Results 11 to 20 of about 22,408 (233)

3D Approaches to Culturing Bovine Skin: Explant Culture versus Organotypic Skin Model.

Cells Tissues Organs
Introduction: Digital dermatitis (DD) in cattle appears with high prevalence; nevertheless, the knowledge on its pathogenesis is still limited. In this context, in vitro skin models represent a valuable tool to facilitate the study of DD. Methods: Two in vitro skin models were established using bovine distal limb skin: a skin explant model and an ...
Baumbach CM, Anantama NA, Savkovic V, Mülling CKW, Schinköthe J, Michler JK.   +5 more
europepmc   +3 more sources

Efficacy of a novel thermo-reversible wound gel against antibiotic tolerant biofilm [PDF]

Frontiers in Antibiotics
Chronic wounds are frequently colonized by biofilm-forming bacteria, and one of the defining characteristics of these infections is the resulting tolerance to antibiotics. A novel thermo-reversible antimicrobial wound gel (revyve® Antimicrobial Wound Gel,
Jeyachchandran Visvalingam, Anna Muzaleva, Miloslav Sailer, Sarvesh Logsetty, Robert B. Huizinga   +4 more
doaj   +2 more sources

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming [PDF]

FEBS Open Bio
Primary fibroblasts are widely used in a variety of experimental and therapeutic studies. Patient‐derived skin biopsies are an accessible way to generate dermal fibroblasts for wound and burn therapeutics and can be easily reprogrammed to induced ...
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
doaj   +2 more sources

Analysis of Circadian Clock Gene Expression in Human Skin Explants

JID Innovations
Many aspects of skin biochemistry and physiology are known to vary over the course of the 24-hour day. Traditional approaches to study circadian rhythms in the skin have employed rodents or human subjects, which limit the experimental variables that can ...
William Cvammen, Michael G. Kemp
doaj   +3 more sources

Characterization of a pathogenic nonmigratory fibroblast population in systemic sclerosis skin [PDF]

JCI Insight
Fibroblasts are central to pathogenesis of systemic sclerosis (SSc). However, studies of conventional explant fibroblast cultures incompletely reflect disease biology and treatment response.
Kristina E.N. Clark, Shiwen Xu, Moustafa Attar, Voon H. Ong, Christopher D. Buckley, Christopher P. Denton   +5 more
doaj   +2 more sources

Sphingosine 1-phosphate modulates antigen capture by murine langerhans cells via the S1P2 receptor subtype [PDF]

, 2012
Dendritic cells (DCs) play a pivotal role in the development of cutaneous contact hypersensitivity (CHS) and atopic dermatitis as they capture and process antigen and present it to T lymphocytes in the lymphoid organs.
A Kihara, A Kissenpfennig, A Kumar, A Martino, A Olivera, A Weigert, AD Christensen, Burkhard Kleuser, C Ocana-Morgner, C Ruedl, CC Norbury, CL Bennett, CL Bennett, DH Kaplan, DH Kaplan, E Guaguere, ES Trombetta, EY Seo, F Sparber, G Gollmann, G Schuhmachers, H Hackstein, H Liu, Heinfried H. Radeke, HH Radeke, I Reines, J Chun, Jagadeesh Bayry, JH Hong, K Kabashima, K Sarkar, K Takabe, Katrin Schaper, L Japtok, L Rose, L Ruwisch, LS Bursch, Lukasz Japtok, M Hara-Chikuma, M Matloubian, M Schröder, M Schuppel, MB Lutz, MC Kerr, ML Allende, ML Allende, N Romani, P Mitra, P Monti, R van de Ven, RH Kim, RM Steinman, S Spiegel, S Sullivan, S Xu, Se Kyoo Jeong, SH Wood, SP Zahner, T Hla, T Kitajima, T Walzer, V Brinkmann, W Baumer, W Baumer, W Baumer, Wolfgang Bäumer, Y Maeda, Y Yanagawa, YY Lan   +68 more
core   +10 more sources

Anti-Inflammatory and Antioxidant Effects of Diosmetin-3-O-β-d-Glucuronide, the Main Metabolite of Diosmin: Evidence from Ex Vivo Human Skin Models

Molecules, 2023
Diosmin is used to relieve chronic venous disease (CVD) symptoms. This study aimed to investigate the anti-inflammatory and antioxidant effects of diosmetin-3-O-β-d-glucuronide, the major metabolite of diosmin, using human skin explants.
Sylvie Boisnic, Marie-Christine Branchet, Barbara Quioc-Salomon, Julie Doan, Catherine Delva, Célia Gendron   +5 more
doaj   +1 more source

Expression profiling of major histocompatibility and natural killer complex genes reveals candidates for controlling risk of graft versus host disease. [PDF]

PLoS ONE, 2011
The major histocompatibility complex (MHC) is the most important genomic region that contributes to the risk of graft versus host disease (GVHD) after haematopoietic stem cell transplantation.
Peter Novota, Severin Zinöcker, Jean Norden, Xiao Nong Wang, Lisbet Sviland, Lennart Opitz, Gabriela Salinas-Riester, Bent Rolstad, Anne M Dickinson, Lutz Walter, Ralf Dressel   +10 more
doaj   +1 more source

Ferulic Acid Induces Keratin 6α via Inhibition of Nuclear β-Catenin Accumulation and Activation of Nrf2 in Wound-Induced Inflammation

Biomedicines, 2021
Injured tissue triggers complex interactions through biological process associated with keratins. Rapid recovery is most important for protection against secondary infection and inflammatory pain.
Kang-Hoon Kim, Ji Hoon Jung, Won-Seok Chung, Chang-Hun Lee, Hyeung-Jin Jang   +4 more
doaj   +1 more source

Neryl acetate, the major component of Corsican Helichrysum italicum essential oil, mediates its biological activities on skin barrier.

PLoS ONE, 2023
Corsican Helichrysum italicum essential oil (HIEO) is characterized by high concentrations of neryl acetate, and we previously demonstrated that Corsican HIEO increases the expression of genes that are part of the differentiation complex (involucrin ...
Géraldine Lemaire, Malvina Olivero, Virginie Rouquet, Alain Moga, Aurélie Pagnon, Valérie Cenizo, Pascal Portes   +6 more
doaj   +1 more source