Results 171 to 180 of about 1,143,192 (208)
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Atrophy of Skeletal Muscle in Patients With Cushing's Syndrome
Archives of Neurology, 1970CUSHING'S syndrome or therapy with any of the glucocorticoids may cause proximal muscular weakness.1,2Muscle wasting is usually apparent clinically. Occasional fibers undergoing degeneration and scattered atrophic fibers have been described in muscle biopsy specimens.1,3,4In this paper, histochemical studies of affected muscle in two patients with ...
D E, Pleasure, G O, Walsh, W K, Engel
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2017
Skeletal muscle atrophy occurs when there is a higher concentration of the transcription factor Forkhead box protein O1 (Foxo-1) inside the nucleus of a skeletal muscle cell than in the cytoplasm. Within a skeletal muscle cell, only dephosphorylated Foxo-1 can enter the nucleus, while only phosphorylated Foxo-1 can exit the nucleus.
Furman, Samantha +2 more
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Skeletal muscle atrophy occurs when there is a higher concentration of the transcription factor Forkhead box protein O1 (Foxo-1) inside the nucleus of a skeletal muscle cell than in the cytoplasm. Within a skeletal muscle cell, only dephosphorylated Foxo-1 can enter the nucleus, while only phosphorylated Foxo-1 can exit the nucleus.
Furman, Samantha +2 more
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Oxidative stress in skeletal muscle atrophied by immobiIization
Acta Physiologica Scandinavica, 1991The production of free radicals in the mitochondria has been investigated more than that in other organelles, and is believed to play a major role in oxidative stress in the cell. In the muscle, the increase in muscular activity enhances the oxygen consumption and increased oxygen consumption accelerates the production of free radicals in the ...
H, Kondo, M, Miura, Y, Itokawa
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Effect of ketoleucine treatment on atrophy of skeletal muscle
Experimental Neurology, 1988There is a net loss of skeletal muscle protein in muscle-wasting disorders including the muscular dystrophies and denervation atrophy. Regardless of the nature of the underlying defect, a treatment that could reduce the rate of muscle protein degradation may be of therapeutic value in these conditions.
W C, Yee +3 more
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Progressive Atrophy of Skeletal Muscles
Postgraduate Medicine, 1967The “motor unit” concept is delineated and a classification of atrophies is presented. The four main categories are composed of disease states associated with (1) proximal symmetric, (2) distal symmetric, (3) diffuse bilateral and (4) restricted atrophies of skeletal muscles.
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Effect of Succinylcholine on Skeletal Muscle with Immobilization Atrophy
Anesthesiology, 1974The effects of succinylcholine (SCh) on both normal and immobilized canine gastroenemius muscle were compared and contrasted with respect to potassium (K+) flux, VO2, and muscle tension. Muscle K+ efflux and VO2, increased more in immobilized atrophie than in normal muscle. Neither normal nor immobilized muscle showed increased tension with SCh.
G A, Gronert, R A, Theye
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A Study of Disuse Atrophy of Skeletal Muscle in the Rabbit
The Journal of Bone & Joint Surgery, 19571. There is a fundamental difference in the reaction to immobilization of the tibialis anterior and the gastroenemius its the rabbit. 2. There is an increased blood flow in both atrophy and hypertrophy of skeletal muscle in this animal. 3. Atrophy and hypertrophy appear to represent a change in intracellular cotsstituents without change in the water ...
A B, FERGUSON, L, VAUGHAN, L, WARD
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Oxidative Metabolism of Skeletal Muscle in Steroid Atrophy
Archives of Neurology, 1974Corticosteroids cause severe atrophy of skeletal muscle. We have assessed the oxidative capacity of rat skeletal muscles following prolonged steroid administration. Dexamethasone caused severe atrophy and loss of oxidative capacity. Hydrocortisone also caused severe atrophy and loss of oxidative capacity, but to a lesser extent.
C L, Koski, D H, Rifenberick, S R, Max
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Regrowth of Skeletal Muscle Atrophied from Inactivity
Medicine & Science in Sports & Exercise, 2004The current state of knowledge regarding regrowth of skeletal muscle after inactivity-induced atrophy is reviewed. Muscle regrowth is incomplete after hindlimb suspension in juvenile rats and after limb immobilization in old animals. The process of regrowth from immobilization-induced atrophy likely involves the reversal of directional changes in ...
Shuichi, Machida, Frank W, Booth
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Skeletal muscle hypertrophy and atrophy signaling pathways
The International Journal of Biochemistry & Cell Biology, 2005Skeletal muscle hypertrophy is defined as an increase in muscle mass, which in the adult animal comes as a result of an increase in the size, as opposed to the number, of pre-existing skeletal muscle fibers. The protein growth factor insulin-like growth factor 1 (IGF-1) has been demonstrated to be sufficient to induce skeletal muscle hypertrophy.
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