Results 41 to 50 of about 22,350 (290)
Frontiers in Cardiovascular Medicine, 2022 Vascular calcification (VC) is a common pathological change in many chronic diseases, such as diabetes and chronic kidney disease. It is mainly deposited in the intima and media of vessels in the form of hydroxyapatite.
Shuangshuang Wang, Siwang Hu
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Sirtuin Modulators in Cellular and Animal Models of Human Diseases
Frontiers in Pharmacology, 2021 Sirtuins use NAD+ to remove various acyl groups from protein lysine residues. Through working on different substrate proteins, they display many biological functions, including regulation of cell proliferation, genome stability, metabolism, and cell ...
Jun Young Hong, Hening Lin, Hening Lin
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Effect of breed on the expression of Sirtuins (Sirt1-7) and antioxidant capacity in porcine brain
Animal, 2013 Sirtuins, NAD-dependent histone deacetylase (HDAC), are correlated to aging and antioxidant. The aim of this study was to determine breed differences of porcine Sirtuins expression and antioxidant capacity in brain between Jinhua pigs (a fatty breed of ...
Y. Ren +5 more
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Oncometabolic role of mitochondrial sirtuins in glioma patients.
PLoS ONE, 2023 Mitochondrial sirtuins have diverse role specifically in aging, metabolism and cancer. In cancer, these sirtuins play dichotomous role as tumor suppressor and promoter.
Maria Fazal Ul Haq +7 more
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Extranuclear sirtuins and metabolic stress [PDF]
, 2018 Significance: Extranuclear sirtuins in cytosol (SIRT2) and mitochondria (SIRT3, SIRT4, and SIRT5) are key regulators of metabolic enzymes and the antioxidative defense mechanisms.
Elkhwanky, M. S. (Mahmoud S.) +1 more
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Sirtuins and Their Relevance to the Kidney [PDF]
Journal of the American Society of Nephrology, 2010 Sirtuins (silent information regulator 2 [Sir2] proteins) belong to an ancient family of evolutionary conserved nicotinamide adenine dinucleotide (NAD)(+)-dependent enzymes with deacetylase and/or mono-ADP-ribosyltransferase activity. They regulate DNA repair and recombination, chromosomal stability, and gene transcription, and most importantly mediate
Chuan-Ming, Hao, Volker H, Haase
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Frontiers in Neuroscience, 2020 Neurodegeneration of the central and enteric nervous systems is a common feature of aging and aging-related diseases, and is accelerated in individuals with metabolic dysfunction including obesity and diabetes.
Pavithra Chandramowlishwaran +9 more
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Interaction of Klotho and sirtuins
Experimental Gerontology, 2023 In this article, we review the articles that have reported the interaction between Klotho and sirtuins.Sirtuins are a family of histone deacetylase enzymes that are considered to be the main regulators of biological processes. This family is one of the essential factors for postponing aging and increasing the life span of organisms.
Farzaneh Rostamzadeh +2 more
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Sirtuins at the Service of Healthy Longevity
Frontiers in Physiology, 2021 Sirtuins may counteract at least six hallmarks of organismal aging: neurodegeneration, chronic but ineffective inflammatory response, metabolic syndrome, DNA damage, genome instability, and cancer incidence.
Mateusz Watroba, Dariusz Szukiewicz
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Sirtuins: New Roles for Sirtuins in Aging and Disease [PDF]
Innovation in Aging, 2020 Abstract Sirtuins are NAD+-dependent enzymes related to yeast silent information regulator-2, a histone deacetylase that prevents premature aging through chromatin silencing. Mammalian sirtuins, SIRT1-SIRT7, have key functions that protect against diverse aging-related pathologic states, from cancer to metabolic and neurodegenerative ...
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