Physiological and Molecular Effects of in vivo and ex vivo Mild Skin Barrier Disruption [PDF]
, 2018 The success of topically applied treatments on skin relies on the efficacy of skin penetration. In order to increase particle or product penetration, mild skin barrier disruption methods can be used.
Blume-Peytavi, Ulrike +6 more
core +1 more source
The Phenion (R) Full-Thickness Skin Model for Percutaneous Absorption Testing [PDF]
, 2010 In recent years many efforts have been made to replace dermal toxicity testing of chemicals in the animal by in vitro assays. As a member of a German research consortium, we have previously contributed to the validation of an in vitro test protocol for ...
Ackermann, K. +4 more
core +1 more source
Lysosphingolipids in ceramide-deficient skin lipid models
Journal of Lipid ResearchCeramides are key components of the skin's permeability barrier. In atopic dermatitis, pathological hydrolysis of ceramide precursors - glucosylceramides and sphingomyelin - into lysosphingolipids, specifically glucosylsphingosine (GS) and sphingosine ...
Georgios Paraskevopoulos +8 more
doaj +1 more source
Revealing the Correlation between Altered Skin Lipids Composition and Skin Disorders
Cosmetics, 2021 Human skin layers serve as a barrier between the body and the environment, by preventing water loss and blocking the entry of chemicals, allergens, and microbes.
Katerina Drakou +4 more
doaj +1 more source
Interplay of Staphylococcal and Host Proteases Promotes Skin Barrier Disruption in Netherton Syndrome. [PDF]
, 2020 Netherton syndrome (NS) is a monogenic skin disease resulting from loss of function of lymphoepithelial Kazal-type-related protease inhibitor (LEKTI-1).
Butcher, Anna M +12 more
core
Further development of an in vitro model for studying the penetration of chemicals through compromised skin [PDF]
, 2016 A new in vitro model based on the electrical resistance properties of the skin barrier has been established in this laboratory. The model utilises a tape stripping procedure in dermatomed pig skin that removes a specific proportion of the stratum corneum,
Davies, D +4 more
core +2 more sources
Liquid-liquid phase separation drives skin barrier formation
Science, 2020 Phase separation can be skin deep The skin's barrier arises from proliferative cells that generate a perpetual upward flux of terminally differentiating epidermal cells.
Felipe Garcia Quiroz +6 more
semanticscholar +1 more source
Research Techniques Made Simple:Transepidermal Water Loss Measurement as a Research Tool [PDF]
, 2018 Transepidermal water loss (TEWL) is the most widely used objective measurement for assessing the barrier function of skin in healthy individuals but also patients with skin diseases that are associated with skin barrier dysfunction, such as atopic ...
Alexander, Helen +3 more
core +2 more sources
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Barrier dysfunction in the skin allergy
Allergology International, 2018 The skin is continuously exposed to external pathogens, and its barrier function is critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one of the most predisposing factors for the development of skin allergic ...
Gyohei Egawa, Kenji Kabashima
doaj +1 more source