Results 91 to 100 of about 1,942 (174)

Fusobacterium nucleatum Promotes the Growth and Metastasis of Colorectal Cancer by Activating E‐Cadherin/Krüppel‐Like Factor 4/Integrin α5 Signaling in a Calcium‐Dependent Manner

MedComm, Volume 6, Issue 3, March 2025.
Our findings reveal that Fusobacterium nucleatum increases intracellular Ca2+ concentration, which promotes interaction between E‐cadherin and KLF4, resulting in KLF4 phosphorylation and translocation in the nucleus. The phosphorylated KLF4 induces ITGA5 transcription and activated FAK/PI3K/Akt1 signaling, finally promoting the growth, invasion, and ...
Xuebing Yan, Xiao Qu, Jiaxin Wang, Ling Lu, Wenjuan Wu, Jingxian Mao, Donglin Li, Ying Wang, Qing Wei, Jianqiang Liu   +9 more
wiley   +1 more source

Effects of Maternal Diabetes and Diet on Gene Expression in the Murine Placenta [PDF]

, 2022
Adverse exposures during pregnancy have been shown to contribute to susceptibility for chronic diseases in offspring. Maternal diabetes during pregnancy is associated with higher risk of pregnancy complications, structural birth defects, and ...
Kappen, Claudia, Kruger, Claudia, Michael Salbaum, J.   +2 more
core   +1 more source

Histopathological study of the localization/distribution of Fusobacterium nucleatum in esophageal cancer

Pathology International, Volume 75, Issue 2, Page 82-91, February 2025.
We visualized F. nucleatum using FISH and identified different distribution patterns of F. nucleatum, highlighting the spot density of its presence in tumor tissues. F. nucleatum was identified more frequently in esophageal cancer tissues than in the normal epithelium. As tumor progression advanced, the area occupied by F.
Iku Sasaki‐Higashimoto, Fumiyoshi Fujishima, Hirotaka Ishida, Yusuke Taniyama, Yohei Ozawa, Tomohiro Nakamura, Naoki Nakaya, Chiaki Sato, Hiroshi Okamoto, Junichi Tsunokake, Atsushi Kunimitsu, Takeru Mozumi, Takashi Kamei, Takashi Suzuki   +13 more
wiley   +1 more source

A Case Report of Pachydermoperiostosis by Multidisciplinary Diagnosis and Treatment

罕见病研究
A 20-year-old male patient presented to the Department of Dermatology of Peking Union Medical College Hospital with complaints of an 8-year history of facial scarring, swelling of the lower limbs, and a 4-year history of scalp thickening.
ZHANG Jie, ZHANG Yan, HUO Li, LYU Ke, WANG Tao, XIA Ze'nan, LONG Xiao, XU Kexin, WU Nan, YANG Bo, XIA Weibo, HU Rongrong, CHEN Limeng, LI Ji, HONG Xia, ZHANG Yan, ZUO Yagang   +16 more
doaj   +1 more source

Induced Pluripotent Stem Cell‐Derived Parathyroid Organoids Resemble Parathyroid Morphology and Function

Advanced Science, Volume 11, Issue 43, November 20, 2024.
iPSC‐derived parathyroid organoids express PTH‐related markers at the protein and gene levels. The transplantation of parathyroid organoids into parathyroidectomized rats shows their functional activity and tissue integration capability. iPSC‐derived parathyroid organoids successfully release PTH both in vitro and in vivo.
Selinay Şenkal‐Turhan, Ezgi Bulut‐Okumuş, Muhterem Aydın, Neşe Başak Türkmen, Aslı Taşlıdere, Fikrettin Şahin, Şahin Yılmaz, Pınar Akkuş Süt, Ayşegül Doğan   +8 more
wiley   +1 more source

Alterations in the expression of pituitary solute carrier (SLCs) families, ubiquitin-protease system, and ATP pump genes of high and low weight broilers using a microarray database analysis [PDF]

Journal of Epigenetics
Selecting for juvenile body weight over the long term from a shared original population resulted in the creation of two distinct chicken lines: the low-weight selected line (LWS) and the high-weight selected line (HWS).
Yadollah Badakhshan, Zahrai Roudbari, Manuchehr Yousefi   +2 more
doaj   +1 more source

Single‐cell RNA‐seq in diabetic foot ulcer wound healing

Wound Repair and Regeneration, Volume 32, Issue 6, Page 880-889, November/December 2024.
Abstract Diabetic foot ulcer (DFU) is a chronic and serious complication of diabetes mellitus. It is mainly caused by hyperglycaemia, diabetic peripheral vasculopathy and diabetic peripheral neuropathy. These conditions result in ulceration of foot tissues and chronic wounds.
Yan Dong, Mengting Wang, Qianqian Wang, Xiaoliang Cao, Peng Chen, Zhenhua Gong   +5 more
wiley   +1 more source

Evaluation of a Chemiluminescent Enzyme Immunoassay for the Detection of Prostaglandin E‐Major Urinary Metabolite (PGE‐MUM)

Journal of Clinical Laboratory Analysis, Volume 38, Issue 19-20, October 2024.
We developed a chemiluminescent enzyme immunoassay (CLEIA), which can detect prostaglandin E‐major urinary metabolite (PGE‐MUM) with automated procedure in ~30 min. Here, we evaluated its analytical performance. This assay can precisely detect PGE‐MUM with good reproducibility and showed a good correlation with preceding radioimmunoassay (RIA ...
Jun Takagi, Kazushige Moriyama, Seiji Arihiro, Tomohiro Kato, Toshiyuki Sakurai, Masayuki Saruta, Mie Wakabayashi, Hidekazu Nasu, Noriko Katagiri, Shintaro Yagi   +9 more
wiley   +1 more source

A Complete Form of Pachydermoperiostosis Accompanied by a Pituitary Microadenoma

Clinical, Cosmetic and Investigational Dermatology, 2023
Yan Jing Chen, Li Li Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Li Li, Department of dermatology and venereology, West China Hospital, Sichuan University,
Chen YJ, Li L
doaj  

Fusobacterium nucleatum, immune responses, and metastatic organ diversity in colorectal cancer liver metastasis

Cancer Science, Volume 115, Issue 10, Page 3248-3255, October 2024.
In this retrospective cohort study of 218 patients with colorectal cancer (CRC) liver metastasis, Fusobacterium nucleatum was detected in liver metastasis tissues in 42% of cases and was associated with increased serum C‐reactive protein levels, reduced numbers of CD8+ cells and FOXP3+ cells in tumor tissues, and an increased number of metastatic ...
Yasuyuki Shigematsu, Rumiko Saito, Gulanbar Amori, Hiroaki Kanda, Yu Takahashi, Kengo Takeuchi, Shunji Takahashi, Kentaro Inamura   +7 more
wiley   +1 more source