Molecular cloning and characterization of the porcine prostaglandin transporter (
BMC Genetics, 2009 Background Because prostaglandins are involved in many (patho)physiological processes, SLCO2A1 was already characterized in several species in an attempt to unravel specific processes/deficiencies.
Cox Eric +5 more
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Korean Journal of Radiology, 2023 Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a recently recognized disease. We aimed to evaluate the enterographic findings of CEAS.Altogether, 14 patients with CEAS were confirmed based on known SLCO2A1 mutations. They were registered in a multicenter Korean registry between July 2018 and July 2021. Nine of the patients (37.2 ± 13 years;
Boryeong Jeong +4 more
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Análise dos genes HPGD e SLCO2A1 em pacientes com Paquidermoperiostose
Introdução: A Osteoartropatia hipertrófica primária (PHO) ou Paquidermoperiostose (PDP) é uma doença genética rara que afeta ossos e pele. Casos com variantes alélicas patogênicas (VAP) germinativas nos genes SLCO2A1 e HPGD apresentam padrão de herança ...
Arcanjo, Adriano Miguel
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Slco2a1 deficiency exacerbates experimental colitis via inflammasome activation in macrophages: a possible mechanism of chronic enteropathy associated with SLCO2A1 gene [PDF]
Scientific Reports, 2020 AbstractLoss-of-function mutations in the solute carrier organic anion transporter family, member 2a1 gene (SLCO2A1), which encodes a prostaglandin (PG) transporter, have been identified as causes of chronic nonspecific multiple ulcers in the small intestine; however, the underlying mechanisms have not been revealed.
Nakata, Rieko +17 more
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Regulation of HPGD and SLCO2A1 in Colorectal Cancer Development [PDF]
, 2018 A wide range of lipid mediators are synthesised from Polyunsaturated Fatty Acids. These mediators regulate inflammation and many other processes in the human body, and perturbation of their signalling can contribute to the survival and proliferation of ...
Papagrigoriou, Spyridon
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P752 A nationwide survey of chronic enteropathy associated with SLCO2A1 gene in Japan [PDF]
Journal of Crohn's and Colitis, 2020 Abstract Background Chronic enteropathy associated with SLCO2A1 gene (CEAS) is an autosomal recessive disease caused by mutations in the SLCO2A1 gene which encodes a prostaglandin transporter. It is a rare intractable disease characterised by persistent blood and protein loss due to the small ...
J Umeno +16 more
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소아청소년기에서 SLCO2A1 gene 연관 만성 장병증 (CEAS) 의 임상 양상 [PDF]
, 2022 학위논문(석사) -- 서울대학교대학원 : 의과대학 임상의과학과, 2022.2. 고재성.Background and Aims: The incidence of inflammatory bowel disease (IBD) is increasing worldwide, and many atypical IBDs are being discovered.
임진규
core
Complete form of pachydermoperiostosis in a 16-year-old boy: A case report
Indian Journal of Paediatric Dermatology, 2022 Pachydermoperiostosis is an inherited osseocutaneous disorder. The unusual increased levels of prostaglandin E2 due to mutations in either HPGD gene or SLCO2A1 gene are regarded as the causative factor.
Sahana M Srinivas +3 more
doaj +1 more source
Mutations in theSLCO2A1Gene and Primary Hypertrophic Osteoarthropathy: A Clinical and Biochemical Characterization [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2013 We previously demonstrated that deficiency of the prostaglandin transporter (SLCO2A1) is a cause of primary hypertrophic osteoarthropathy (PHO). However, its clinical and metabolic characteristics have not been well defined.The objective of the study was to expand this mutational spectrum to better delineate the SLCO2A1 deficiency phenotype and ...
Zeng, Zhang +4 more
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