Results 201 to 210 of about 354,238 (282)

Automatically Defining Protein Words for Diverse Functional Predictions Based on Attention Analysis of a Protein Language Model

Advanced Science, EarlyView.
Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen, Jingrui Zhong, Xiaochun Zhang, Jingke Chen, Lin Guo, Xiaoliang Xiong, Xiaonan Zhang, Xiangyu Liu, Bailong Xiao, Boxue Tian   +9 more
wiley   +1 more source

Efficient cloning of linear DNA inserts (ECOLI) into plasmids using site-directed mutagenesis. [PDF]

Sci Rep
Paclikova P, Harnos J.
europepmc   +1 more source

Optimization of Antibacterial Activity in Tibetan Swine α-Helix Peptide TP by Site-Directed Mutagenesis. [PDF]

Front Microbiol, 2022
Li G, Yuan X, Chen H, Li B, Shao C, Zhu Y, Lai Z, Shan A.   +7 more
europepmc   +1 more source

Site-Directed Mutagenesis

International Journal of Research Studies in Biosciences, 2017
openaire   +1 more source

Site-Directed Mutagenesis v1

This protocols describes the procedure for site-directed mutagenesis by PCR
openaire   +1 more source

Combining Electrochemical Reduction with Biosynthesis for Directed Conversion of CO2 into a Library of C3 Chemicals

Advanced Science, EarlyView.
In the H‐type electrolytic cell, carbon dioxide is reduced to acetic acid via electro‐microbial catalysis. The simply processed acetic acid is further converted through biological fermentation into high‐value‐added products, including acrylic acid, L‐lactic acid, and β‐alanine.
Kaixing Xiao, Shanquan Liang, Xujun Zhao, Zhiyao Peng, Ruoshi Luo, Jikai Zong, Ling Zhou, Yude Su, Dan Wang   +8 more
wiley   +1 more source

Correction: Pandey et al. Enhancing the Conformational Stability of the cl-Par-4 Tumor Suppressor via Site-Directed Mutagenesis. <i>Biomolecules</i> 2023, <i>13</i>, 667. [PDF]

Biomolecules
Pandey S, Raut KK, Baudin A, Djemri L, Libich DS, Ponniah K, Pascal SM.   +6 more
europepmc   +1 more source

Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists. [PDF]

Acta Pharmacol Sin, 2023
Darbalaei S, Chang RL, Zhou QT, Chen Y, Dai AT, Wang MW, Yang DH.   +6 more
europepmc   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Biocatalytic Regioselective C‐Formylation of Resorcinol Derivatives

Angewandte Chemie, EarlyView.
An acyltransferase from Chromobacterium sphagni (CsATase) was identified that catalyzes the regioselective formylation of resorcinol substrates. The formylation of substituted resorcinol derivatives yielded mono‐formylated products with up to 99% conversion and up to 74% isolated yield.
Lilla Gal, Suresh Rohan, Anna Żądło‐Dobrowolska, Bianca Hilweg, Judith Müller, Kai Tittmann, Wolfgang Kroutil   +6 more
wiley   +2 more sources