Results 111 to 120 of about 30,210 (302)

Getting old through the blood. Circulating molecules in aging and senescence of cardiovascular regenerative cells [PDF]

, 2017
Global aging is a hallmark of our century. The natural multifactorial process resulting in aging involves structural and functional changes, affecting molecules, cells, and tissues.
Angelini, Francesco, Bordin, Antonella, Chimenti, Isotta, De Falco, Elena, Pagano, Francesca, Picchio, Vittorio   +5 more
core   +2 more sources

Sirtuins: New Roles for Sirtuins in Aging and Disease [PDF]

Innovation in Aging, 2020
Abstract Sirtuins are NAD+-dependent enzymes related to yeast silent information regulator-2, a histone deacetylase that prevents premature aging through chromatin silencing. Mammalian sirtuins, SIRT1-SIRT7, have key functions that protect against diverse aging-related pathologic states, from cancer to metabolic and neurodegenerative ...
openaire   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Sirtuin-mediated nuclear differentiation and programmed degradation in Tetrahymena [PDF]

, 2011
BackgroundThe NAD+-dependent histone deacetylases, known as "sirtuins", participate in a variety of processes critical for single- and multi-cellular life.
Kristin M Slade, Sydney Freggiaro, Kyle A Cottrell, Joshua J Smith, Emily A Wiley   +4 more
core   +2 more sources

Nutrition, sirtuins and aging [PDF]

Genes & Nutrition, 2006
Beyond our inherited genetic make-up environmental factors are central for health and disease and finally determine our life span. Amongst the environmental factors nutrition plays a prominent role in affecting a variety of degenerative processes that are linked to aging.
openaire   +2 more sources

Dihydroquinazolinones by Titanocene‐Catalyzed Reductive Radical Addition to Quinazolinones

Chemistry – A European Journal, EarlyView.
Tri‐ and tetracyclic dihydroquinazolinones or quinazolinones by titanocene catalysis: A highly diastereoselective and efficient reductive radical addition to quinazolinones enables an unprecedented entry to pharmaceutically relevant dihydroquinazolinones by avoiding the interception of radical intermediates prior to the slow radical addition.
Thomas Heinrichs, Fabian Lang, Konstantin Woitol, Jana Vohn, Andreas Schneider, Andreas Gansäuer   +5 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Mammalian Sirtuins and Energy Metabolism

International Journal of Biological Sciences, 2011
Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerged as
Xiaoling Li, Nevzat Kazgan
doaj  

The dual role of sirtuins in cancer: biological functions and implications

Frontiers in Oncology
Sirtuins are pivotal in orchestrating numerous cellular pathways, critically influencing cell metabolism, DNA repair, aging processes, and oxidative stress. In recent years, the involvement of sirtuins in tumor biology has garnered substantial attention,
Lu Yu, Yanjiao Li, Siyuan Song, Yalin Zhang, Yalin Zhang, Yiping Wang, Hailian Wang, Zhengteng Yang, Yi Wang, Yi Wang   +9 more
doaj   +1 more source