Results 11 to 20 of about 1,942 (174)

Immunohistochemical differentiation between chronic enteropathy associated with gene and other inflammatory bowel diseases [PDF]

Intestinal Research, 2018
Background/AimsWe recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) as causative variants of chronic enteropathy associated with SLCO2A1 (CEAS).
Satoko Yamaguchi, Shunichi Yanai, Shotaro Nakamura, Keisuke Kawasaki, Makoto Eizuka, Noriyuki Uesugi, Tamotsu Sugai, Junji Umeno, Motohiro Esaki, Takayuki Matsumoto   +9 more
doaj   +4 more sources

HYPERTROPHIC OSTEOARTHROPATHY IN A PATIENT WITH HETEROZYGOUS MUTATION IN THE SLCO2A1 GENE: A CASE REPORT [PDF]

Central Asian Journal of Medical Hypotheses and Ethics, 2023
Hypertrophic osteoarthropathy (HOA) is a condition characterized by aberrant skin and osseous tissue proliferation in the distal extremities. Mutations in the 15-hydroxyprostaglandin dehydrogenase gene (HPGD) and the soluble carrier organic anion carrier
Ilke Coskun Benlidayi, Kubra Tuncer, Tunay Sarpel   +2 more
doaj   +4 more sources

SLCO2A1 gene is the causal gene for both primary hypertrophic osteoarthropathy and hereditary chronic enteropathy [PDF]

Journal of Orthopaedic Translation, 2021
Junji Umeno, Takayuki Matsumoto, Yuta Fuyuno, Motohiro Esaki, Takehiro Torisu   +4 more
doaj   +4 more sources

Slco2a1 deficiency exacerbates experimental colitis via inflammasome activation in macrophages: a possible mechanism of chronic enteropathy associated with SLCO2A1 gene. [PDF]

Sci Rep, 2020
AbstractLoss-of-function mutations in the solute carrier organic anion transporter family, member 2a1 gene (SLCO2A1), which encodes a prostaglandin (PG) transporter, have been identified as causes of chronic nonspecific multiple ulcers in the small intestine; however, the underlying mechanisms have not been revealed.
Nakata R, Nakamura Y, Hosomi S, Okuda H, Nishida Y, Sugita N, Itani S, Nadatani Y, Otani K, Tanaka F, Kamata N, Taira K, Nagami Y, Tanigawa T, Watanabe T, Yamagami H, Nakanishi T, Fujiwara Y.   +17 more
europepmc   +6 more sources

Estimated Prevalence of Cronkhite-Canada Syndrome, Chronic Enteropathy Associated With SLCO2A1 Gene, and Intestinal Behçet’s Disease in Japan in 2017: A Nationwide Survey [PDF]

Journal of Epidemiology, 2021
Background: Cronkhite-Canada syndrome (CCS), chronic enteropathy associated with SLCO2A1 gene (CEAS), and intestinal Behçet’s disease (BD) are classified as intractable intestinal disorders in Japan.
Mari S. Oba, Yoshitaka Murakami, Yuji Nishiwaki, Keiko Asakura, Satoko Ohfuji, Wakaba Fukushima, Yosikazu Nakamura, Yasuo Suzuki   +7 more
doaj   +2 more sources

Characteristics of chronic enteropathy associated with SLCO2A1 gene (CEAS) in children, a unique type of monogenic very early-onset inflammatory bowel disease [PDF]

BMC Pediatrics
Background  Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a unique type of inflammatory bowel disease. CEAS is monogenic disease and is thought to develop from childhood, but studies on pediatric CEAS are scarce.
Jin Gyu Lim, Jae Sung Ko, Jung Min Ko, Hyun Young Kim, Man Jin Kim, Moon Woo Seong, Young Hun Choi, Gyeong Hoon Kang, Jaemoon Koh, Jin Soo Moon   +9 more
doaj   +2 more sources

Structure and transport mechanism of the human prostaglandin transporter SLCO2A1 [PDF]

Nature Communications
SLCO2A1 is a member of the organic anion transporting polypeptide (OATP) family, which preferentially transports prostaglandins (PGs) into cells and plays a vital role in regulating PGs inactivation and distribution.
Zhanyi Xia, Guangyuan Lu, Di Wu, Jun Zhao, Bowen Zhang, Haoran Xu, Yingying Du, Daohua Jiang   +7 more
doaj   +2 more sources

Differential Expression Patterns of SLCO Solute Carriers in Human Breast Cancer Cell Lines and Tumour Samples. [PDF]

J Cell Mol Med
ABSTRACT The cellular uptake of nutrients essential for cell growth and survival is facilitated by solute carrier (SLC) transporters. Members of the SLCO subfamily of SLCs mediate the uptake of substrates relevant to breast cancer (BC), including steroid hormones and anticancer drugs.
Telfer-Sutherland R, Page L, Meeson A, Lowes S.   +3 more
europepmc   +2 more sources

A pediatric patient with chronic enteropathy associated with SLCO2A1 who underwent multimodal treatment including several surgeries: a case report [PDF]

Frontiers in Surgery
IntroductionChronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare protein-losing enteropathy primarily recognized in Asia. Its uncommon nature and limited research usually complicate diagnosis and treatment. This review examines the course of
Yoojin Jung, Jaehee Chung, Inhyuk Yoo
doaj   +2 more sources

Intratumoral <i>Fusobacterium nucleatum</i> Drives Cancer-Associated Fibroblasts Enrichment and Immune Exclusion in Esophageal Squamous Cell Carcinoma. [PDF]

Ann Gastroenterol Surg
Fusobacterium nucleatum contributes to the progression of ESCC by inducing NF‐κB–mediated inflammatory signaling in tumor cells and promoting CAFs activation. Its presence may facilitate immune exclusion and tumor invasion through stromal remodeling. Furthermore, F.
Ofuchi T, Hu Q, Omachi K, Kanemitsu K, Otsu H, Yonemura Y, Tobo T, Baba Y, Iwatsuki M, Mimori K.   +9 more
europepmc   +2 more sources