Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis [PDF]
iScienceSummary: Lysine lactylation (Kla), an epigenetic mark triggered by lactate during glycolysis, including the Warburg effect, bridges metabolism and gene regulation.
Runhua Du +13 more
doaj +4 more sources
Sirtuin 1 in Chronic Kidney Disease and Therapeutic Potential of Targeting Sirtuin 1
Frontiers in Endocrinology, 2022 The incidence and prevalence of chronic kidney disease (CKD) continue to increase worldwide remaining as a major public health burden. CKD eventually progresses to end-stage kidney failure and patients with CKD have high morbidity and mortality.
Jiayi Yan +3 more
doaj +3 more sources
Expression of Sirtuin 1 and 2 Is Associated with Poor Prognosis in Non-Small Cell Lung Cancer Patients [PDF]
, 2015 Sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) are NAD+-dependent protein deacetylases involved in the regulation of key cancer-associated genes.
Agorreta, Jackeline +9 more
core +15 more sources
Association of sirtuin 1 rs10997868 and rs730821 polymorphisms with sirtuin 1 and hydroxy-2′-deoxyguanosine levels in healthy smokers: A case–control study [PDF]
Journal of International Medical ResearchObjectives This case–control study explored the association of sirtuin 1 polymorphisms (rs10997868 and rs730821) with metabolic parameters, smoking duration, sirtuin 1 levels, and the oxidative stress biomarker 8-hydroxy-2′-deoxyguanosine in healthy ...
Samar Sultan
doaj +2 more sources
SRT2104 enhances dendritic outgrowth and spine formation through Sirtuin 1-mediated mTORC1 signaling [PDF]
Scientific ReportsImpaired neuroplasticity is a one of the key pathological mechanism of depression. Sirtuin 1 plays a crucial role in neuroplasticity; however, its precise mechanisms remain unclear.
Mi Kyoung Seo +7 more
doaj +2 more sources
Plasma levels of sirtuin 1 and sirtuin 2 in ascending aortic aneurysm patients — a comparative study [PDF]
Cardiology JournalBACKGROUND: Studies of animal and human aortic tissue samples showed that sirtuins may protect against aortic aneurysm (AA). However, to date, no studies have assessed plasma or serum sirtuin levels in humans.
Jan Krekora +8 more
doaj +2 more sources
Renal Protective Effect of Sirtuin 1 [PDF]
Journal of Diabetes Research, 2014 Silent information regulator 2 (Sir2) is a nicotinamide adenine dinucleotide- (NAD+-) dependent deacetylase. The homology of SIRT1 and Sir2 has been extensively studied.
Yi-jun Dong +7 more
doaj +3 more sources
Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD [PDF]
Frontiers in EndocrinologyIntroductionSirtuin 1, a class III histone deacetylase, plays a critical role in the pathophysiology of both diabetes mellitus and bone metabolism by promoting osteoblast differentiation and inhibiting osteoclast maturation.
Yao Xu +11 more
doaj +2 more sources