Results 81 to 90 of about 18,502 (257)
Mammalian Sirtuins and Energy Metabolism
International Journal of Biological Sciences, 2011 Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerged as
Xiaoling Li, Nevzat Kazgan
doaj
International Journal for Parasitology: Drugs and Drug ResistanceAlbendazole resistance in Giardia duodenalis includes a complex and multifactorial challenge that potentially involves non-reported pathways such as the participation of metabolic regulators.
Adrián Chávez-Cano +2 more
doaj +1 more source
Nutrition, sirtuins and aging [PDF]
Genes & Nutrition, 2006 Beyond our inherited genetic make-up environmental factors are central for health and disease and finally determine our life span. Amongst the environmental factors nutrition plays a prominent role in affecting a variety of degenerative processes that are linked to aging.
openaire +2 more sources
Flavour and Fragrance Journal, EarlyView.This study demonstrates that resveratrol alleviates allergic rhinitis by activating SIRT1, thereby disrupting the mitochondrial ROS‐inflammatory cycle, improving mitochondrial function, promoting anti‐inflammatory M2 macrophage polarisation, and reducing epithelial oxidative damage.
Xinyu Zhou +6 more
wiley +1 more source
Food Biomacromolecules, EarlyView.Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley +1 more source
Sirtuin family in lung adenocarcinoma
Discover OncologyLung cancer is a highly aggressive malignancy that accounts for one of the greatest mortality rate in humans globally. Among various types of lung malignancies, lung adenocarcinoma (LUAD) stands out as the most common form. Sirtuins (SIRTs) are class III
Cui Chen +5 more
doaj +1 more source
The dual role of sirtuins in cancer: biological functions and implications
Frontiers in OncologySirtuins are pivotal in orchestrating numerous cellular pathways, critically influencing cell metabolism, DNA repair, aging processes, and oxidative stress. In recent years, the involvement of sirtuins in tumor biology has garnered substantial attention,
Lu Yu +9 more
doaj +1 more source
Kathmandu University Medical Journal, 2013 Sirtuins are evolutionary conserved NAD+ dependent acetyl-lysine deacetylases and ADP ribosyltransferases dual-function enzymes involved in the regulation of metabolism and lifespan. Sirtuins represent a promising new class of III NAD dependent histone deacetylases that regulate a number of physiological processes, originally identified in yeast ...
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Sirtuins in Aging and Disease [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2007 Sirtuin genes function as anti-aging genes in yeast, Caenorhabditis elegans, and Drosophila. The NAD requirement for sirtuin function indicates a link between aging and metabolism, and a boost in sirtuin activity may in part explain how calorie restriction extends life span.
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Assaying Chromatin Sirtuins [PDF]
, 2013 Most of the sirtuins' nuclear substrates identified so far are histones or other chromatin-associated proteins and, thus, it is of special relevance the development of good biochemical techniques to analyze the biology of these proteins in the context of chromatin.
Zhong, Lei +4 more
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