activation of Sirtuin 1 can improve insulin resistance; however, the role played by Sirtuin 1 in the central nervous system remains unknown.
Hui Yang +5 more
doaj +2 more sources
SRT2104 enhances dendritic outgrowth and spine formation through Sirtuin 1-mediated mTORC1 signaling [PDF]
Scientific ReportsImpaired neuroplasticity is a one of the key pathological mechanism of depression. Sirtuin 1 plays a crucial role in neuroplasticity; however, its precise mechanisms remain unclear.
Mi Kyoung Seo +7 more
doaj +2 more sources
Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging—A Systematic Review
Cells, 2021 Skin, as the outermost organ of the body, is constantly exposed to both intrinsic and extrinsic causative factors of aging. Intrinsic aging is related to compromised cellular proliferative capacity, and may be accelerated by harmful environmental ...
Angelika Bielach-Bazyluk +6 more
doaj +2 more sources
Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD [PDF]
Frontiers in EndocrinologyIntroductionSirtuin 1, a class III histone deacetylase, plays a critical role in the pathophysiology of both diabetes mellitus and bone metabolism by promoting osteoblast differentiation and inhibiting osteoclast maturation.
Yao Xu +11 more
doaj +2 more sources