Results 11 to 20 of about 2,152 (193)

Novel SLCO2A1 mutations cause gender-differentiated pachydermoperiostosis [PDF]

Endocrine Connections, 2018
Primary hypertrophic osteoarthropathy (PHO) is a rare familial disorder with reduced penetrance for females. The genetic mutations associated with PHO have been identified in HPGD and SLCO2A1, which involved in prostaglandin E2 metabolism.
Lijuan Yuan, Xihui Chen, Ziyu Liu, Dan Wu, Jianguo Lu, Guoqiang Bao, Sijia Zhang, Lifeng Wang, Yuanming Wu   +8 more
doaj   +13 more sources

Molecular cloning and characterization of the porcine prostaglandin transporter (SLCO2A1): evaluation of its role in F4 mediated neonatal diarrhoea [PDF]

BMC Genetics, 2009
Background Because prostaglandins are involved in many (patho)physiological processes, SLCO2A1 was already characterized in several species in an attempt to unravel specific processes/deficiencies.
Cox Eric, Van Zeveren Alex, Erkens Tim, Melkebeek Vesna, Van Poucke Mario, Peelman Luc J   +5 more
doaj   +5 more sources

Distinction between Chronic Enteropathy Associated with the SLCO2A1 Gene and Crohn’s Disease

Gut and Liver, 2019
Background/Aims We recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) as causative variants of chronic nonspecific multiple ulcers of the small intestine (chronic enteropathy ...
Shunichi Yanai, Satoko Yamaguchi, Shotaro Nakamura, Keisuke Kawasaki, Yosuke Toya, Noriyuki Yamada, Makoto Eizuka, Noriyuki Uesugi, Junji Umeno, Motohiro Esaki, Eiko Okimoto, Shunji Ishihara, Tamotsu Sugai, Takayuki Matsumoto   +13 more
doaj   +4 more sources

An Exome-Wide Sequencing Study of the GOLDN Cohort Reveals Novel Associations of Coding Variants and Fasting Plasma Lipids [PDF]

Frontiers in Genetics, 2019
Background: Associations of both common and rare genetic variants with fasting blood lipids have been extensively studied. However, most of the rare coding variants associated with lipids are population-specific, and exploration of genetic data from ...
Xin Geng, Xin Geng, Marguerite R. Irvin, Bertha Hidalgo, Stella Aslibekyan, Vinodh Srinivasasainagendra, Ping An, Alexis C. Frazier-Wood, Hemant K. Tiwari, Tushar Dave, Kathleen Ryan, Jose M. Ordovas, Jose M. Ordovas, Jose M. Ordovas, Robert J. Straka, Mary F. Feitosa, Paul N. Hopkins, Ingrid Borecki, Michael A. Province, Braxton D. Mitchell, Donna K. Arnett, Degui Zhi, Degui Zhi   +22 more
doaj   +3 more sources

A Hereditary Enteropathy Caused by Mutations in the SLCO2A1 Gene, Encoding a Prostaglandin Transporter. [PDF]

PLoS Genetics, 2015
Previously, we proposed a rare autosomal recessive inherited enteropathy characterized by persistent blood and protein loss from the small intestine as chronic nonspecific multiple ulcers of the small intestine (CNSU).
Junji Umeno, Tadakazu Hisamatsu, Motohiro Esaki, Atsushi Hirano, Naoya Kubokura, Kouichi Asano, Shuji Kochi, Shunichi Yanai, Yuta Fuyuno, Katsuyoshi Shimamura, Naoki Hosoe, Haruhiko Ogata, Takashi Watanabe, Kunihiko Aoyagi, Hidehisa Ooi, Kenji Watanabe, Shigeyoshi Yasukawa, Fumihito Hirai, Toshiyuki Matsui, Mitsuo Iida, Tsuneyoshi Yao, Toshifumi Hibi, Kenjiro Kosaki, Takanori Kanai, Takanari Kitazono, Takayuki Matsumoto   +25 more
doaj   +4 more sources

Meta-Analysis-Assisted Detection of Gravity-Sensitive Genes in Human Vascular Endothelial Cells [PDF]

Frontiers in Cell and Developmental Biology, 2021
Gravity affects the function and maintenance of organs, such as bones, muscles, and the heart. Several studies have used DNA microarrays to identify genes with altered expressions in response to gravity.
Yin Liang, Mengxue Wang, Yun Liu, Chen Wang, Ken Takahashi, Keiji Naruse   +5 more
doaj   +4 more sources

Up-regulation of cytosolic prostaglandin E synthase in fetal-membrane and amniotic prostaglandin E2 accumulation in labor. [PDF]

PLoS ONE, 2021
Prostaglandin E2 (PGE2) is known to have important roles in labor, but the detailed mechanism underlying the spontaneous human labor remains unknown.
Nanase Takahashi, Toshiaki Okuno, Hiroki Fujii, Shintaro Makino, Masaya Takahashi, Mai Ohba, Kazuko Saeki, Atsuo Itakura, Satoru Takeda, Takehiko Yokomizo   +9 more
doaj   +2 more sources

Integration of Digital Denture Technology in the Prosthodontic Management of Pediatric Osteopetrosis: A Case Report. [PDF]

Case Rep Dent
Osteopetrosis is a rare hereditary disorder characterized by impaired osteoclastic bone resorption, resulting in generalized skeletal sclerosis, increased bone fragility, and a heightened risk of complications such as osteomyelitis. Prosthodontic rehabilitation in pediatric patients is particularly challenging due to ongoing craniofacial growth ...
Niakou A, Kamalakidis S, Stratos A, Arapostathis K, Kotsiomiti E.   +4 more
europepmc   +2 more sources

Biological and prognostic insights into the prostaglandin D2 signaling axis in lung adenocarcinoma [PDF]

Frontiers in Pharmacology
BackgroundTumor metabolism reprogramming is a hallmark of cancer, but metabolite-mediated intercellular communication remains poorly understood. To address this gap, we estimated and explored communication events exploring based on single‐cell RNA data ...
Qiang Liu, Huiguo Chen, Dongfang Tang, Huibiao Zhang, Shaogeng Chen, Yiran Meng, Boying Zheng, Fei Liu, Jing Zhou, Wen Zhang   +9 more
doaj   +2 more sources

Age-related variations in prostaglandin E-major urinary metabolite values in Japanese children. [PDF]

Pediatr Int
Abstract Background Prostaglandin E‐major urinary metabolite (PGE‐MUM) is an emerging noninvasive biomarker used to evaluate clinical and endoscopic activity in patients with inflammatory bowel disease. Previous studies have shown that PGE‐MUM values correlate with colonic inflammation in pediatric ulcerative colitis; however, reference values for ...
Maeyama T, Takashiba A, Hata A, Hizuka K, Saura R, Etani Y, Hagiwara SI.   +6 more
europepmc   +2 more sources