Results 21 to 30 of about 1,942 (174)

Biological and prognostic insights into the prostaglandin D2 signaling axis in lung adenocarcinoma [PDF]

Frontiers in Pharmacology
BackgroundTumor metabolism reprogramming is a hallmark of cancer, but metabolite-mediated intercellular communication remains poorly understood. To address this gap, we estimated and explored communication events exploring based on single‐cell RNA data ...
Qiang Liu, Huiguo Chen, Dongfang Tang, Huibiao Zhang, Shaogeng Chen, Yiran Meng, Boying Zheng, Fei Liu, Jing Zhou, Wen Zhang   +9 more
doaj   +2 more sources

Crohn-like Disease Affecting Small Bowel Due to Monogenic SLCO2A1 Mutations: First Cases of Chronic Enteropathy Associated with SLCO2A1 Gene [CEAS] in France. [PDF]

J Crohns Colitis, 2023
Abstract Introduction Multiple chronic ulcers of small intestine are mainly ascribed to Crohn’s disease. Among possible differential diagnoses are chronic ulcers of small bowel caused by abnormal activation of the prostaglandin pathway either in the archetypal but uncommon non-steroidal anti ...
Hamon A, Cazals-Hatem D, Stefanescu C, Uzzan M, Treton X, Sauvanet A, Panis Y, Monsinjon M, Bonvalet F, Corcos O, Azouguene E, Cerf-Bensussan N, Bouhnik Y, Charbit-Henrion F.   +13 more
europepmc   +3 more sources

Chronic Enteropathy Associated with <i>SLCO2A1</i> Gene. [PDF]

Inflamm Intest Dis
Background: Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare hereditary disorder characterized by multiple small intestinal ulcers, chronic anemia, and hypoproteinemia. Initially reported by Okabe et al. [J Jpn Soc Gastroenterol. 1968;65:1114–7] in 1968 as chronic nonspecific multiple ulcers of the small intestine, the condition was ...
Umeno J, Esaki M, Uchida K, Matsumoto T.
europepmc   +2 more sources

Inflammatory profiling and immune cell infiltration in dysthyroid optic neuropathy: insights from bulk RNA sequencing [PDF]

Frontiers in Immunology
BackgroundDysthyroid optic neuropathy (DON), the most severe complication of thyroid eye disease (TED), has unclear mechanisms and unsatisfactory treatment outcomes.
Qintao Ma, Yuanping Hai, Yongbo Duan, Genfeng Yu, Cheng Song, ShengAi Huang, Anqi Huang, Yan Zhu, Yongzhi Shen, Zimeng Huang, Xiao Wang, Lan Liu, Thomas Efferth, Huiyu Guo, Yi Wang, Yi Wang, Jie Shen   +16 more
doaj   +2 more sources

Eosinophilic enteritis requiring differentiation from chronic enteropathy associated with SLCO2A1 gene: A case report. [PDF]

World J Gastroenterol, 2023
Eosinophilic gastrointestinal disease (EGID) is a disorder characterized by infiltration of eosinophils causing mucosal damage and dysfunction of the gastrointestinal tract. The endoscopic findings of eosinophilic enteritis (EoN), an EGID variant, are nonspecific and occasionally difficult to diagnose.
Kimura K, Jimbo K, Arai N, Sato M, Suzuki M, Kudo T, Yano T, Shimizu T.   +7 more
europepmc   +3 more sources

Comprehensive evaluation of clinical phenotypes and pathogenic features in late-onset monogenic inflammatory bowel disease: a comparative study with infantile-onset cases [PDF]

BMC Gastroenterology
Background Monogenic inflammatory bowel disease (mIBD) in patients with onset after the age of 16 has been increasingly recognized, but these reports are sporadic and lack a systematic overview, leaving the clinical and genetic characteristics poorly ...
Haoying Liu, Yinxian Shen, Jiaxin Xu, Shangzhan Huang, TingTing Qin, Qi Zhou, Jiazhi Liao, Fang Xiao   +7 more
doaj   +2 more sources

Pathogenesis of chronic enteropathy associated with the SLCO2A1 gene: Hypotheses and conundrums. [PDF]

World J Gastroenterol
Chronic enteropathy associated with the SLCO2A1 gene (CEAS) is a complex gastroenterological condition characterized by multiple ulcers in the small intestine with chronic bleeding and protein loss. This review explores the potential mechanisms underlying the pathogenesis of CEAS, focusing on the role of SLCO2A1 -encoded prostaglandin transporter ...
Xie ZX, Li Y, Yang AM, Wu D, Wang Q.
europepmc   +3 more sources

Paraptosis-related classification and risk signature for prognosis prediction and immunotherapy assessment in gastric cancer [PDF]

Discover Oncology
Background Gastric cancer (GC) poses a significant health threat due to its prevalence and poor prognosis. To improve outcomes, there is an urgent need for novel biomarkers.
Kai Zhou, Ruyue Chen
doaj   +2 more sources

A Novel Chronic Enteropathy Associated with SLCO2A1 Gene Mutation: Enterography Findings in a Multicenter Korean Registry. [PDF]

Korean J Radiol, 2023
Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a recently recognized disease. We aimed to evaluate the enterographic findings of CEAS.Altogether, 14 patients with CEAS were confirmed based on known SLCO2A1 mutations. They were registered in a multicenter Korean registry between July 2018 and July 2021. Nine of the patients (37.2 ± 13 years;
Jeong B, Park SH, Ye BD, Kim J, Yang SK.
europepmc   +3 more sources

Homozygous Missense Variant in the Solute Carrier Organic Anion Transporter 2A1 (SLCO2A1) Gene Underlies Isolated Nail Clubbing. [PDF]

Genes (Basel), 2023
Background: Inherited isolated nail clubbing is a very rare Mendelian condition in humans, characterized by enlargement of the terminal segments of fingers and toes with thickened nails. Mutations in two genes have been reported to cause isolated nail clubbing in humans, which are the SLCO2A1 gene and the HPGD gene.
Umair M, Bilal M, Shah K, Said G, Ahmad F.   +4 more
europepmc   +3 more sources