Clinical and Genetic Characteristics of Korean Patients Diagnosed with Chronic Enteropathy Associated with SLCO2A1 Gene: A KASID Multicenter Study [PDF]
Gut and Liver, 2022 Background/Aims: Chronic enteropathy associated with SLCO2A1 gene (CEAS), an inherited disease characterized by nonspecific intestinal ulcers, has emerged in the Japanese population via loss-of-function mutations in the SLCO2A1 gene.
Hee Seung Hong +17 more
doaj +3 more sources
Exome Sequencing Identifies SLCO2A1 Mutations as a Cause of Primary Hypertrophic Osteoarthropathy [PDF]
The American Journal of Human Genetics, 2012 By using whole-exome sequencing, we identified a homozygous guanine-to-adenine transition at the invariant −1 position of the acceptor site of intron 1 (c.97−1G>A) in solute carrier organic anion transporter family member 2A1 (SLCO2A1), which encodes a ...
Yue, Hua +13 more
core +4 more sources
Pediatric Rheumatology Online Journal, 2023 Background Primary Hypertrophic Osteoarthropathy (PHO), also known as Touraine-Solente-Gole Syndrome, is a rare, multisystemic autosomal recessive disorder caused by pathogenic variants in the 15-hydroxyprostaglandin dehydrogenase (HPGD) or Solute ...
Rafaela Nicolau +7 more
doaj +2 more sources
Molecular cloning and characterization of the porcine prostaglandin transporter (
BMC Genetics, 2009 Background Because prostaglandins are involved in many (patho)physiological processes, SLCO2A1 was already characterized in several species in an attempt to unravel specific processes/deficiencies.
Cox Eric +5 more
doaj +2 more sources
Expression of the prostaglandin F synthase AKR1B1 and the prostaglandin transporter SLCO2A1 in human fetal membranes in relation to spontaneous term and preterm labour [PDF]
Frontiers in Physiology, 2014 Background: Human labour is a complex series of cellular and molecular events that occur at the materno-fetal and uterine levels. Many hypotheses have been proposed for the initiation of human labour, one hypothesis suggests that maturation of the fetus ...
Hana A Alzamil +3 more
doaj +2 more sources
Biological and prognostic insights into the prostaglandin D2 signaling axis in lung adenocarcinoma [PDF]
Frontiers in PharmacologyBackgroundTumor metabolism reprogramming is a hallmark of cancer, but metabolite-mediated intercellular communication remains poorly understood. To address this gap, we estimated and explored communication events exploring based on single‐cell RNA data ...
Qiang Liu +9 more
doaj +2 more sources
American Journal of Medical Genetics Part A, 2018 Pachydermoperiostosis (PDP), otherwise known as primary hypertrophic osteoarthropathy, is characterized by digital clubbing, pachydermia and subperiosteal new bone formation.
Puente Prieto, Jorge +11 more
core +6 more sources
Regulation of HPGD and SLCO2A1 in Colorectal Cancer Development [PDF]
, 2018 A wide range of lipid mediators are synthesised from Polyunsaturated Fatty Acids. These mediators regulate inflammation and many other processes in the human body, and perturbation of their signalling can contribute to the survival and proliferation of ...
Papagrigoriou, Spyridon
core +6 more sources
Author Correction: Structural basis for prostaglandin and drug transport via SLCO2A1 [PDF]
Nature CommunicationsChitra Joshi +10 more
doaj +2 more sources
Immunohistochemical differentiation between chronic enteropathy associated with gene and other inflammatory bowel diseases [PDF]
Intestinal Research, 2018 Background/AimsWe recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) as causative variants of chronic enteropathy associated with SLCO2A1 (CEAS).
Satoko Yamaguchi +9 more
doaj +1 more source