Results 11 to 20 of about 22,350 (290)

Sirtuins, Metabolism and Cancer [PDF]

Frontiers in Pharmacology, 2012
More than a decade ago, sirtuins were discovered as a highly conserved family of NAD+-dependent enzymes that extend lifespan in lower organisms. In mammals, sirtuins are key regulators of stress responses and metabolism, influencing a range of diseases ...
Barbara eMartinez-Pastor, Raul eMostoslavsky   +1 more
doaj   +9 more sources

Sirtuins, Bioageing, and Cancer [PDF]

Journal of Aging Research, 2011
The Sirtuins are a family of orthologues of yeast Sir2 found in a wide range of organisms from bacteria to man. They display a high degree of conservation between species, in both sequence and function, indicative of their key biochemical roles. Sirtuins
D. McGuinness, D. H. McGuinness, J. A. McCaul, P. G. Shiels   +3 more
doaj   +6 more sources

Roles of sirtuins in asthma

Respiratory Research, 2022
Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacylases and deacetylases that participate in a variety of cellular processes, including transcriptional activity, energy metabolism, DNA damage response, inflammation, apoptosis ...
Yahui Liu, Guochao Shi
doaj   +3 more sources

Sirtuins and Insulin Resistance [PDF]

Frontiers in Endocrinology, 2018
The mammalian Sirtuins (SIRT1-7) are an evolutionarily conserved family of NAD+-dependent deacylase and mono-ADP-ribosyltransferase. Sirtuins display distinct subcellular localizations and functions and are involved in cell survival, senescence ...
Shuang Zhou, Xiaoqiang Tang, Hou-Zao Chen   +2 more
doaj   +2 more sources

Sirtuins and their interactions with transcription factors and poly(ADP-ribose) polymerases [PDF]

Folia Neuropathologica, 2016
Sirtuins (SIRT1 to -7) are unique histone deacetylases (HDACs) whose activity depends on NAD+, thus making them capable of sensing the cellular metabolic status.
Henryk Jęśko, Robert P. Strosznajder
doaj   +2 more sources

The substrate specificity of sirtuins.

Annual Review of Biochemistry, 2016
Sirtuins are NAD(+)-dependent enzymes universally present in all organisms, where they play central roles in regulating numerous biological processes.
Lin, H., Jing, H., Bheda, P., Wolberger, C.   +3 more
core   +4 more sources

Roles of Sirtuins in Hearing Protection

Pharmaceuticals
Hearing loss is a health crisis that affects more than 60 million Americans. Currently, sodium thiosulfate is the only drug approved by the Food and Drug Administration (FDA) to counter hearing loss.
Chail Koo, Claus-Peter Richter, Xiaodong Tan   +2 more
doaj   +3 more sources

Sirtuins

, 2021
Sirtuins are involved in numerous biological processes such as cell survival and metabolism, aging, and DNA repair; thus they modulate crucial metabolic pathways.
Zwergel, Clemens, Mai, Antonello, Clemens Zwergel, Antonello Mai, Daniela Tomaselli, Tomaselli, Daniela   +5 more
core   +2 more sources

SnapShot: Mammalian Sirtuins [PDF]

Cell, 2014
The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan.
Hirschey, Matthew D., Huynh, Frank K., Green, Michelle F., Anderson, Kristin A., Wagner, Gregory R.   +4 more
core   +3 more sources

Sirtuins in kidney diseases: potential mechanism and therapeutic targets

Cell Communication and Signaling
Sirtuins, which are NAD+-dependent class III histone deacetylases, are involved in various biological processes, including DNA damage repair, immune inflammation, oxidative stress, mitochondrial homeostasis, autophagy, and apoptosis.
Qi Jin, Fang Ma, Tongtong Liu, Liping Yang, Huimin Mao, Yuyang Wang, Liang Peng, Ping Li, Yongli Zhan   +8 more
doaj   +2 more sources