Long and very long lamellar phases in model stratum corneum lipid membranes
Journal of Lipid Research, 2019 Membrane models of the stratum corneum (SC) lipid barrier, either healthy or affected by recessive X-linked ichthyosis, constructed from ceramide [Cer; nonhydroxyacyl sphingosine N-tetracosanoyl-d-erythro-sphingosine (CerNS24) alone or with omega-O ...
Petra Pullmannová +7 more
doaj +1 more source
Skin Barrier Dysregulation in Psoriasis [PDF]
International Journal of Molecular Sciences, 2021 The skin barrier is broadly composed of two elements—a physical barrier mostly localised in the epidermis, and an immune barrier localised in both the dermis and epidermis. These two systems interact cooperatively to maintain skin homeostasis and overall human health. However, if dysregulated, several skin diseases may arise.
Andreas Orsmond +4 more
openaire +2 more sources
The Epidermal Barrier Structure and Function of Re-Harvested Skin from Non-Scalp Donor Sites
Journal of Investigative Surgery, 2023 Aim The aim of this study was to explore the epidermal barrier structure and function of re-harvested skin from non-scalp donor sites. Methods Six patients with large-area deep burns who met the inclusion and exclusion criteria were subjected to split ...
Bohan Zhang +10 more
doaj +1 more source
By protecting against cutaneous inflammation, epidermal pigmentation provided an additional advantage for ancestral humans. [PDF]
, 2019 Pigmentation evolved in ancestral humans to protect against toxic, ultraviolet B irradiation, but the question remains: "what is being protected?" Because humans with dark pigmentation display a suite of superior epidermal functions in comparison with ...
Abuabara, Katrina +7 more
core +1 more source
Molecular organization and in situ assembly of the human skin barrier [PDF]
, 2016 A deficient skin barrier function is a characteristic feature of skin diseases such as eczema, psoriasis and the ichtyoses. A malformation of the lipid matrix might be a major factor in barrier deficient skin disease.
Hollander, Lianne den
core +1 more source
Skin Microbiome Composition and Key Factors of its Barrier Function
Вопросы современной педиатрии, 2023 The skin is the largest organ of the human body, it creates protective barrier between the internal and external environment. Skin barrier damage may result in homeostasis imbalance, inflammation, or bacterial infection.
Nikolay N. Murashkin +7 more
doaj +1 more source
The Phenion (R) Full-Thickness Skin Model for Percutaneous Absorption Testing [PDF]
, 2010 In recent years many efforts have been made to replace dermal toxicity testing of chemicals in the animal by in vitro assays. As a member of a German research consortium, we have previously contributed to the validation of an in vitro test protocol for ...
Ackermann, K. +4 more
core +1 more source
Physiological and Molecular Effects of in vivo and ex vivo Mild Skin Barrier Disruption [PDF]
, 2018 The success of topically applied treatments on skin relies on the efficacy of skin penetration. In order to increase particle or product penetration, mild skin barrier disruption methods can be used.
Blume-Peytavi, Ulrike +6 more
core +1 more source
Lysosphingolipids in ceramide-deficient skin lipid models
Journal of Lipid ResearchCeramides are key components of the skin's permeability barrier. In atopic dermatitis, pathological hydrolysis of ceramide precursors - glucosylceramides and sphingomyelin - into lysosphingolipids, specifically glucosylsphingosine (GS) and sphingosine ...
Georgios Paraskevopoulos +8 more
doaj +1 more source
Revealing the Correlation between Altered Skin Lipids Composition and Skin Disorders
Cosmetics, 2021 Human skin layers serve as a barrier between the body and the environment, by preventing water loss and blocking the entry of chemicals, allergens, and microbes.
Katerina Drakou +4 more
doaj +1 more source