Results 51 to 60 of about 30,210 (302)
Effect of breed on the expression of Sirtuins (Sirt1-7) and antioxidant capacity in porcine brain
Animal, 2013 Sirtuins, NAD-dependent histone deacetylase (HDAC), are correlated to aging and antioxidant. The aim of this study was to determine breed differences of porcine Sirtuins expression and antioxidant capacity in brain between Jinhua pigs (a fatty breed of ...
Y. Ren +5 more
doaj +1 more source
Translational Medicine of Aging, 2021 Caloric restriction (CR) is considered one of the most efficient interventions that extend lifespan and healthspan by delaying the onset of many age-related diseases in a variety of organisms.
Martin Maldonado +5 more
doaj +1 more source
Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. [PDF]
, 2012 Sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs), NAD(+)-dependent enzymes, link cellular energy status with responses to environmental stresses.
Benavente, Claudia A +2 more
core +3 more sources
Oncometabolic role of mitochondrial sirtuins in glioma patients.
PLoS ONE, 2023 Mitochondrial sirtuins have diverse role specifically in aging, metabolism and cancer. In cancer, these sirtuins play dichotomous role as tumor suppressor and promoter.
Maria Fazal Ul Haq +7 more
doaj +2 more sources
Frontiers in Neuroscience, 2020 Neurodegeneration of the central and enteric nervous systems is a common feature of aging and aging-related diseases, and is accelerated in individuals with metabolic dysfunction including obesity and diabetes.
Pavithra Chandramowlishwaran +9 more
doaj +1 more source
Sirt5 Inhibits BmNPV Replication by Promoting a Relish-Mediated Antiviral Pathway in Bombyx mori
Frontiers in Immunology, 2022 Silent information regulators (Sirtuins) belong to the family of nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases (HDACs) that have diverse functions in cells.
Mengmeng Zhang +9 more
doaj +1 more source
The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer. [PDF]
, 2020 The gut barrier separates trillions of microbes from the largest immune system in the body; when compromised, a "leaky" gut barrier fuels systemic inflammation, which hastens the progression of chronic diseases.
Das, Soumita +9 more
core +3 more sources
Sirtuin Modulators in Cellular and Animal Models of Human Diseases
Frontiers in Pharmacology, 2021 Sirtuins use NAD+ to remove various acyl groups from protein lysine residues. Through working on different substrate proteins, they display many biological functions, including regulation of cell proliferation, genome stability, metabolism, and cell ...
Jun Young Hong, Hening Lin, Hening Lin
doaj +1 more source
G3: Genes, Genomes, Genetics, 2016 Sirtuins are evolutionarily conserved NAD-dependent deacetylases that catalyze the cleavage of NAD+ into nicotinamide (NAM), which can act as a pan-sirtuin inhibitor in unicellular and multicellular organisms.
John S. Choy +5 more
doaj +1 more source
Why do bilaterally symmetrical flowers orient vertically? Flower orientation influences pollinator landing behaviour [PDF]
, 2005 Protein lysine posttranslational modification by an increasing number of different acyl groups is becoming appreciated as a regulatory mechanism in cellular biology. Sirtuins are class III histone deacylases that use NAD(+) as a co-substrate during amide
Andersen, Christian +11 more
core +1 more source