Results 31 to 40 of about 22,350 (290)
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source
Hepatology, EarlyView., 2022 NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger +7 more
wiley +1 more source
The Contentious History of Sirtuin Debates
Rambam Maimonides Medical Journal, 2012 The sirtuins are highly conserved enzyme homologues of the yeast Sir2, with activities of NAD+ dependent deacetylase and/or mono ADP ribosyltransferase.
Shoshana Naiman, Haim Y. Cohen
doaj +1 more source
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism [PDF]
Physiological Reviews, 2012 The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as cellular sensors to detect energy availability and modulate metabolic processes. Two sirtuins that are central to the control of metabolic processes are mammalian sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3), which are localized to the nucleus and mitochondria ...
Ruben, Nogueiras +9 more
openaire +2 more sources
Expression of Sirtuins in the Retinal Neurons of Mice, Rats, and Humans
Frontiers in Aging Neuroscience, 2017 Sirtuins are a class of histone deacetylases (HDACs) that have been shown to regulate a range of pathophysiological processes such as cellular aging, inflammation, metabolism, and cell proliferation. There are seven mammalian Sirtuins (SIRT1-7) that play
Hongdou Luo +7 more
doaj +1 more source
Retinal Aging and Sirtuins [PDF]
Ophthalmic Research, 2010 The process of aging involves the accumulating changes in the microenvironment that lead to cell senescence or apoptosis, and subsequent tissue or organ dysfunction. Multiple extrinsic and intrinsic events that cause DNA instability are associated with aging.
Yoko, Ozawa +6 more
openaire +2 more sources
Frontiers in Oncology, 2020 Sirtuins, class III histone deacetylases, are involved in multiple biological processes in cancer initiation and progression. However, the diverse expression patterns and prognostic values of sirtuins in cancers have yet to be elucidated.
Ying Tan +4 more
doaj +1 more source
Sirtuins: Sir2-related NAD-dependent protein deacetylases [PDF]
, 2004 Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases dependent on nicotine adenine dinucleotide (NAD) and are found in organisms ranging from bacteria to humans. In eukaryotes, sirtuins regulate transcriptional repression,
North, Brian J, Verdin, Eric
core +1 more source
Sirtuins—The New Important Players in Women’s Gynecological Health
Antioxidants, 2021 The participation of sirtuins in the regulation of oxidative stress and inflammation lies at the basis of their possible modes of action and is related to their expression in various cell structures; their location in the mitochondria and blood plasma ...
Ewa Maria Kratz +3 more
doaj +1 more source
Regulation of sirtuin function by posttranslational modifications
Frontiers in Pharmacology, 2012 Sirtuins are homologs of the yeast silencing information regulator 2 (Sir2) protein, an NAD+-dependent (histone) deacetylase. In mammals 7 different sirtuins, SIRT1-7, have been identified, which share a common catalytic core domain but possess distinct ...
Franziska eFlick, Bernhard eLüscher
doaj +1 more source