Results 61 to 70 of about 2,514,688 (144)

Primary Hypertrophic Osteoarthropathy Mimicking Juvenile Idiopathic Arthritis: A Novel SLCO2A1 Mutation and Imaging Findings [PDF]

, 2019
Primary hypertrophic osteoarthropathy (PHO), also known as pachydermoperiostosis, is a rare, multisystemic, autosomal recessive condition typically presenting with digital clubbing, osteoarthropathy, and various skin manifestations.
Durmaz, Ceren D., Seifert, Wenke, Horn, Denise, Torgutalp, Murat, Karabulut, Halil G., Akkaya, Zehra, Turgay, Murat   +6 more
core   +1 more source

Differential Expression Patterns of SLCO Solute Carriers in Human Breast Cancer Cell Lines and Tumour Samples

Journal of Cellular and Molecular Medicine, Volume 29, Issue 17, September 2025.
ABSTRACT The cellular uptake of nutrients essential for cell growth and survival is facilitated by solute carrier (SLC) transporters. Members of the SLCO subfamily of SLCs mediate the uptake of substrates relevant to breast cancer (BC), including steroid hormones and anticancer drugs.
Rachel Telfer‐Sutherland, Louise Page, Annette Meeson, Simon Lowes   +3 more
wiley   +1 more source

Monogenic SLCO2A1 gene mutation presenting as early onset inflammatory bowel disease-A report of rare case with review of literature

Indian Journal of Pathology and Microbiology
Chronic enteropathy associated with the SLCO2A1 gene (CEAS) is a rare, autosomal recessive disorder characterized by multiple chronic ulcerative and structuring lesions in the small intestine, primarily affecting the ileum.
Mukund Namdev Sable, M. Shameema Farween, Susama Patra, Saswati Kar, Subash Chandra Samal   +4 more
doaj   +1 more source

Safety and efficacy of cyclooxygenase-2 inhibition for treatment of primary hypertrophic osteoarthropathy: A single-arm intervention trial

Journal of Orthopaedic Translation, 2019
Background: Primary hypertrophic osteoarthropathy (PHO) is a rare disease involving joint, bone and skin. Two underlying genes responsible for this disease—hydroxyprostaglandin dehydrogenase (HPGD) and solute carrier organic anion transporter family ...
Lu Yuan, Ruo-xi Liao, Yuan-yuan Lin, Yan Jiang, Ou Wang, Mei Li, Xiao-ping Xing, Qian-qian Pang, Evelyn Hsieh, Wei-bo Xia   +9 more
doaj   +1 more source

Imaging Techniques and Differential Diagnosis for Inflammatory Bowel Disease

Journal of the Korean Society of Radiology, 2023
The two main types of inflammatory bowel disease (IBD) are Crohn’s disease and ulcerative colitis. Currently, when IBD is suspected, CT enterography is widely used as an initial imaging test because it can evaluate both the bowel wall and the outside ...
Kyoung Doo Song
doaj   +1 more source

Primary Hypertrophic Osteoarthropathy (Pachydermoperiostosis): Two Brothers Misdiagnosed As Inflammatory Arthritis

Trends in Urology &Men's Health, Volume 16, Issue 4, August 2025.
ABSTRACT Primary hypertrophic osteoarthropathy (Pachydermoperiostosis) is a rare, inherited genetic disorder of the skeleton and the skin, characterised by clubbing of the fingers, thickening of the skin especially of the face and forehead (pachydermia) and periostosis. Patients often present with pain and swelling of the knees and ankles.
Ahmed AbdulBari, Farooq Fouad, Sarah Mushtaq, Ali Jawad   +3 more
wiley   +1 more source

Enteroscopic Balloon Dilation in Small Bowel Stricturing Crohn’s Disease: Long‐Term Outcomes and Risk Factors for Surgery in a Single‐Center Prospective Observational Study

United European Gastroenterology Journal, Volume 13, Issue 6, Page 958-970, July 2025.
ABSTRACT Background and Aims The long‐term outcomes of enteroscopic balloon dilation for small bowel strictures in patients with Crohn’s disease are not well understood. Although Crohn’s strictures can be classified into web‐like, ulcerated, and spindle‐shaped strictures based on endoscopic findings, the outcomes of enteroscopic balloon dilation ...
Sung Noh Hong, Ji Eun Kim, Eun Ran Kim, Dong Kyung Chang, Young‐Ho Kim   +4 more
wiley   +1 more source

A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer

, 2017
Prostaglandin E2 (PGE2) is associated with proliferation and angiogenesis in colorectal tumours. The role of prostaglandin transporter OATP2A1/SLCO2A1 in colon cancer tumorogenesis is unknown.
Hiroaki Shimada, Ikumi Tamai, Shunsuke Kamo, Rika Aotani, Yasuhiro Ohno, Hiroko Oshima, Shio Maruyama, Masanobu Oshima, John D. Schuetz, Takeo Nakanishi   +9 more
core   +1 more source

A Case Study of a Female Infant With Primary Hypertrophic Osteoarthropathy Demonstrates That Early Initiation of Celecoxib Slows but Does Not Prevent Symptom Progression

American Journal of Medical Genetics Part A, Volume 197, Issue 5, May 2025.
ABSTRACT Primary Hypertrophic Osteoarthropathy (PHOAR1) is characterized by autosomal recessive loss of function variants in 15‐hydroxyprostaglandin dehydrogenase (HPGD) leading to digital clubbing, periostosis, pachydermia, and severe hyperhidrosis. HPGD catalyzes the first step of prostaglandin E2 (PGE2) degradation.
Kara Zehr, Morgan Buckley, Joshua W. Owens, Tomas Vanagunas, Patricia Vega Fernandez, Robert J. Hopkin, Amelle Shillington   +6 more
wiley   +1 more source

Association of the CCR5 gene with juvenile idiopathic arthritis [PDF]

, 2010
The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction.
Martin, P., BSPAR Study Group, Barton, A., UKRAG Consortium, Worthington, J., Gardner-Medwin, J. [CAPS and BSPAR Study Groups], Thomson, W., W Thomson, Flynn, E., A Hinks, E Flynn, J Packham, Packham, J., Hinks, A., S Eyre, J Worthington, Eyre, S.; id_orcid, Eyre, S., Barton, A.; id_orcid, P Martin, Childhood Arthritis Prospective Study (CAPS), Martin, P.; id_orcid, A Barton   +22 more
core   +1 more source