Results 31 to 40 of about 64,656 (260)

Smad4 restricts differentiation to promote expansion of satellite cell derived progenitors during skeletal muscle regeneration

eLife, 2016
Skeletal muscle regenerative potential declines with age, in part due to deficiencies in resident stem cells (satellite cells, SCs) and derived myogenic progenitors (MPs); however, the factors responsible for this decline remain obscure. TGFβ superfamily
Nicole D Paris, Andrew Soroka, Alanna Klose, Wenxuan Liu, Joe V Chakkalakal   +4 more
doaj   +1 more source

Mitochondrial glycerol 3‐phosphate dehydrogenase promotes skeletal muscle regeneration

EMBO Molecular Medicine, 2018
While adult mammalian skeletal muscle is stable due to its post‐mitotic nature, muscle regeneration is still essential throughout life for maintaining functional fitness.
Xiufei Liu, Hua Qu, Yi Zheng, Qian Liao, Linlin Zhang, Xiaoyu Liao, Xin Xiong, Yuren Wang, Rui Zhang, Hui Wang, Qiang Tong, Zhenqi Liu, Hui Dong, Gangyi Yang, Zhiming Zhu, Jing Xu, Hongting Zheng   +16 more
doaj   +1 more source

Skeletal muscle regeneration in cancer cachexia [PDF]

Clinical and Experimental Pharmacology and Physiology, 2016
SummaryMuscle wasting is the most important phenotypic and clinical feature of cancer cachexia, and the principal cause of impaired physical function, fatigue, and respiratory complications. Muscle loss has been attributed to a variable combination of reduced nutritional intake and an imbalance between anabolic and catabolic processes.
Bossola, M, Marzetti, E, Rosa, F, Pacelli, F   +3 more
openaire   +3 more sources

KLF4 regulates skeletal muscle development and regeneration by directly targeting P57 and Myomixer

Cell Death and Disease, 2023
Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell proliferation, apoptosis, and differentiation.
Shufang Cai, Xiaoyu Wang, Rong Xu, Ziyun Liang, Qi Zhu, Meilin Chen, Zhuhu Lin, Chenggan Li, Tianqi Duo, Xian Tong, Enru Li, Zuyong He, Xiaohong Liu, Yaosheng Chen, Delin Mo   +14 more
doaj   +1 more source

Biomimetic Scaffolds for Skeletal Muscle Regeneration

Discoveries, 2019
Skeletal muscle tissue has inherent capacity for regeneration in response to minor injuries. However, in the case of severe trauma, tumor ablations, or in congenital muscle defects, these myopathies can cause irreversible loss of muscle mass and function, a condition referred to as volumetric muscle loss (VML).
Mulbauer, Greta D., Matthew, Howard W.T.
openaire   +2 more sources

SWIR Fluorescence Imaging In Vivo Monitoring and Evaluating Implanted M2 Macrophages in Skeletal Muscle Regeneration

Engineering
Skeletal muscle has a robust regeneration ability that is impaired by severe injury, disease, and aging, resulting in a decline in skeletal muscle function.
Mo Chen, Yuzhou Chen, Sijia Feng, Shixian Dong, Luyi Sun, Huizhu Li, Fuchun Chen, Nguyen Thi Kim Thanh, Yunxia Li, Shiyi Chen, You Wang, Jun Chen   +11 more
doaj   +1 more source

Mechanisms of cooperative cell-cell interactions in skeletal muscle regeneration

Inflammation and Regeneration, 2022
Skeletal muscles have an extraordinary capacity to regenerate themselves when injured. Skeletal muscle stem cells, called satellite cells, play a central role in muscle regeneration via three major steps: activation, proliferation, and differentiation ...
Hiroyuki Koike, Ichiro Manabe, Yumiko Oishi   +2 more
doaj   +1 more source

Cellular Players in Skeletal Muscle Regeneration [PDF]

BioMed Research International, 2014
Skeletal muscle, a tissue endowed with remarkable endogenous regeneration potential, is still under focused experimental investigation mainly due to treatment potential for muscle trauma and muscular dystrophies. Resident satellite cells with stem cell features were enthusiastically described quite a long time ago, but activation of these cells is not ...
Ceafalan, Laura Cristina, Popescu, Bogdan Ovidiu, Hinescu, Mihail Eugen   +2 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source