Results 41 to 50 of about 12,047 (235)
Establish a teleost skin explant model for studying the fish-pathogen interaction
, 2021 Teleost fish skin serves as the first line of defense against pathogens. The interaction between pathogen and host skin determines the infection outcome. However, the mechanism(s) that modulate infection remain largely unknown.
Siao, Ru-Fang
core
Advanced Healthcare Materials, EarlyView.The incorporation of nondigested ECM and synthetic polymers into a co‐electrospinning system enables the decoupling of bioactivity and mechanical properties within a single wrap. This technique is used to develop a multifunctional bone wrap that achieves augmented membrane durability, sustained infection control, and enhanced vascularity for use in ...
Sarah Jones +14 more
wiley +1 more source
T cells fail to develop in the human skin-cell explants system; an inconvenient truth
BMC Immunology, 2011 Background Haplo-identical hematopoietic stem cell (HSC) transplantation is very successful in eradicating haematological tumours, but the long post-transplant T-lymphopenic phase is responsible for high morbidity and mortality rates. Clark et al.
Vanderlocht Joris +10 more
doaj +1 more source
Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin
Nature Communications, 2023 Inhibition of Janus kinase (JAK) family enzymes is a popular strategy for treating inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK inhibitors show distinct efficacy and safety profiles, likely reflecting variable selectivity ...
Qi Tang +35 more
doaj +1 more source
Skin protective and regenerative effects of RM191A, a novel superoxide dismutase mimetic
Redox Biology, 2021 Superoxide dismutase (SOD) is known to be protective against oxidative stress-mediated skin dysfunction. Here we explore the potential therapeutic activities of RM191A, a novel SOD mimetic, on skin.
Artur Shariev +15 more
doaj +1 more source
Long‐Term Hydrophilic, Anti‐Clotting, and Anti‐Fibrotic Dynamic Covalent Silicone‐Based Biomaterials
Advanced Healthcare Materials, EarlyView.Dynamic covalent crosslinking of a Schiff‐base silicone elastomer with hydrazide‐functionalized polymers is demonstrated to improve the long‐term hydrophilicity as well as the anti‐fouling and anti‐clotting properties of PDMS implants. The hydrazone‐functionalized material prevents hydrophobic recovery, resists clotting, and significantly reduces ...
Norma A. Garza Flores +12 more
wiley +1 more source
Advanced Science, EarlyView.By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao +11 more
wiley +1 more source
Growth and Differentiation of Postembryonic Mouse Epidermal Cells in Explant Cultures
, 1979 Until now the only successful growth of postembryonic skin in explant cultures has been with human skin. We describe the successful cultivation of postembryonic mouse skin in explant culture in this report.
Halprin, Kenneth M +2 more
core +1 more source
MethodsX, 2022 Skin is an important interface with the external environment and investigating amphibian skin cell biology will improve our understanding of how environmental factors such as pathogens and pollutants are contributing to global amphibian declines.
Maxwell P. Bui-Marinos +3 more
doaj +1 more source
Advanced Science, EarlyView.This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang +12 more
wiley +1 more source