Results 31 to 40 of about 3,518,709 (352)

Aquaporins Are One of the Critical Factors in the Disruption of the Skin Barrier in Inflammatory Skin Diseases

International Journal of Molecular Sciences, 2022
The skin is the largest organ of the human body, serving as an effective mechanical barrier between the internal milieu and the external environment.
P. Tricarico, D. Mentino, A. De Marco, C. Del Vecchio, Sabino Garra, Gerardo Cazzato, C. Foti, S. Crovella, G. Calamita   +8 more
semanticscholar   +1 more source

Dermal Delivery of the High-Molecular-Weight Drug Tacrolimus by Means of Polyglycerol-Based Nanogels [PDF]

, 2019
Polyglycerol-based thermoresponsive nanogels (tNGs) have been shown to have excellent skin hydration properties and to be valuable delivery systems for sustained release of drugs into skin.
Blume-Peytavi, Ulrike, Calderón, Marcelo, Giulbudagian, Michael, Kleuser, Burkhard, Rancan, Fiorenza, Schumacher, Fabian, Stanko, Jessica Isolde, Vogt, Annika, Volkmann, Hildburg   +8 more
core   +3 more sources

Enhancement of stratum corneum lipid structure improves skin barrier function and protects against irritation in adults with dry, eczema‐prone skin

British Journal of Dermatology, 2021
The skin of patients with atopic dermatitis is characterized by abnormal stratum corneum lipid levels. Consequently, the lamellar matrices are disrupted and skin barrier function is diminished, increasing skin sensitivity to irritants and allergens.
S. Danby, P. Andrew, L. Kay, A. Pinnock, J. Chittock, Kirsty Brown, S. Williams, M. Cork   +7 more
semanticscholar   +1 more source

Water permeation through stratum corneum lipid bilayers from atomistic simulations [PDF]

, 2009
Stratum corneum, the outermost layer of skin, consists of keratin filled rigid non-viable corneocyte cells surrounded by multilayers of lipids. The lipid layer is responsible for the barrier properties of the skin.
Bemporad, Berendsen, Berger, Blank, Bondi, Bouwstra, Chinmay Das, Chiu, Das, den Otter, Falck, Farwanah, Golden, Hara, Hoover, Hänggi, Höltje, Jacobson, Jorgensen, Kasting, Lodén, Mark, Marrink, Massimo G. Noro, Michaels, Miyamoto, Norlén, Norlén, Nosé, Nosé, Notman, Parrinello, Peter D. Olmsted, Pieper, Potts, Prausnitz, Ryckaert, Ryckaert, Schatzberg, Scheuplein, Schätzlein, Sugii, van der Spoel, Weerheim   +43 more
core   +2 more sources

Permeability Barrier and Microstructure of Skin Lipid Membrane Models of Impaired Glucosylceramide Processing

Scientific Reports, 2017
Ceramide (Cer) release from glucosylceramides (GlcCer) is critical for the formation of the skin permeability barrier. Changes in β-glucocerebrosidase (GlcCer’ase) activity lead to diminished Cer, GlcCer accumulation and structural defects in SC lipid ...
Michaela Sochorová, Klára Staňková, Petra Pullmannová, Andrej Kováčik, Jarmila Zbytovská, Kateřina Vávrová   +5 more
doaj   +1 more source

Proderm technology: a water- based lipid delivery system for dermatitis that penetrates viable epidermis and has antibacterial effects. [PDF]

, 2019
BackgroundA defective skin barrier and bacterial colonization are two important factors in maintenance and progression of atopic dermatitis and chronic allergic/irritant hand dermatitis.
Caputo-Janhager, Melinda, Charruyer, Alexandra, Ghadially, Ruby, Raymond, Isabelle, Silvander, Mats   +4 more
core   +3 more sources

Cannabinoids and Inflammations of the Gut-Lung-Skin Barrier

Journal of Personalized Medicine, 2021
Recent studies have identified great similarities and interferences between the epithelial layers of the digestive tract, the airways and the cutaneous layer.
C. Scheau, C. Caruntu, I. Bădărău, A. Scheau, A. Docea, D. Calina, A. Căruntu   +6 more
semanticscholar   +1 more source

The Importance of Hydration in Wound Healing: Reinvigorating the clinical perspective [PDF]

, 2016
Balancing skin hydration levels is important as any disruption in skin integrity will result in disturbance of the dermal water balance. The discovery that a moist wound healing environment actively supports the healing response when compared to a dry ...
Atiyeh B.S., Atiyeh B.S., Eaglstein W.H., Faria D., Gabriel A., Gabriel A., Gray D., Hebra F., Leung B.K., Park A.C., Rubio P.A., Scheuplein R., Verdier-Sévrain S., Xu W., Zelen C.M.   +14 more
core   +1 more source

Ex Vivo Live Full-Thickness Porcine Skin Model as a Versatile In Vitro Testing Method for Skin Barrier Research

International Journal of Molecular Sciences, 2021
Since the European Union (EU) announced their animal testing ban in 2013, all animal experiments related to cosmetics have been prohibited, creating a demand for alternatives to animal experiments for skin studies.
Jee-hyun Hwang, Haengdueng Jeong, Nahyun Lee, Sumin Hur, Nakyum Lee, Jeong Jun Han, H. Jang, W. Choi, K. Nam, Kyung-Min Lim   +9 more
semanticscholar   +1 more source

Ceramides in the skin barrier

European Pharmaceutical Journal, 2017
The skin barrier, which is essential for human survival on dry land, is located in the uppermost skin layer, the stratum corneum. The stratum corneum consists of corneocytes surrounded by multilamellar lipid membranes that prevent excessive water loss ...
Vávrová K., Kováčik A., Opálka L.
doaj   +1 more source