Results 81 to 90 of about 2,514,688 (144)

The first case of primary hypertrophic osteoarthropathy with soft tissue giant tumors caused by HPGD loss-of-function mutation

Endocrine Connections, 2019
Background: Primary hypertrophic osteoarthropathy (PHO) is a rare genetic multi-organic disease characterized by digital clubbing, periostosis and pachydermia. Two genes, HPGD and SLCO2A1, which encodes 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and
Qianqian Pang, Yuping Xu, Xuan Qi, Yan Jiang, Ou Wang, Mei Li, Xiaoping Xing, Ling Qin, Weibo Xia   +8 more
doaj   +1 more source

BLM-induced pulmonary fibrosis in WT and Slco2a1-/- mice.

, 2015
(A) Slco2a1 protein expression was confirmed by Western blot analysis in lung homogenates prepared from WT and Slco2a1-/- mice. (B) Slco2a1 protein expression was examined by Western blot analysis in lung homogenates from PBS- and BLM-treated WT mice ...
Shin-ichi Akanuma (331229), Tomohiko Wakayama (29594), Ikumi Tamai (333356), Yuka Uetoko (731749), Ken-ichi Hosoya (331230), Takeo Nakanishi (333351), Reo Mimura (731748), Yoshitaka Hasegawa (731747), Hisakazu Komori (731750)   +8 more
core   +1 more source

A pediatric patient with chronic enteropathy associated with SLCO2A1 who underwent multimodal treatment including several surgeries: a case report

Frontiers in Surgery
IntroductionChronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare protein-losing enteropathy primarily recognized in Asia. Its uncommon nature and limited research usually complicate diagnosis and treatment. This review examines the course of
Yoojin Jung, Jaehee Chung, Inhyuk Yoo
doaj   +1 more source

Acetaminophen as a possible safer alternative for reducing prostaglandin E2‐major urinary metabolites concentrations and alleviating joint pain in pachydermoperiostosis

JEADV Clinical Practice, Volume 4, Issue 1, Page 277-280, March 2025.
Tomoya Takegami, Takashi Nomura, Satoru Yonekura, Akiyoshi Senda, Kazue Yoshida, Atsuhito Seki, Kazuhiko Nakabayashi, Tadakazu Hisamatsu, Hiroki Kitamoto, Shuji Yamamoto, Yusuke Honzawa, Hiroshi Seno, Hironori Niizeki, Kenji Kabashima   +13 more
wiley   +1 more source

Biological and prognostic insights into the prostaglandin D2 signaling axis in lung adenocarcinoma

Frontiers in Pharmacology
BackgroundTumor metabolism reprogramming is a hallmark of cancer, but metabolite-mediated intercellular communication remains poorly understood. To address this gap, we estimated and explored communication events exploring based on single‐cell RNA data ...
Qiang Liu, Huiguo Chen, Dongfang Tang, Huibiao Zhang, Shaogeng Chen, Yiran Meng, Boying Zheng, Fei Liu, Jing Zhou, Wen Zhang   +9 more
doaj   +1 more source

Dual Functions of SLCO2A1 as Maxi-Cl Channel and PG Transporter

Solute carrier organic anion transporter family member 2A1 (SLCO2A1) is known to be a molecule responsible for prostaglandin transporter (PGT). Recently, SLCO2A1 was, in addition, identified as the core (pore-forming) molecule of large-conductance maxi ...
Yasunobu Okada, Ravshan Z Sabirov, Petr G Merzlyak, Takeo Nakanishi   +3 more
core   +1 more source

Supplementary Material for: Primary Hypertrophic Osteoarthropathy Mimicking Juvenile Idiopathic Arthritis: A Novel SLCO2A1 Mutation and Imaging Findings

, 2019
Primary hypertrophic osteoarthropathy (PHO), also known as pachydermoperiostosis, is a rare, multisystemic, autosomal recessive condition typically presenting with digital clubbing, osteoarthropathy, and various skin manifestations.
Karabulut H.G. (6851148), Torgutalp M (6851143), Durmaz C.D (6851145), Seifert W. (6851149), Turgay M. (6851153), Akkaya Z. (6851152), Horn D. (6851151)   +6 more
core   +1 more source

Inflammatory profiling and immune cell infiltration in dysthyroid optic neuropathy: insights from bulk RNA sequencing

Frontiers in Immunology
BackgroundDysthyroid optic neuropathy (DON), the most severe complication of thyroid eye disease (TED), has unclear mechanisms and unsatisfactory treatment outcomes.
Qintao Ma, Yuanping Hai, Yongbo Duan, Genfeng Yu, Cheng Song, ShengAi Huang, Anqi Huang, Yan Zhu, Yongzhi Shen, Zimeng Huang, Xiao Wang, Lan Liu, Thomas Efferth, Huiyu Guo, Yi Wang, Yi Wang, Jie Shen   +16 more
doaj   +1 more source

Supplementary Tables 1 - 2 from Inactivating Mutation in the Prostaglandin Transporter Gene, SLCO2A1, Associated with Familial Digital Clubbing, Colon Neoplasia, and NSAID Resistance

, 2014
PDF file - 28KB, Table S1: PCR primer sequences for amplification of SLCO2A1 (c.584C>A, p.104G>STOP) mutant position in germline DNA. Table S2: PCR primer sequences for amplification of SLCO2A1 coding sequence in formalin-fixed paraffin-embedded colon ...
Stephen P. Fink (14890703), Courtney G. Montgomery (8544045), Kishore Guda (169995), Lakshmeswari Ravi (3588482), Neil Molyneaux (15094472), Georgia L. Wiesner (14898747), Sanford D. Markowitz (9508648), Susan M. Lewis (15094475), Shulin Zhang (154810), Joseph Willis (459937), Ginger L. Milne (8081348), Andrew J. Dannenberg (1265112)   +11 more
core   +1 more source

Identification of macrophage differentiation related genes and subtypes linking atherosclerosis plaque processing and metabolic syndrome via integrated bulk and single-cell sequence analysis

Heliyon
Metabolic syndrome(MS) is a separate risk factor for the advancement of atherosclerosis(AS) plaque but mechanism behind this remains unclear. There may be a significant role for the immune system in this process.
Da-Sheng Ning, Zi-Qing Zhou, Shu-Heng Zhou, Ji-Mei Chen   +3 more
doaj   +1 more source