Results 21 to 30 of about 12,047 (235)

Anti-Inflammatory and Antioxidant Effects of Diosmetin-3-O-β-d-Glucuronide, the Main Metabolite of Diosmin: Evidence from Ex Vivo Human Skin Models

Molecules, 2023
Diosmin is used to relieve chronic venous disease (CVD) symptoms. This study aimed to investigate the anti-inflammatory and antioxidant effects of diosmetin-3-O-β-d-glucuronide, the major metabolite of diosmin, using human skin explants.
Sylvie Boisnic, Marie-Christine Branchet, Barbara Quioc-Salomon, Julie Doan, Catherine Delva, Célia Gendron   +5 more
doaj   +1 more source

Expression profiling of major histocompatibility and natural killer complex genes reveals candidates for controlling risk of graft versus host disease. [PDF]

PLoS ONE, 2011
The major histocompatibility complex (MHC) is the most important genomic region that contributes to the risk of graft versus host disease (GVHD) after haematopoietic stem cell transplantation.
Peter Novota, Severin Zinöcker, Jean Norden, Xiao Nong Wang, Lisbet Sviland, Lennart Opitz, Gabriela Salinas-Riester, Bent Rolstad, Anne M Dickinson, Lutz Walter, Ralf Dressel   +10 more
doaj   +1 more source

Ferulic Acid Induces Keratin 6α via Inhibition of Nuclear β-Catenin Accumulation and Activation of Nrf2 in Wound-Induced Inflammation

Biomedicines, 2021
Injured tissue triggers complex interactions through biological process associated with keratins. Rapid recovery is most important for protection against secondary infection and inflammatory pain.
Kang-Hoon Kim, Ji Hoon Jung, Won-Seok Chung, Chang-Hun Lee, Hyeung-Jin Jang   +4 more
doaj   +1 more source

Neryl acetate, the major component of Corsican Helichrysum italicum essential oil, mediates its biological activities on skin barrier.

PLoS ONE, 2023
Corsican Helichrysum italicum essential oil (HIEO) is characterized by high concentrations of neryl acetate, and we previously demonstrated that Corsican HIEO increases the expression of genes that are part of the differentiation complex (involucrin ...
Géraldine Lemaire, Malvina Olivero, Virginie Rouquet, Alain Moga, Aurélie Pagnon, Valérie Cenizo, Pascal Portes   +6 more
doaj   +1 more source

3D skin models in domestic animals

Veterinary Research, 2021
The skin is a passive and active barrier which protects the body from the environment. Its health is essential for the accomplishment of this role. Since several decades, the skin has aroused a strong interest in various fields (for e.g.
Laurent Souci, Caroline Denesvre
doaj   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Enhanced Isolation of Fibroblasts from Human Skin Explants

BioTechniques, 2012
Here we describe a method for growing fibroblasts from human skin explants that increases the number of cells obtained by up to two orders of magnitude, thus increasing the amount of material available for research and diagnostic purposes and potentially for cell-based therapies.
Lily I. Huschtscha, Christine E. Napier, Jane R. Noble, Kylie Bower, Amy Y.M. Au, Hamish G. Campbell, Antony W. Braithwaite, Roger R. Reddel   +7 more
openaire   +3 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Improvement of Cell Culture Methods for the Successful Generation of Human Keratinocyte Primary Cell Cultures Using EGF-Loaded Nanostructured Lipid Carriers

Biomedicines, 2021
Human skin keratinocyte primary cultures can be established from skin biopsies with culture media containing epithelial growth factor (EGF). Although current methods are efficient, optimization is required to accelerate the procedure and obtain these ...
Jesús Chato-Astrain, David Sánchez-Porras, Óscar Darío García-García, Claudia Vairo, María Villar-Vidal, Silvia Villullas, Indalecio Sánchez-Montesinos, Fernando Campos, Ingrid Garzón, Miguel Alaminos   +9 more
doaj   +1 more source

KULTUR PRIMER FIBROBLAS: PENELITIAN PENDAHULUAN

Majalah Kedokteran Andalas, 2015
AbstrakKultur sel fibroblas banyak digunakan untuk penelitian proses penyembuhan luka dan penuaankulit. Metode ini digunakan untuk melihat perkembangan sel, proliferasi kinetik seluler, sertabiosintesis komponen matriks ekstraseluler.
Yuli Kurniawati, Sudigdo Adi, Achadiyani Achadiyani, Oki Suwarsa, Dimas Erlangga, Tenny Putri   +5 more
doaj   +1 more source