Results 71 to 80 of about 22,350 (290)

Role of sirtuins in obesity and osteoporosis: molecular mechanisms and therapeutic targets

Cell Communication and Signaling
The prevalence of obesity and osteoporosis (OP) represents a significant public health concern on a global scale. A substantial body of evidence indicates that there is a complex relationship between obesity and OP, with a correlation between the ...
Yikuan Du, Yuying Huo, Yujia Yang, Peiqi Lin, Wuzheng Liu, Ziqin Wang, Wenqi Zeng, Jiahui Li, Zhonghan Liang, Chenyue Yuan, Jinfeng Zhu, Ziyi Luo, Yi Liu, Chunling Ma, Chun Yang   +14 more
doaj   +1 more source

Sirtuin activators as an anti-aging intervention for longevity [PDF]

Exploration of Drug Science
Sirtuins are a family of NAD+-dependent class III histone deacetylases that regulate histones and other proteins. The mammalian sirtuins comprise seven members that have a role in energy metabolism, DNA repair, inflammation, cell survival, apoptosis ...
Puja Sah, Anita K. Rai, Donkupar Syiem
doaj   +1 more source

SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases

Frontiers in Pharmacology, 2021
Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins.
Ramu Manjula, Kumari Anuja, Francisco J. Alcain, Francisco J. Alcain   +3 more
doaj   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

The Role of Sirtuins in Kidney Diseases

, 2020
Sirtuins (SIRTs) are class III histone deacetylases (HDACs) that play important roles in aging and a wide range of cellular functions. Sirtuins are crucial to numerous biological processes, including proliferation, DNA repair, mitochondrial energy ...
Minjee Jo, Yu Ah Hong, Ji Eun Kim, Gang-Jee Ko   +3 more
core   +1 more source

Dethioacylation by Sirtuins 1–3: Considerations for Drug Design using Mechanism-based Sirtuin Inhibition [PDF]

, 2019
The sirtuin enzymes are potential drug targets for intervention in a series of diseases. Efforts to inhibit enzymes of this class with thioamide- and thiourea-containing, substrate-mimicking entities have produced a number of high-affinity binders ...
Nima, Rajabi, Christian Adam Olsen (7873415), Christian Adam, Olsen, Rajabi, Nima, Olsen, Christian Adam, Alexander Lund Nielsen (8100299), Nielsen, Alexander Lund, Alexander, Lund Nielsen, Nima Rajabi (8100297)   +8 more
core   +2 more sources

Arabidopsis thaliana sirtuins control proliferation and glutamate dehydrogenase activity [PDF]

, 2023
Sirtuins are part of a gene family of NAD-dependent deacylases that act on histone and non-histone proteins and control a variety of activities in all living organisms. Their roles are mainly related to energy metabolism and include lifetime regulation,
Michele Saliola, Gianmarco Pascarella, Veronica Morea, Sabrina Venditti, Maria Luisa Mauro, Angelo De Paolis, Cristina Maria Failla, Patrizio Di Micco, Giovannella Bruscalupi   +8 more
core   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Sirtuins, Aging, and Medicine

, 2019
Sirtuins were originally identified as antiaging proteins in model genetic organisms and have emerged as mediators of the beneficial effects of calorie restriction in mammals.
Guarente, Leonard Pershing
core   +1 more source