Results 21 to 30 of about 23,914,328 (286)

Sirtuin-1 regulation of mammalian metabolism [PDF]

Trends in Molecular Medicine, 2010
Sirtuin-1 (SirT1) is a nutrient-sensing deacetylase whose levels and activity increase with caloric restriction to preserve euglycemia and promote efficient energy utilization. Focusing on data obtained in vivo, we review how SirT1 orchestrates the adaptive response to fasting by stimulating hepatic gluconeogenesis and fatty acid oxidation, increasing ...
Matthew P. Gillum, Derek M. Erion, Gerald I. Shulman   +2 more
openalex   +4 more sources

Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors [PDF]

International Journal of Molecular Sciences, 2021
Sirtuins (SIRTs) are NAD+-dependent deacetylases that regulate proliferation and cell death. In the human ovary, granulosa cells express sirtuin 1 (SIRT1), which has also been detected in human tumors derived from granulosa cells, i.e., granulosa cell tumors (GCTs), and in KGN cells.
Nina Schmid, Kim-Gwendolyn Dietrich, Ignasi Forne, Alexander Burges, Magdalena Szymanska, Rina Meidan, Doris Mayr, Artur Mayerhofer   +7 more
openaire   +2 more sources

Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1

Cellular and Molecular Life Sciences, 2021
Chronic disruption of circadian rhythms which include intricate molecular transcription-translation feedback loops of evolutionarily conserved clock genes has serious health consequences and negatively affects cardiovascular physiology. Sirtuins (SIRTs) are nuclear, cytoplasmic and mitochondrial histone deacetylases that influence the circadian clock ...
S. Soni, P. Basu, M. Singaravel, Ramaswamy Sharma, S. Pandi‑Perumal, D. Cardinali, R. Reiter   +6 more
semanticscholar   +5 more sources

Sirtuin 1 and endothelial glycocalyx [PDF]

Pflügers Archiv - European Journal of Physiology, 2020
AbstractSirtuin1 deficiency or reduced activity comprises one of the hallmarks of diseases as diverse as chronic cardiovascular, renal, and metabolic, some malignancies, and infections, as well as aging-associated diseases. In a mouse model of endothelium-limited defect in sirtuin 1 deacetylase activity, we found a dramatic reduction in the volume of ...
Lipphardt, Mark, Song, Jong Wook, Goligorsky, Michael S, Lipphardt, Mark; Department of Nephrology and Rheumatology, Göttingen University Medical Center, Georg August University, Göttingen, Germany, Song, Jong Wook; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea, Goligorsky, Michael S; Renal Research Institute, New York Medical College at the Touro University, Valhalla, USA   +5 more
openaire   +6 more sources

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism [PDF]

Physiological Reviews, 2012
The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as cellular sensors to detect energy availability and modulate metabolic processes. Two sirtuins that are central to the control of metabolic processes are mammalian sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3), which are localized to the nucleus and mitochondria ...
Paul T. Pfluger, Marcelo O. Dietrich, Brian Finan, David A. Sinclair, Alexander S. Banks, Nilika Chaudhary, Matthias H. Tschöp, Rubén Nogueiras, Kirk M. Habegger, Tamas L. Horvath   +9 more
openaire   +5 more sources

Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes

International Journal of Molecular Sciences, 2023
Type 2 diabetes (T2D) affects a large part of the adult population and impairs its quality of life. Because of this, natural compounds with antioxidant, anti-inflammatory and hypoglycemic properties have been used as adjuvants.
Beatriz Isabel García-Martínez, M. Ruiz-Ramos, J. Pedraza-Chaverri, E. Santiago-Osorio, V. Mendoza-Núñez   +4 more
semanticscholar   +1 more source

SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1

Cellular & Molecular Immunology, 2022
Most deaths from the COVID-19 pandemic are due to acute respiratory distress syndrome (ARDS)-related respiratory failure. Cytokine storms and oxidative stress are the major players in ARDS development during respiratory virus infections.
Shilei Zhang, Jingfeng Wang, Lulan Wang, Saba R. Aliyari, G. Cheng   +4 more
semanticscholar   +1 more source

Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43

Nature Communications, 2022
Trans-activation response DNA-binding protein of 43  kDa (TDP-43) regulates RNA processing and forms neuropathological aggregates in patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Jorge Garcia Morato, Friederike Hans, Felix von Zweydorf, R. Feederle, Simon J. Elsässer, Angelos A. Skodras, C. Gloeckner, E. Buratti, Manuela Neumann, P. Kahle   +9 more
semanticscholar   +1 more source

Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1

Cancer Communications, 2022
Mitochondria are dynamic organelles that constantly change their morphology through fission and fusion processes. Recently, abnormally increased mitochondrial fission has been observed in several types of cancer.
Dan Wu, Yi Yang, Yiran Hou, Zifeng Zhao, Ning Liang, P. Yuan, Tao Yang, J. Xing, Jibin Li   +8 more
semanticscholar   +1 more source

The role of sirtuin 1 on the induction of trained immunity [PDF]

Cellular Immunology, 2021
Sirtuin 1 (SIRT1) has been described to modify immune responses by modulation of gene transcription. As transcriptional reprogramming is the molecular substrate of trained immunity, a de facto innate immune memory, we investigated the role of SIRT1 in the induction of trained immunity. We identified various SIRT1 genetic single nucleotide polymorphisms
Mihai G. Netea, Simone J.C.F.M. Moorlag, L. Charlotte J. de Bree, Vera P. Mourits, Samuel T. Keating, Leo A. B. Joosten, Leo A. B. Joosten, Laszlo Groh, Martin Jaeger, Leonie Helder, Valerie A.C.M. Koeken, Charlotte D C C van der Heijden, Vasiliki Matzaraki, Jelmer H. van Puffelen   +13 more
openaire   +7 more sources