Results 11 to 20 of about 17,907 (258)
Sirtuins, Metabolism and Cancer [PDF]
Frontiers in Pharmacology, 2012 More than a decade ago, sirtuins were discovered as a highly conserved family of NAD+-dependent enzymes that extend lifespan in lower organisms. In mammals, sirtuins are key regulators of stress responses and metabolism, influencing a range of diseases ...
Barbara eMartinez-Pastor +1 more
doaj +5 more sources
Sirtuins and Insulin Resistance [PDF]
Frontiers in Endocrinology, 2018 The mammalian Sirtuins (SIRT1-7) are an evolutionarily conserved family of NAD+-dependent deacylase and mono-ADP-ribosyltransferase. Sirtuins display distinct subcellular localizations and functions and are involved in cell survival, senescence ...
Shuang Zhou +2 more
doaj +3 more sources
Sirtuins, Bioageing, and Cancer [PDF]
Journal of Aging Research, 2011 The Sirtuins are a family of orthologues of yeast Sir2 found in a wide range of organisms from bacteria to man. They display a high degree of conservation between species, in both sequence and function, indicative of their key biochemical roles. Sirtuins
D. McGuinness +3 more
doaj +4 more sources
Mitochondrial Sirtuins in Reproduction [PDF]
Antioxidants, 2021 Mitochondria act as hubs of numerous metabolic pathways. Mitochondrial dysfunctions contribute to altering the redox balance and predispose to aging and metabolic alterations. The sirtuin family is composed of seven members and three of them, SIRT3-5, are housed in mitochondria.
Di Emidio, Giovanna +5 more
openaire +5 more sources
Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors [PDF]
International Journal of Molecular Sciences, 2021 Sirtuins (SIRTs) are NAD+-dependent deacetylases that regulate proliferation and cell death. In the human ovary, granulosa cells express sirtuin 1 (SIRT1), which has also been detected in human tumors derived from granulosa cells, i.e., granulosa cell tumors (GCTs), and in KGN cells.
Nina Schmid +7 more
openaire +2 more sources
Sirtuins and cognition: implications for learning and memory in neurological disorders
Frontiers in Physiology, 2022 Sirtuins are an evolutionarily conserved family of regulatory proteins that function in an NAD+ -dependent manner. The mammalian family of sirtuins is composed of seven histone deacetylase and ADP-ribosyltransferase proteins (SIRT1-SIRT7) that are found ...
Eric Fagerli +5 more
doaj +1 more source
Sirtuins as a potential molecular target of cosmetic ingredients [PDF]
Farmacja Polska, 2022 Sirtuins are a group of enzymes belonging to histone deacetylases. However, they can also catalyze other deacylation reactions (including, for example, demallonylation, desuccinylation or deglutarylation), as well as ADP-ribosylation reactions.
Katarzyna Brezdeń +2 more
doaj +1 more source
, 2011 Members of the sirtuin family including the founding protein Sir2 in Saccharomyces cerevisiae have been linked to lifespan extension in simple organisms. This finding prompted evaluation of the role of Sir2 orthologues in many aging-associated conditions including neurodegeneration, type II diabetes and cancer.
Sumit S, Mahajan +3 more
openaire +2 more sources
Respiratory Research, 2022 Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacylases and deacetylases that participate in a variety of cellular processes, including transcriptional activity, energy metabolism, DNA damage response, inflammation, apoptosis ...
Yahui Liu, Guochao Shi
doaj +1 more source
Alterations of sirtuins in mitochondrial cytochrome c-oxidase deficiency. [PDF]
PLoS ONE, 2017 Sirtuins are NAD+ dependent deacetylases, which regulate mitochondrial energy metabolism as well as cellular response to stress. The NAD/NADH-system plays a crucial role in oxidative phosphorylation linking sirtuins and the mitochondrial respiratory ...
Arne Björn Potthast +3 more
doaj +1 more source