Towards Simplification of Ketogenic Diet in Epilepsy: Effect of Caprylic (C8) and Capric (C10) Acid on the Mitochondrial Respiratory Chain in Murine Hippocampal Neurons In Vitro. [PDF]
NutrientsRühling MR, Hartmann H, Das AM.
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Risk of Incident Colorectal Carcinoma in Patients With Type 2 Diabetes on SGLT‐2 Inhibitor Users
Pharmacoepidemiology and Drug Safety, Volume 35, Issue 3, March 2026.ABSTRACT Background The role of sodium‐glucose co‐transporter‐2 inhibitor (SGLT2I) in colorectal carcinoma (CRC) risk in patients with type 2 diabetes mellitus (T2D) remains controversial. This study aimed to examine the association between SGLT2I use and the risk of incident CRC in patients with T2D.
Tsung‐Kun Lin +6 more
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Placental Expression of Sirtuins in Women with Gestational Diabetes. [PDF]
Genes (Basel)Czerewaty M +7 more
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Phytotherapy Research, Volume 40, Issue 3, Page 965-985, March 2026.Lithospermic acid (LA) inactivates the p53 signaling pathway via directly targeting SIRT3, thereby alleviating oxidative stress and abnormal apoptosis in the progression of doxorubicin (Dox)‐induced cardiomyocytes. ABSTRACT Doxorubicin (Dox)‐induced cardiomyopathy (DIC) is characterized by significant myocardial damage that can progress to dilated ...
Yining Zhao +13 more
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DNA Damage-induced Post-transcriptional Regulation of SIRT4 by the miR-15/16 Family Modulates Chemosensitivity in Cancer Cells. [PDF]
Cancer Genomics ProteomicsWon S, Ko M, Jeong SM.
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Aging Triggers an Intestinal Energy Crisis and HDL3 Deficiency Disrupting Gut–Liver Axis Homeostasis
Aging Cell, Volume 25, Issue 3, March 2026.The age‐related mitochondrial energy crisis and the consequent disruption of intestinal HDL3 biosynthesis converge to disrupt the gut–liver HDL3‐LPS/TLR4 axis, compromising hepatic anti‐inflammatory function and driving liver injury, an effect reversible upon NMN administration.
Yumeng Li +7 more
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A Double-Edged Role for SIRT7 in Cancer: Can Anti-Cancer Immunity Tip the Balance? [PDF]
Pharmaceuticals (Basel)Tarighi S +5 more
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Nicotinamide (Vitamin B3) Deficiency in Follicular Fluid of Patients With Ovarian Ageing
Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.ABSTRACT Nicotinamide is an essential precursor of NAD involved in energy metabolism. A decline in NAD levels across tissues during ageing is well‐documented, and NAD metabolism has been implicated in ovarian ageing. We investigated the relationship between ovarian ageing and the levels of nicotinamide (NAM) and its metabolite 1‐methylnicotinamide (MNA)
Cinzia Bocca +5 more
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Diet-Induced Browning of White Adipose Tissue: Molecular Targets, Mechanisms, and Therapeutic Potential. [PDF]
Curr Issues Mol BiolYang ZD +5 more
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The Journal of Physiology, Volume 604, Issue 6, Page 2458-2472, 15 March 2026.Abstract figure legend A schematic diagram outlining the concept of enviromimetics, and the subclasses of exercise mimetics, epimimetics and cognitomimetics. The rationale is that environmental stimulation and lifestyle factors, including physical activity and cognitive stimulation, have shown beneficial effects across a range of human conditions ...
Anthony J. Hannan
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