Results 51 to 60 of about 497,473 (285)

O contextualismo linguístico na história do pensamento político: Quentin Skinner e o debate metodológico contemporâneo

open access: yesDados: Revista de Ciências Sociais, 2010
Dans cet article, on souhaite situer et examiner le débat méthodologique proposé par l'École de Cambridge au sujet de l'histoire de la pensée politique dans les quatre dernières décennies, tout en insistant sur les positions de Quentin Skinner et les ...
Ricardo Silva
doaj   +1 more source

A Direct Proof of BCFW Recursion for Twistor-Strings

open access: yes, 2010
This paper gives a direct proof that the leading trace part of the genus zero twistor-string path integral obeys the BCFW recursion relation. This is the first complete proof that the twistor-string correctly computes all tree amplitudes in maximally ...
Skinner, David
core   +1 more source

Lagrangian-Hamiltonian unified formalism for field theory [PDF]

open access: yes, 2004
The Rusk-Skinner formalism was developed in order to give a geometrical unified formalism for describing mechanical systems. It incorporates all the characteristics of Lagrangian and Hamiltonian descriptions of these systems (including dynamical ...
Arturo Echeverrı́a-Enrı́quez   +26 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Chandra Observations of WR147 Reveal a Double X-ray Source

open access: yes, 2009
We report the first results from deep X-ray observations of the Wolf-Rayet binary system WR147 with the Chandra HETG. Analysis of the zeroth order data reveals that WR147 is a double X-ray source.
Arnaud   +16 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Significado e interpretação na História das Ideias

open access: yesTempo e Argumento, 2017
Tradução do Capítulo 4 da obra: SKINNER, Quentin. Meaning and Understanding in the History of Ideas. In: SKINNER, Quentin. Visions of Politics. Londres: Cambridge University Press, 2001, vol. I, cap. 4, p. 57-89.
Quentin Skinner
doaj   +1 more source

Composers' Forum: Student Works, March 27, 1990 [PDF]

open access: yes, 1990
This is the concert program of the Composers' Forum: Student Works performance on Tuesday, March 27, 1990 at 12:30 p.m., at the Boston University Concert Hall, 855 Commonwealth Avenue, Boston, Massachusetts. Works performed were Dancers by David Skinner,
School of Music, Boston University
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

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