Results 101 to 110 of about 22,350 (290)
The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle
ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley +1 more source
Sirtuin family in lung adenocarcinoma
Discover OncologyLung cancer is a highly aggressive malignancy that accounts for one of the greatest mortality rate in humans globally. Among various types of lung malignancies, lung adenocarcinoma (LUAD) stands out as the most common form. Sirtuins (SIRTs) are class III
Cui Chen +5 more
doaj +1 more source
Sirtuins, Aging, and Metabolism [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2011 Sirtuins are nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases that link protein acetylation, metabolism, aging, and diseases of aging. Sirtuins were initially found to slow aging in lower organisms and more recently shown to mediate many effects of calorie restriction on metabolism and longevity in mammals. This chapter focuses on
openaire +2 more sources
A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation
Food Chemistry International, EarlyView.Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee +4 more
wiley +1 more source
The dual role of sirtuins in cancer: biological functions and implications
Frontiers in OncologySirtuins are pivotal in orchestrating numerous cellular pathways, critically influencing cell metabolism, DNA repair, aging processes, and oxidative stress. In recent years, the involvement of sirtuins in tumor biology has garnered substantial attention,
Lu Yu +9 more
doaj +1 more source
Sirtuins and Pyridine Nucleotides [PDF]
Circulation Research, 2012 The silencer information regulator (Sir) family of proteins has attracted much attention during the past decade due to its prominent role in metabolic homeostasis in mammals. The Sir1–4 proteins were first discovered in yeast as nicotinamide adenine dinucleotide (NAD + )-dependent deacetylases, which through a gene ...
openaire +2 more sources
Mechanisms and Molecular Probes of Sirtuins [PDF]
, 2008 Sirtuins are critical regulators of many cellular processes, including insulin secretion, the cell cycle, and apoptosis. Sirtuins are associated with a variety of age-associated diseases such as type II diabetes, obesity, and Alzheimer's disease.
Smith, Brian C. +2 more
core +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Sirtuins in Aging and Disease [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2007 Sirtuin genes function as anti-aging genes in yeast, Caenorhabditis elegans, and Drosophila. The NAD requirement for sirtuin function indicates a link between aging and metabolism, and a boost in sirtuin activity may in part explain how calorie restriction extends life span.
openaire +2 more sources
The role of sirtuins in Alzheimer’s Disease [PDF]
, 2013 Sirtuins are highly conserved NAD+-dependent enzymes that were shown to have beneficial effects against age-related diseases. Alzheimer’s Disease (AD) is the most common neurodegenerative disorder associated with aging and the effects of sirtuins on AD ...
Rakhee eLalla +3 more
core +1 more source