Results 11 to 20 of about 12,047 (235)

Early skin colonization by Staphylococcus epidermidis and Staphylococcus aureus reveals environment-dependent synergistic effects [PDF]

Frontiers in Microbiology
IntroductionThe skin microbiome is crucial for skin health and homeostasis. It contributes to immune defense, promotes epidermal differentiation, and supports a robust skin barrier function.
Chrisse Ngari, Valérie Poulet, Giuseppe Percoco, Laurent Peno-Mazzarino, Damien Seyer   +4 more
doaj   +2 more sources

3D Approaches to Culturing Bovine Skin: Explant Culture versus Organotypic Skin Model.

Cells Tissues Organs
Introduction: Digital dermatitis (DD) in cattle appears with high prevalence; nevertheless, the knowledge on its pathogenesis is still limited. In this context, in vitro skin models represent a valuable tool to facilitate the study of DD. Methods: Two in vitro skin models were established using bovine distal limb skin: a skin explant model and an ...
Baumbach CM, Anantama NA, Savkovic V, Mülling CKW, Schinköthe J, Michler JK.   +5 more
europepmc   +3 more sources

TIGIT agonism as a therapeutic strategy to suppress inflammation in hidradenitis suppurativa [PDF]

Frontiers in Immunology
Hidradenitis suppurativa (HS) is a chronic, heterogeneous inflammatory skin disorder with limited therapeutic options. The immune checkpoint receptor TIGIT is emerging as a regulator of chronic inflammation, yet its role in HS remains unknown.
Michal Kidacki, Anjali Jaiswal, Christina Cho, Samantha Prince, Rachel Breidbart, Henry Hsia, Matthew D. Vesely, Lieping Chen, Lieping Chen   +8 more
doaj   +2 more sources

An In Vitro Human Skin Test for Predicting Skin Sensitization and Adverse Immune Reactions to Biologics

Toxics
Biologics, including monoclonal antibodies (mAb), have proved to be effective and successful therapeutic agents, particularly in the treatment of cancer and immune-inflammatory conditions, as well as allergies and infections.
Shaheda Sameena Ahmed, Mohammed Mahid Ahmed, Abbas Ishaq, Matthew Freer, Richard Stebbings, Anne Mary Dickinson   +5 more
doaj   +2 more sources

Functional human skin explants as tools for assessing mast cell activation and inhibition [PDF]

Frontiers in Allergy
Mast cells are activated through a variety of different receptors to release preformed granules and mediators synthesized de novo. However, the physiology and function of mast cells are not fully understood. Traditional studies of mast cell activation in
Clarence Rachel Villanueva, Keane Barksdale, Tinuola Owolabi, Donavan Bridges, Kristin Chichester, Sarbjit Saini, Eric T. Oliver   +6 more
doaj   +2 more sources

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming [PDF]

FEBS Open Bio
Primary fibroblasts are widely used in a variety of experimental and therapeutic studies. Patient‐derived skin biopsies are an accessible way to generate dermal fibroblasts for wound and burn therapeutics and can be easily reprogrammed to induced ...
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
doaj   +2 more sources

Trihydroxybenzoic acid glucoside as a global skin color modulator and photo-protectant

Clinical, Cosmetic and Investigational Dermatology, 2015
Hanane Chajra,1 Gérard Redziniak,2 Daniel Auriol,3 Kuno Schweikert,1 Fabrice Lefevre1 1Induchem AG, Volkestwil, Switzerland; 2Cosmetic Invention, Antony, 3Libragen SA, Toulouse, France Background: 3,4,5-Trihydroxybenzoic acid glucoside (THBG), a ...
Chajra H, Redziniak G, Auriol D, Schweikert K, Lefevre F   +4 more
doaj   +1 more source

Analysis of Circadian Clock Gene Expression in Human Skin Explants

JID Innovations
Many aspects of skin biochemistry and physiology are known to vary over the course of the 24-hour day. Traditional approaches to study circadian rhythms in the skin have employed rodents or human subjects, which limit the experimental variables that can ...
William Cvammen, Michael G. Kemp
doaj   +3 more sources

Influence of Injectable Hyaluronic Gel System on Skin Microbiota, Skin Defense Mechanisms and Integrity (Ex vivo Study)

Clinical, Cosmetic and Investigational Dermatology
Aleksei Y Prokopov,1,2 Zarema I Gazitaeva,1 Anna N Sidorina,1 Laurent Peno-Mazzarino,3 Nikita Radionov,3 Anna O Drobintseva,4 Igor M Kvetnoy5 1Medical Bioengineering Systems LLC, Moscow, Russia; 2Laboratoires Fijie SAS, Paris, France; 3Eurofins BIO-EC ...
Prokopov AY, Gazitaeva ZI, Sidorina AN, Peno-Mazzarino L, Radionov N, Drobintseva AO, Kvetnoy IM   +6 more
doaj   +2 more sources

A skin explant model for studying UV ‐induced DNA damage and repair [PDF]

Photochemistry and Photobiology
Shiyong Wu, Veronica A Bahamondes Lorca
exaly   +2 more sources