Results 71 to 80 of about 2,514,688 (144)

System genetic analysis of intestinal cancer and periodontitis development as influenced by aging and diabesity using Collaborative Cross mice

Animal Models and Experimental Medicine, Volume 8, Issue 4, Page 758-770, April 2025.
It is increasingly recognized that young, chow‐fed inbred mice poorly model the complexity of human carcinogenesis in multiple respects. In humans, age and adiposity are the major risk factors for the majority of malignancies. Although the development of genetically engineered mouse models (GEMM) of cancer has recapitulated many aspects of human cancer,
Iqbal M. Lone, Osayd Zohud, Kareem Midlej, Charles Brenner, Fuad A. Iraqi   +4 more
wiley   +1 more source

A Narrative Review on the Effect of Valproic Acid on the Placenta

Birth Defects Research, Volume 117, Issue 4, April 2025.
ABSTRACT Background Valproic acid (VPA) is an antiepileptic and mood‐stabilizing drug with well‐established teratogenic risks when taken during pregnancy. While its harmful effects on fetal development are well known, less attention has been given to its impact on placental development and function, despite the placenta's critical role in pregnancy ...
Lauren T. L. Brown, Delaine Pereira, Louise M. Winn   +2 more
wiley   +1 more source

Fusobacterium nucleatum Promotes the Growth and Metastasis of Colorectal Cancer by Activating E‐Cadherin/Krüppel‐Like Factor 4/Integrin α5 Signaling in a Calcium‐Dependent Manner

MedComm, Volume 6, Issue 3, March 2025.
Our findings reveal that Fusobacterium nucleatum increases intracellular Ca2+ concentration, which promotes interaction between E‐cadherin and KLF4, resulting in KLF4 phosphorylation and translocation in the nucleus. The phosphorylated KLF4 induces ITGA5 transcription and activated FAK/PI3K/Akt1 signaling, finally promoting the growth, invasion, and ...
Xuebing Yan, Xiao Qu, Jiaxin Wang, Ling Lu, Wenjuan Wu, Jingxian Mao, Donglin Li, Ying Wang, Qing Wei, Jianqiang Liu   +9 more
wiley   +1 more source

Histopathological study of the localization/distribution of Fusobacterium nucleatum in esophageal cancer

Pathology International, Volume 75, Issue 2, Page 82-91, February 2025.
We visualized F. nucleatum using FISH and identified different distribution patterns of F. nucleatum, highlighting the spot density of its presence in tumor tissues. F. nucleatum was identified more frequently in esophageal cancer tissues than in the normal epithelium. As tumor progression advanced, the area occupied by F.
Iku Sasaki‐Higashimoto, Fumiyoshi Fujishima, Hirotaka Ishida, Yusuke Taniyama, Yohei Ozawa, Tomohiro Nakamura, Naoki Nakaya, Chiaki Sato, Hiroshi Okamoto, Junichi Tsunokake, Atsushi Kunimitsu, Takeru Mozumi, Takashi Kamei, Takashi Suzuki   +13 more
wiley   +1 more source

A Case Report of Pachydermoperiostosis by Multidisciplinary Diagnosis and Treatment

罕见病研究
A 20-year-old male patient presented to the Department of Dermatology of Peking Union Medical College Hospital with complaints of an 8-year history of facial scarring, swelling of the lower limbs, and a 4-year history of scalp thickening.
ZHANG Jie, ZHANG Yan, HUO Li, LYU Ke, WANG Tao, XIA Ze'nan, LONG Xiao, XU Kexin, WU Nan, YANG Bo, XIA Weibo, HU Rongrong, CHEN Limeng, LI Ji, HONG Xia, ZHANG Yan, ZUO Yagang   +16 more
doaj   +1 more source

Induced Pluripotent Stem Cell‐Derived Parathyroid Organoids Resemble Parathyroid Morphology and Function

Advanced Science, Volume 11, Issue 43, November 20, 2024.
iPSC‐derived parathyroid organoids express PTH‐related markers at the protein and gene levels. The transplantation of parathyroid organoids into parathyroidectomized rats shows their functional activity and tissue integration capability. iPSC‐derived parathyroid organoids successfully release PTH both in vitro and in vivo.
Selinay Şenkal‐Turhan, Ezgi Bulut‐Okumuş, Muhterem Aydın, Neşe Başak Türkmen, Aslı Taşlıdere, Fikrettin Şahin, Şahin Yılmaz, Pınar Akkuş Süt, Ayşegül Doğan   +8 more
wiley   +1 more source

Alterations in the expression of pituitary solute carrier (SLCs) families, ubiquitin-protease system, and ATP pump genes of high and low weight broilers using a microarray database analysis [PDF]

Journal of Epigenetics
Selecting for juvenile body weight over the long term from a shared original population resulted in the creation of two distinct chicken lines: the low-weight selected line (LWS) and the high-weight selected line (HWS).
Yadollah Badakhshan, Zahrai Roudbari, Manuchehr Yousefi   +2 more
doaj   +1 more source

Mutations in the prostaglandin transporter encoding gene SLCO2A1 Cause primary hypertrophic osteoarthropathy and isolated digital clubbing

, 2012
Digital clubbing is usually secondary to different acquired diseases. Primary hypertrophic osteoarthropathy (PHO) is a rare hereditary disorder with variable digital clubbing as the most prominent feature, subperiosteal new bone formation, and ...
Tueysuez, Beyhan, SPECKER, Christof, BROUWERS, AD, HORN, Denise, SEIFERT, Wenke, KUEHNISCH, Jirko   +5 more
core   +1 more source

A Complete Form of Pachydermoperiostosis Accompanied by a Pituitary Microadenoma

Clinical, Cosmetic and Investigational Dermatology, 2023
Yan Jing Chen, Li Li Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Li Li, Department of dermatology and venereology, West China Hospital, Sichuan University,
Chen YJ, Li L
doaj  

Exome Sequencing Identifies SLCO2A1 Mutations as a Cause of Primary Hypertrophic Osteoarthropathy [PDF]

, 2012
By using whole-exome sequencing, we identified a homozygous guanine-to-adenine transition at the invariant −1 position of the acceptor site of intron 1 (c.97−1G>A) in solute carrier organic anion transporter family member 2A1 (SLCO2A1), which encodes a ...
Yue, Hua, Hu, Weiwei, Hu, Yunqiu, Liu, Yujuan, Wang, Chun, Zhang, Hao, Xia, Weibo, Zhang, Zhenlin, Ke, Yaohua, Gu, Jiemei, Zhang, Zeng, Fu, Wenzhen, He, Jinwei, Li, Miao   +13 more
core   +1 more source