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SnapShot: Skeletal muscle atrophy
Cell, 2022Skeletal muscle size is highly plastic and sensitive to a variety of stimuli. Muscle atrophy occurs as the result of changes in multiple signaling pathways that regulate both protein synthesis and degradation. The signaling pathways that are activated or inhibited depend on the specific stimuli that are altered.
Leslie M, Baehr +3 more
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Mechanisms of skeletal muscle atrophy
Current Opinion in Rheumatology, 2006Recent clinical and mechanistic studies have shown that increased proteolysis is a major determinant of muscle wasting in numerous catabolic states and of alterations in myopathies or dystrophies. The implications of these observations for improving muscle mass and function are discussed.Several proteolytic systems (i.e. the ubiquitin-proteasome system,
Ventadour, Sophie, Attaix, Didier
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The molecular basis of skeletal muscle atrophy
American Journal of Physiology-Cell Physiology, 2004Skeletal muscle atrophy attributable to muscular inactivity has significant adverse functional consequences. While the initiating physiological event leading to atrophy seems to be the loss of muscle tension and a good deal of the physiology of muscle atrophy has been characterized, little is known about the triggers or the molecular signaling events ...
Robert W, Jackman, Susan C, Kandarian
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Lysosomes and disuse atrophy of skeletal muscle
Archives of Biochemistry and Biophysics, 1971The specific activities of the acid hydrolases β-glucosidase, β-galactosidase, β-N-acetylhexosaminidase, arylsulfatase, and acid phosphatase have been measured during the time course of disuse atrophy of rat gastrocnemius muscles. These enzymes are considered to be lysosomal in origin.
S R, Max, R F, Mayer, L, Vogelsang
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Disuse Atrophy of Human Skeletal Muscles
Archives of Neurology, 1969DISUSE ATROPHY is a term frequently and glibly used by clinicians and pathologists alike when faced with a nonspecific muscular atrophy. Unfortunately for both, this is usually a diagnosis of exclusion. Histological changes in cases of pure disuse atrophy in human skeletal muscles are wanting.
A N, Patel, Z A, Razzak, D K, Dastur
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Role of ATF4 in skeletal muscle atrophy
Current Opinion in Clinical Nutrition & Metabolic Care, 2017Here, we discuss recent work focused on the role of activating transcription factor 4 (ATF4) in skeletal muscle atrophy.Muscle atrophy involves and requires widespread changes in skeletal muscle gene expression; however, the transcriptional regulatory proteins responsible for those changes are not yet well defined. Recent work indicates that some forms
Christopher M, Adams +2 more
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Glucocorticoid-induced skeletal muscle atrophy
The International Journal of Biochemistry & Cell Biology, 2013Many pathological states characterized by muscle atrophy (e.g., sepsis, cachexia, starvation, metabolic acidosis and severe insulinopenia) are associated with an increase in circulating glucocorticoids (GC) levels, suggesting that GC could trigger the muscle atrophy observed in these conditions. GC-induced muscle atrophy is characterized by fast-twitch,
O, Schakman +4 more
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Skeletal Muscle Atrophy in Bioengineered Skeletal Muscle: A New Model System
Tissue Engineering Part A, 2013Skeletal muscle atrophy has been well characterized in various animal models, and while certain pathways that lead to disuse atrophy and its associated functional deficits have been well studied, available drugs to counteract these deficiencies are limited.
Peter H U, Lee, Herman H, Vandenburgh
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JAMA: The Journal of the American Medical Association, 1942
Mammalian skeletal muscle is served by a number of different types of nerve fibers. Some represent the central and others the autonomic nervous system. Diagrammatic representation of the component parts of skeletal muscle innervation has been attempted in figure 1.
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Mammalian skeletal muscle is served by a number of different types of nerve fibers. Some represent the central and others the autonomic nervous system. Diagrammatic representation of the component parts of skeletal muscle innervation has been attempted in figure 1.
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