Results 1 to 10 of about 2,152 (193)

Structure and transport mechanism of the human prostaglandin transporter SLCO2A1 [PDF]

Nature Communications
SLCO2A1 is a member of the organic anion transporting polypeptide (OATP) family, which preferentially transports prostaglandins (PGs) into cells and plays a vital role in regulating PGs inactivation and distribution.
Zhanyi Xia, Guangyuan Lu, Di Wu, Jun Zhao, Bowen Zhang, Haoran Xu, Yingying Du, Daohua Jiang   +7 more
doaj   +3 more sources

Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis [PDF]

PLoS ONE, 2015
Prostaglandin (PG) E2 exhibits an anti-fibrotic effect in the lung in response to inflammatory reactions and is a high-affinity substrate of PG transporter (SLCO2A1).
Takeo Nakanishi, Hisakazu Komori, Ken-Ichi Hosoya   +2 more
exaly   +5 more sources

Label-free detection of prostaglandin transporter (SLCO2A1) function and inhibition: insights by wound healing and TRACT assays [PDF]

Frontiers in Pharmacology
The prostaglandin transporter (PGT, SLCO2A1) mediates transport of prostanoids (a.o. prostaglandin E2 (PGE2)) into cells and thereby promotes their degradation.
Adriaan P Ijzerman, Tamara A M Mocking
exaly   +4 more sources

Differential Expression Patterns of SLCO Solute Carriers in Human Breast Cancer Cell Lines and Tumour Samples. [PDF]

J Cell Mol Med
ABSTRACT The cellular uptake of nutrients essential for cell growth and survival is facilitated by solute carrier (SLC) transporters. Members of the SLCO subfamily of SLCs mediate the uptake of substrates relevant to breast cancer (BC), including steroid hormones and anticancer drugs.
Telfer-Sutherland R, Page L, Meeson A, Lowes S.   +3 more
europepmc   +2 more sources

Structural basis for prostaglandin and drug transport via SLCO2A1 [PDF]

Nature Communications
Organic anion-transporting polypeptide transporters (SLCO/OATPs) function as cellular gatekeepers, regulating intestinal absorption, hepatic and renal clearance, and the tissue distribution of drugs and metabolites in the human body.
Chitra Joshi, Justin C. Deme, Yoshinobu Nakamura, Wei-Tse Hsu, Jonathan D. Goult, Takafumi Kato, Joanne L. Parker, Philip C. Biggin, Susan M. Lea, Takeo Nakanishi, Simon Newstead   +10 more
doaj   +2 more sources

A novel mutation in the SLCO2A1 gene presenting as persistent hypoproteinaemia and refractory iron deficiency anaemia due to chronic enteropathy: a case report [PDF]

BMC Pediatrics
Background The SLCO2A1 gene encodes a prostaglandin transporter and we report a novel mutation causing hypoproteinaemia and refractory anaemia due to chronic enteropathy. Case presentation An 18-year-old boy of consanguineous parents was investigated for
Sachith Mettananda, PKBUC Bandara, Manissha Rajeindran, Padmapani Padeniya   +3 more
doaj   +2 more sources

A pediatric patient with chronic enteropathy associated with SLCO2A1 who underwent multimodal treatment including several surgeries: a case report [PDF]

Frontiers in Surgery
IntroductionChronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare protein-losing enteropathy primarily recognized in Asia. Its uncommon nature and limited research usually complicate diagnosis and treatment. This review examines the course of
Yoojin Jung, Jaehee Chung, Inhyuk Yoo
doaj   +2 more sources

Clinical and genetic characteristics of Chinese patients diagnosed with chronic enteropathy associated with SLCO2A1 gene [PDF]

Orphanet Journal of Rare Diseases
Background and aims Chronic enteropathy associated with SLCO2A1 gene is a rare intestinal disease caused by loss-of-function SLCO2A1 mutations, with clinical and genetic characteristics remaining largely unknown, especially in Chinese patients.
Qing Shang, Yimin Dai, Jingyi Huang, Wei Liu, Weixun Zhou, Yaping Liu, Hong Yang, Qiang Wang, Yue Li   +8 more
doaj   +2 more sources

Intratumoral <i>Fusobacterium nucleatum</i> Drives Cancer-Associated Fibroblasts Enrichment and Immune Exclusion in Esophageal Squamous Cell Carcinoma. [PDF]

Ann Gastroenterol Surg
Fusobacterium nucleatum contributes to the progression of ESCC by inducing NF‐κB–mediated inflammatory signaling in tumor cells and promoting CAFs activation. Its presence may facilitate immune exclusion and tumor invasion through stromal remodeling. Furthermore, F.
Ofuchi T, Hu Q, Omachi K, Kanemitsu K, Otsu H, Yonemura Y, Tobo T, Baba Y, Iwatsuki M, Mimori K.   +9 more
europepmc   +2 more sources

Characteristics of chronic enteropathy associated with SLCO2A1 gene (CEAS) in children, a unique type of monogenic very early-onset inflammatory bowel disease [PDF]

BMC Pediatrics
Background  Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a unique type of inflammatory bowel disease. CEAS is monogenic disease and is thought to develop from childhood, but studies on pediatric CEAS are scarce.
Jin Gyu Lim, Jae Sung Ko, Jung Min Ko, Hyun Young Kim, Man Jin Kim, Moon Woo Seong, Young Hun Choi, Gyeong Hoon Kang, Jaemoon Koh, Jin Soo Moon   +9 more
doaj   +2 more sources