Results 21 to 30 of about 3,871 (235)
Microtremor Recording Surveys to Study the Effects of Seasonally Frozen Soil on Site Response
Sensors, 2023 Microtremor recording tests using an accelerometer were carried out in this paper with the aim of characterizing the effects of seasonally frozen soil on the seismic site response, including the two-direction microtremor spectrum, site predominant ...
Shengyang Chen, Jie Lei, Ya Li
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Viruses, 2022 Due to the emergence of new variants of the SARS-CoV-2 coronavirus, the question of how the viral genomes evolved, leading to the formation of highly infectious strains, becomes particularly important. Three major emergent strains, Alpha, Beta and Delta,
Monika Klara Kurpas +3 more
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Signatures of neutral evolution in exponentially growing tumors: A theoretical perspective.
PLoS Computational Biology, 2021 Recent work of Sottoriva, Graham, and collaborators have led to the controversial claim that exponentially growing tumors have a site frequency spectrum that follows the 1/f law consistent with neutral evolution. This conclusion has been criticized based
Hwai-Ray Tung, Rick Durrett
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Directional Selection and the Site-Frequency Spectrum [PDF]
Genetics, 2001 Abstract In this article we explore statistical properties of the maximum-likelihood estimates (MLEs) of the selection and mutation parameters in a Poisson random field population genetics model of directional selection at DNA sites. We derive the asymptotic variances and covariance of the MLEs and explore the power of the likelihood ...
C D, Bustamante +3 more
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The neutral frequency spectrum of linked sites [PDF]
Theoretical Population Biology, 2017 Abstract We introduce the conditional Site Frequency Spectrum (SFS) for a genomic region linked to a focal mutation of known frequency. An exact expression for its expected value is provided for the neutral model without recombination. Its relation with the expected SFS for two sites, 2-SFS, is discussed.
Ferretti, Luca +5 more
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Controlling for Variable Transposition Rate with an Age-Adjusted Site Frequency Spectrum [PDF]
Genome Biology and Evolution, 2021 Abstract Recognition of the important role of transposable elements (TEs) in eukaryotic genomes quickly led to a burgeoning literature modeling and estimating the effects of selection on TEs. Much of the empirical work on selection has focused on analyzing the site frequency spectrum (SFS) of TEs.
Robert Horvath +3 more
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Site Frequency Spectrum of the Bolthausen-Sznitman Coalescent [PDF]
Latin American Journal of Probability and Mathematical Statistics, 2019 Abstract We derive explicit formulas for the two first moments of he site frequency spectrum ( SFS n,b ) 1≤ b ≤ n
Götz Kersting +2 more
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Learning Natural Selection from the Site Frequency Spectrum [PDF]
Genetics, 2013 Abstract Genetic adaptation to external stimuli occurs through the combined action of mutation and selection. A central problem in genetics is to identify loci responsive to specific selective constraints. Many tests have been proposed to identify the genomic signatures of natural selection by quantifying the skew in the site frequency ...
Ronen, Roy +3 more
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Expectation of the Site Frequency Spectrum
, 2021 The site frequency spectrum describes variation among a set of n DNA sequences. Its i'th entry (i=1,2,...,n-1) is the number of nucleotide sites at which the mutant allele is present in i copies. Under selective neutrality, random mating, and constant population size, the expected value of the spectrum is well known but somewhat puzzling.
Rogers, Alan R., Wooding, Stephen P.
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