Results 161 to 170 of about 68,097 (255)

Correlation Between Gut Microbiota, Metabolites, and Diabetic Complications: A Two‐Sample Mendelian Randomization Study

Medicine Advances, EarlyView.
Fang et al. demonstrate a significant causal relationship among gut microbiota, gut metabolites, and diabetic complications, highlighting a biological link underlying mechanisms of diabetic vascular diseases. These findings provide important implications for future therapeutic strategy and risk prediction.
Jiaxi Fang, Leilei Zhai, Chan Huang, Liqin Li, Yong Wang, Jiaojiao Fan, Wei Zhou   +6 more
wiley   +1 more source

Epigenetic inhibition of class I histone deacetylases by MS-275 attenuates diabetic skeletal muscle atrophy via Akt/ARK5-FoxO and myostatin-Smad signaling. [PDF]

Front Endocrinol (Lausanne)
Son Y, Byeon HE, Choi SE, Kim Y, Heo YJ, Kwon SB, Choi J, Han SJ, Jeon J, Kim HJ, Lee N, Lee KW.   +11 more
europepmc   +1 more source

With Regard to the Expression Status of Sarcolemmal Aquaporin 4 in Human Muscular Dystrophies

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT Human muscular dystrophies are inherited muscle‐wasting diseases caused by the various kinds of gene mutations. Among them, Duchenne muscular dystrophy (DMD) is a representative type. Before the discovery of the causative dystrophin gene of DMD, the fragile myofiber plasma membrane was thought to be the trigger of myofiber necrosis in DMD ...
Yoshihiro Wakayama, Takahiro Jimi
wiley   +1 more source

Cisplatin-Induced Skeletal Muscle Atrophy: Biomolecular Mechanisms and the Protective Role of Exercise-Induced Myokines. [PDF]

Biomolecules
Xu M, Liu X.
europepmc   +1 more source

Exercise, exerkines, and muscle–brain crosstalk in Parkinson's disease

Neuroprotection, EarlyView.
Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with motor and non‐motor symptoms, driven by dopaminergic loss and α‐synuclein accumulation. Beyond neurodegeneration, growing evidence highlights skeletal muscle health as a key determinant of prognosis, with sarcopenia and frailty contributing to greater disability, fall ...
Salomón Páez‐García, Edgar Alvarado, Alejandro Cuevas, Laura Valverde, Eduardo Salinas, Kevin O'Hara‐Veintimilla, María Cruz Rodríguez‐Oroz, Miguel Germán Borda   +7 more
wiley   +1 more source

Imaging patterns and genetic associations of brain atrophy across distinct symptom stages in Parkinson's disease

Neuroprotection, EarlyView.
Early disease stages showed limited cortical atrophy and enrichment of synaptic and calcium signaling pathways, whereas advanced stages demonstrated widespread cortical degeneration associated with immune activation and extracellular matrix remodeling.
Yi Ji, Liujia Lu, Kaidong Chen, Ruixuan Zhang, Yao Lu, Yachen Shi, Xiangming Fang   +6 more
wiley   +1 more source

Vitamin D binding protein induces skeletal muscle atrophy and contributes to cancer-associated muscle wasting independently of vitamin D status in preclinical models. [PDF]

Nat Commun
Raiteri T, Reano S, Scircoli A, Zaggia I, Antonioli A, Faletti S, Favero F, Manfredi M, Pelicci G, Corà D, Scotti L, Kew RR, Prodam F, Porporato PE, Filigheddu N.   +14 more
europepmc   +1 more source

Dietary Protein Reduction During Isocaloric Conditions Reduces Body Weight in Men With Overweight or Obesity

Obesity, EarlyView.
Protein restriction, while meeting minimum requirements, induced weight loss and increased FGF21 in men with obesity under isocaloric conditions, without caloric restriction. ABSTRACT Objective Dietary protein reduction increases plasma fibroblast growth factor 21 (FGF21) and energy requirements in lean men under eucaloric conditions.
Aslak E. Lyster, Amalie S. Frederiksen, Jacob K. Jensen, Annemarie Lundsgaard, Nicoline R. Andersen, Kasper S. Jørgensen, Daniela Weber, Lukas Nachtigall, Erik A. Richter, Andreas M. Fritzen, Bente Kiens   +10 more
wiley   +1 more source

Decorin Deficiency Promotes D-Galactose-Induced Skeletal Muscle Atrophy and Fibrosis by Regulating ITGB1/Akt/mTOR Signalling Pathway. [PDF]

J Cachexia Sarcopenia Muscle
Luo X, Zhang M, Chen L, Wang R, Lian J, Yang Z, Iozzo RV, Wang J, Zhang Y, Bi X.   +9 more
europepmc   +1 more source

The magnitude and economic replacement value of wild meat obtained from ‘recreational’ big game hunting in the United States

People and Nature, EarlyView.
Abstract Meat production has notable benefits for food security, nutrition and various production economies, but has elicited substantial negative environmental impacts. Recreational hunting provides an alternative to agricultural meat production for over 24 million hunters worldwide.
Shane P. Mahoney, Richard D. Honor
wiley   +1 more source