Results 41 to 50 of about 30,210 (302)
Regulation of sirtuin function by posttranslational modifications
Frontiers in Pharmacology, 2012 Sirtuins are homologs of the yeast silencing information regulator 2 (Sir2) protein, an NAD+-dependent (histone) deacetylase. In mammals 7 different sirtuins, SIRT1-7, have been identified, which share a common catalytic core domain but possess distinct ...
Franziska eFlick, Bernhard eLüscher
doaj +1 more source
Frontiers in Oncology, 2020 Sirtuins, class III histone deacetylases, are involved in multiple biological processes in cancer initiation and progression. However, the diverse expression patterns and prognostic values of sirtuins in cancers have yet to be elucidated.
Ying Tan +4 more
doaj +1 more source
RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer [PDF]
, 2018 Purpose: Alteration in cell death is a hallmark of cancer. A functional role regulating survival, apoptosis, and necroptosis has been attributed to RIP1/3 complexes.Experimental Design: We have investigated the role of RIP1 and the effects of MC2494 in ...
A. Baldi +23 more
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Hepatology, EarlyView., 2022 NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger +7 more
wiley +1 more source
Sirtuins—The New Important Players in Women’s Gynecological Health
Antioxidants, 2021 The participation of sirtuins in the regulation of oxidative stress and inflammation lies at the basis of their possible modes of action and is related to their expression in various cell structures; their location in the mitochondria and blood plasma ...
Ewa Maria Kratz +3 more
doaj +1 more source
Segmental aging underlies the development of a Parkinson phenotype in the AS/AGU rat [PDF]
, 2016 There is a paucity of information on the molecular biology of aging processes in the brain. We have used biomarkers of aging (SA β-Gal, p16Ink4a, Sirt5, Sirt6, and Sirt7) to demonstrate the presence of an accelerated aging phenotype across different ...
Khojah, Sohair M. +3 more
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Frontiers in Cardiovascular Medicine, 2022 Vascular calcification (VC) is a common pathological change in many chronic diseases, such as diabetes and chronic kidney disease. It is mainly deposited in the intima and media of vessels in the form of hydroxyapatite.
Shuangshuang Wang, Siwang Hu
doaj +1 more source
Emerging roles of telomeric chromatin alterations in cancer [PDF]
, 2019 Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria +2 more
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The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular Diseases
Journal of Cardiovascular Development and Disease, 2023 Sirtuins belong to the class III histone deacetylases and possess nicotinamide adenine dinucleotide-dependent deacetylase activity. They are involved in the regulation of multiple signaling pathways implicated in cardiovascular diseases.
Yuqin Wang +5 more
doaj +1 more source
One special question to start with: can HIF/NFkB be a target in inflammation? [PDF]
, 2015 Hypoxia and Inflammation are strictly interconnected with important consequences at clinical and therapeutic level. While cell and tissue damage due to acute hypoxia mostly leads to cell necrosis, in chronic hypoxia, cells that are located closer to ...
CARNEVALE, ILARIA +8 more
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