Results 31 to 40 of about 18,502 (257)
Frontiers in Oncology, 2020 Sirtuins, class III histone deacetylases, are involved in multiple biological processes in cancer initiation and progression. However, the diverse expression patterns and prognostic values of sirtuins in cancers have yet to be elucidated.
Ying Tan +4 more
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Sirtuins—The New Important Players in Women’s Gynecological Health
Antioxidants, 2021 The participation of sirtuins in the regulation of oxidative stress and inflammation lies at the basis of their possible modes of action and is related to their expression in various cell structures; their location in the mitochondria and blood plasma ...
Ewa Maria Kratz +3 more
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Regulation of sirtuin function by posttranslational modifications
Frontiers in Pharmacology, 2012 Sirtuins are homologs of the yeast silencing information regulator 2 (Sir2) protein, an NAD+-dependent (histone) deacetylase. In mammals 7 different sirtuins, SIRT1-7, have been identified, which share a common catalytic core domain but possess distinct ...
Franziska eFlick, Bernhard eLüscher
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Frontiers in Cardiovascular Medicine, 2022 Vascular calcification (VC) is a common pathological change in many chronic diseases, such as diabetes and chronic kidney disease. It is mainly deposited in the intima and media of vessels in the form of hydroxyapatite.
Shuangshuang Wang, Siwang Hu
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Effect of breed on the expression of Sirtuins (Sirt1-7) and antioxidant capacity in porcine brain
Animal, 2013 Sirtuins, NAD-dependent histone deacetylase (HDAC), are correlated to aging and antioxidant. The aim of this study was to determine breed differences of porcine Sirtuins expression and antioxidant capacity in brain between Jinhua pigs (a fatty breed of ...
Y. Ren +5 more
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Sirtuin Modulators in Cellular and Animal Models of Human Diseases
Frontiers in Pharmacology, 2021 Sirtuins use NAD+ to remove various acyl groups from protein lysine residues. Through working on different substrate proteins, they display many biological functions, including regulation of cell proliferation, genome stability, metabolism, and cell ...
Jun Young Hong, Hening Lin, Hening Lin
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Frontiers in Neuroscience, 2020 Neurodegeneration of the central and enteric nervous systems is a common feature of aging and aging-related diseases, and is accelerated in individuals with metabolic dysfunction including obesity and diabetes.
Pavithra Chandramowlishwaran +9 more
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Oncometabolic role of mitochondrial sirtuins in glioma patients.
PLoS ONE, 2023 Mitochondrial sirtuins have diverse role specifically in aging, metabolism and cancer. In cancer, these sirtuins play dichotomous role as tumor suppressor and promoter.
Maria Fazal Ul Haq +7 more
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G3: Genes, Genomes, Genetics, 2016 Sirtuins are evolutionarily conserved NAD-dependent deacetylases that catalyze the cleavage of NAD+ into nicotinamide (NAM), which can act as a pan-sirtuin inhibitor in unicellular and multicellular organisms.
John S. Choy +5 more
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Sirtuins at the Service of Healthy Longevity
Frontiers in Physiology, 2021 Sirtuins may counteract at least six hallmarks of organismal aging: neurodegeneration, chronic but ineffective inflammatory response, metabolic syndrome, DNA damage, genome instability, and cancer incidence.
Mateusz Watroba, Dariusz Szukiewicz
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