Results 21 to 30 of about 2,152 (193)

Multi-omics profiling of hepatic macromolecules in laying hens with difference feed intake: Mechanistic insights into antioxidant capacity modulation [PDF]

Poultry Science
Currently, the cost of poultry feed accounts for more than 70 % of the total cost of poultry production. Therefore, it is crucial to find appropriate strategies to reduce feed cost and improve feed efficiency in livestock genetic improvement programs ...
Zhouyang Gao, Yuchen Jie, Yuhui Qin, Xianli Liu, Chuanwei Zheng, Guoming Ma, Yan Wu, Songchuan Fu, Xiangrui Meng, Guiyun Xu   +9 more
doaj   +2 more sources

Acetaminophen as a possible safer alternative for reducing prostaglandin E2‐major urinary metabolites concentrations and alleviating joint pain in pachydermoperiostosis

JEADV Clinical Practice
JEADV Clinical Practice, Volume 4, Issue 1, Page 277-280, March 2025.
Tomoya Takegami, Takashi Nomura, Satoru Yonekura, Akiyoshi Senda, Kazue Yoshida, Atsuhito Seki, Kazuhiko Nakabayashi, Tadakazu Hisamatsu, Hiroki Kitamoto, Shuji Yamamoto, Yusuke Honzawa, Hiroshi Seno, Hironori Niizeki, Kenji Kabashima   +13 more
doaj   +2 more sources

Chronic Enteropathy Associated with <i>SLCO2A1</i> Gene. [PDF]

Inflamm Intest Dis
Background: Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare hereditary disorder characterized by multiple small intestinal ulcers, chronic anemia, and hypoproteinemia. Initially reported by Okabe et al. [J Jpn Soc Gastroenterol. 1968;65:1114–7] in 1968 as chronic nonspecific multiple ulcers of the small intestine, the condition was ...
Umeno J, Esaki M, Uchida K, Matsumoto T.
europepmc   +2 more sources

Clinical and Genetic Characteristics of Korean Patients Diagnosed with Chronic Enteropathy Associated with SLCO2A1 Gene: A KASID Multicenter Study

Gut and Liver, 2022
Background/Aims: Chronic enteropathy associated with SLCO2A1 gene (CEAS), an inherited disease characterized by nonspecific intestinal ulcers, has emerged in the Japanese population via loss-of-function mutations in the SLCO2A1 gene.
Hee Seung Hong, Jiwon Baek, Jae Chul Park, Ho-Su Lee, Dohoon Park, A-Ran Yoon, Soo Jung Park, Sung Noh Hong, Seong-Joon Koh, Chang Kyun Lee, Bo-In Lee, Sung Wook Hwang, Sang Hyoung Park, Seung-Jae Myung, Suk-Kyun Yang, Kyuyoung Song, Byong Duk Ye, on behalf of the IBD Research Group of the Korean Association for the Study of Intestinal Diseases   +17 more
doaj   +1 more source

Immunohistochemical differentiation between chronic enteropathy associated with gene and other inflammatory bowel diseases [PDF]

Intestinal Research, 2018
Background/AimsWe recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) as causative variants of chronic enteropathy associated with SLCO2A1 (CEAS).
Satoko Yamaguchi, Shunichi Yanai, Shotaro Nakamura, Keisuke Kawasaki, Makoto Eizuka, Noriyuki Uesugi, Tamotsu Sugai, Junji Umeno, Motohiro Esaki, Takayuki Matsumoto   +9 more
doaj   +1 more source

Crohn-like Disease Affecting Small Bowel Due to Monogenic SLCO2A1 Mutations: First Cases of Chronic Enteropathy Associated with SLCO2A1 Gene [CEAS] in France

Journal of Crohn's and Colitis, 2022
Abstract Introduction Multiple chronic ulcers of small intestine are mainly ascribed to Crohn’s disease. Among possible differential diagnoses are chronic ulcers of small bowel caused by abnormal activation of the prostaglandin pathway either in the archetypal but uncommon non-steroidal anti ...
Annick Hamon, Dominique Cazals-Hatem, Carmen Stefanescu, Mathieu Uzzan, Xavier Treton, Alain Sauvanet, Yves Panis, Marie Monsinjon, Fanny Bonvalet, Olivier Corcos, Emilie Azouguene, Nadine Cerf-Bensussan, Yoram Bouhnik, Fabienne Charbit-Henrion   +13 more
openaire   +2 more sources

HYPERTROPHIC OSTEOARTHROPATHY IN A PATIENT WITH HETEROZYGOUS MUTATION IN THE SLCO2A1 GENE: A CASE REPORT

Central Asian Journal of Medical Hypotheses and Ethics, 2023
Hypertrophic osteoarthropathy (HOA) is a condition characterized by aberrant skin and osseous tissue proliferation in the distal extremities. Mutations in the 15-hydroxyprostaglandin dehydrogenase gene (HPGD) and the soluble carrier organic anion carrier
Ilke Coskun Benlidayi, Kubra Tuncer, Tunay Sarpel   +2 more
doaj   +1 more source

A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy.

PLoS ONE, 2020
Chronic enteropathy associated with SLCO2A1 gene (CEAS) is caused by loss-of-function mutations in SLCO2A1, which encodes a prostaglandin (PG) transporter.
Keisuke Jimbo, Toshiaki Okuno, Ryuichi Ohgaki, Kou Nishikubo, Yuri Kitamura, Yumiko Sakurai, Lili Quan, Hiromichi Shoji, Yoshikatsu Kanai, Toshiaki Shimizu, Takehiko Yokomizo   +10 more
doaj   +1 more source

Contribution of Prostaglandin Transporter OATP2A1/SLCO2A1 to Placenta-to-Maternal Hormone Signaling and Labor Induction

iScience, 2020
Summary: We evaluated the contribution of organic anion transporting polypeptide 2A1 (OATP2A1/SLCO2A1), a high-affinity carrier for prostaglandins (PGs), to the parturition process. At gestational day (GD) 15.5, OATP2A1 is co-localized with 15-hydroxy-PG
Mai Inagaki, Tomohiro Nishimura, Takeo Nakanishi, Hiroaki Shimada, Saki Noguchi, Shin-ichi Akanuma, Masanori Tachikawa, Ken-ichi Hosoya, Ikumi Tamai, Emi Nakashima, Masatoshi Tomi   +10 more
doaj   +1 more source

The ATP-Releasing Maxi-Cl Channel: Its Identity, Molecular Partners, and Physiological/Pathophysiological Implications

Life, 2021
The Maxi-Cl phenotype accounts for the majority (app. 60%) of reports on the large-conductance maxi-anion channels (MACs) and has been detected in almost every type of cell, including placenta, endothelium, lymphocyte, cardiac myocyte, neuron, and glial ...
Ravshan Z. Sabirov, Md. Rafiqul Islam, Toshiaki Okada, Petr G. Merzlyak, Ranokhon S. Kurbannazarova, Nargiza A. Tsiferova, Yasunobu Okada   +6 more
doaj   +1 more source