Results 1 to 10 of about 1,479 (176)

Structure and transport mechanism of the human prostaglandin transporter SLCO2A1 [PDF]

Nature Communications
SLCO2A1 is a member of the organic anion transporting polypeptide (OATP) family, which preferentially transports prostaglandins (PGs) into cells and plays a vital role in regulating PGs inactivation and distribution.
Zhanyi Xia, Guangyuan Lu, Di Wu, Jun Zhao, Bowen Zhang, Haoran Xu, Yingying Du, Daohua Jiang   +7 more
doaj   +5 more sources

Structural basis for prostaglandin and drug transport via SLCO2A1 [PDF]

Nature Communications
Organic anion-transporting polypeptide transporters (SLCO/OATPs) function as cellular gatekeepers, regulating intestinal absorption, hepatic and renal clearance, and the tissue distribution of drugs and metabolites in the human body.
Chitra Joshi, Justin C. Deme, Yoshinobu Nakamura, Wei-Tse Hsu, Jonathan D. Goult, Takafumi Kato, Joanne L. Parker, Philip C. Biggin, Susan M. Lea, Takeo Nakanishi, Simon Newstead   +10 more
doaj   +6 more sources

Chronic Enteropathy Associated with <italic>SLCO2A1</italic> Gene [PDF]

Inflammatory Intestinal Diseases
Background: Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare hereditary disorder characterized by multiple small intestinal ulcers, chronic anemia, and hypoproteinemia. Initially reported by Okabe et al.
Junji Umeno, Motohiro Esaki, Keiichi Uchida, Takayuki Matsumoto   +3 more
doaj   +4 more sources

A novel mutation in the SLCO2A1 gene presenting as persistent hypoproteinaemia and refractory iron deficiency anaemia due to chronic enteropathy: a case report [PDF]

BMC Pediatrics
Background The SLCO2A1 gene encodes a prostaglandin transporter and we report a novel mutation causing hypoproteinaemia and refractory anaemia due to chronic enteropathy. Case presentation An 18-year-old boy of consanguineous parents was investigated for
Sachith Mettananda, PKBUC Bandara, Manissha Rajeindran, Padmapani Padeniya   +3 more
doaj   +3 more sources

Etoricoxib as a treatment of choice for patients with SLCO2A1 mutation exhibiting autosomal recessive primary hypertrophic osteoarthropathy: A case report [PDF]

Frontiers in Genetics, 2022
We reported a 22-year-old Emirati male with autosomal recessive primary hypertrophic osteoarthropathy caused by a possibly pathogenic homozygous non-synonymous variant in the SLCO2A1 gene (NM_005630.3: c.289C>T, p.
Nadia Akawi, Fatma Al Jasmi
exaly   +4 more sources

Primary hypertrophic osteoarthropathy complicated with myelofibrosis and compound heterozygous SLCO2A1 mutations: a case report and review of literature [PDF]

Frontiers in Oncology
BackgroundPrimary hypertrophic osteoarthropathy (PHO) is a rare hereditary clinical syndrome characterized by digital clubbing, periostosis, and pachydermia.
Qirui Xu, Qian Li, Jin Lu, Jin Lu, Liru Wang   +4 more
doaj   +2 more sources

Biallelic SLCO2A1 variants in two siblings with primary hypertrophic osteoarthropathy and possible chronic enteropathy [PDF]

Frontiers in Endocrinology
Background and aimsPathogenic variants in the SLCO2A1 gene are responsible for two rare monogenic disorders: primary hypertrophic osteoarthropathy (PHO) and chronic enteropathy (CEAS).
Tao Wang, Qian Zhang, Tingting Shi, Xin Chen, Li Wang, Xiuming Liu, Yihui Wang, Kaikai Shen, Fei Zhao, Litao Qin   +9 more
doaj   +2 more sources

Differential Expression Patterns of SLCO Solute Carriers in Human Breast Cancer Cell Lines and Tumour Samples. [PDF]

J Cell Mol Med
ABSTRACT The cellular uptake of nutrients essential for cell growth and survival is facilitated by solute carrier (SLC) transporters. Members of the SLCO subfamily of SLCs mediate the uptake of substrates relevant to breast cancer (BC), including steroid hormones and anticancer drugs.
Telfer-Sutherland R, Page L, Meeson A, Lowes S.   +3 more
europepmc   +2 more sources

A pediatric patient with chronic enteropathy associated with SLCO2A1 who underwent multimodal treatment including several surgeries: a case report [PDF]

Frontiers in Surgery
IntroductionChronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare protein-losing enteropathy primarily recognized in Asia. Its uncommon nature and limited research usually complicate diagnosis and treatment. This review examines the course of
Yoojin Jung, Jaehee Chung, Inhyuk Yoo
doaj   +2 more sources

Clinical and genetic characteristics of Chinese patients diagnosed with chronic enteropathy associated with SLCO2A1 gene [PDF]

Orphanet Journal of Rare Diseases
Background and aims Chronic enteropathy associated with SLCO2A1 gene is a rare intestinal disease caused by loss-of-function SLCO2A1 mutations, with clinical and genetic characteristics remaining largely unknown, especially in Chinese patients.
Qing Shang, Yimin Dai, Jingyi Huang, Wei Liu, Weixun Zhou, Yaping Liu, Hong Yang, Qiang Wang, Yue Li   +8 more
doaj   +2 more sources