Results 51 to 60 of about 450,494 (340)
Skeletal Muscle, 2019 Background Niemann-Pick disease type A (NPDA), a disease caused by mutations in acid sphingomyelinase (ASM), involves severe neurodegeneration and early death.
V. Michailowsky +9 more
doaj +1 more source
Handling rescue therapy in myasthenia gravis clinical trials: why it matters and why you should care
Annals of Clinical and Translational Neurology, EarlyView.Abstract Myasthenia gravis (MG) clinical trials typically allow rescue therapy during follow‐up in the event of marked worsening of MG symptoms. Failure to appropriately address rescue therapy in defining treatment effects and planning statistical analyses may yield biased estimates, increase false positive rates, or decrease statistical power – all of
Justin M. Leach +3 more
wiley +1 more source
A three-dimensional model of skeletal muscle tissues [PDF]
arXiv, 2022 Skeletal muscles are living tissues that can undergo large deformations in short periods of time and that can be activated to produce force. In this paper we use the principles of continuum mechanics to propose a dynamic, fully non-linear, and three-dimensional model to describe the deformation of these tissues.
arxiv
Muscle contraction and the elasticity-mediated crosstalk effect [PDF]
Phys. Rev. E 87, 052714 (2013), 2013 Cooperative action of molecular motors is essential for many cellular processes. One possible regulator of motor coordination is the elasticity-mediated crosstalk (EMC) coupling between myosin II motors whose origin is the tensile stress that they collectively generate in actin filaments.
arxiv +1 more source
Muscle Gene Sets: a versatile methodological aid to functional genomics in the neuromuscular field
Skeletal Muscle, 2019 Background The approach of building large collections of gene sets and then systematically testing hypotheses across these collections is a powerful tool in functional genomics, both in the pathway analysis of omics data and to uncover the polygenic ...
Apostolos Malatras +2 more
doaj +1 more source
Metabolomic signatures for the longitudinal reduction of muscle strength over 10 years
Skeletal Muscle, 2022 Background Skeletal muscles are essential components of the neuromuscular skeletal system that have an integral role in the structure and function of the synovial joints which are often affected by osteoarthritis (OA).
Salem Werdyani +7 more
doaj +1 more source
UDP‐glucose dehydrogenase variants cause dystroglycanopathy
Annals of Clinical and Translational Neurology, EarlyView.Abstract UDP‐glucose dehydrogenase (UGDH) variants have been associated with hypotonia, developmental delay, and epilepsy. We report the first pathologic evidence of dystroglycanopathy in siblings with UGDH variants. Both presented around 6 months with developmental delay and elevated creatinine kinase.
Anna M. Reelfs +8 more
wiley +1 more source
Mitochondrial Ca2+ uptake in skeletal muscle health and disease [PDF]
, 2016 Muscle uses Ca2+ as a messenger to control contraction and relies on ATP to maintain the intracellular Ca2+ homeostasis. Mitochondria are the major sub-cellular organelle of ATP production. With a negative inner membrane potential, mitochondria take up Ca2+ from their surroundings, a process called mitochondrial Ca2+ uptake.
arxiv +1 more source
Activation of a muscle as a mapping of stress-strain curves [PDF]
Extreme Mechanics Letters 28 (2019): 37-42, 2019 The mathematical modeling of the contraction of a muscle is a crucial problem in biomechanics. Several different models of muscle activation exist in literature. A possible approach to contractility is the so-called active strain: it is based on a multiplicative decomposition of the deformation gradient into an active contribution, accounting for the ...
arxiv +1 more source
Skeletal Muscle, 2021 Striated muscle is a highly plastic and regenerative organ that regulates body movement, temperature, and metabolism—all the functions needed for an individual’s health and well-being.
Osvaldo Contreras +2 more
doaj +1 more source