Clinical features of chronic enteropathy associated with SLCO2A1 gene: a new entity clinically distinct from Crohn's disease. [PDF]
J Gastroenterol, 2018 Umeno J +26 more
europepmc +2 more sources
Successful azathioprine treatment in an adolescent with chronic enteropathy associated with SLCO2A1 gene: A case report. [PDF]
Medicine (Baltimore), 2018 Abstract Introduction: Chronic nonspecific multiple ulcers of the small intestine (CNSU), an entity with female preponderance and manifestations including anemia and hypoproteinemia reflecting persistent gastrointestinal bleeding and intestinal protein loss, has been considered idiopathic.
Eda K +5 more
europepmc +3 more sources
Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis. [PDF]
PLoS ONE, 2015 Prostaglandin (PG) E2 exhibits an anti-fibrotic effect in the lung in response to inflammatory reactions and is a high-affinity substrate of PG transporter (SLCO2A1).
Takeo Nakanishi +8 more
doaj +1 more source
Life, 2021 The Maxi-Cl phenotype accounts for the majority (app. 60%) of reports on the large-conductance maxi-anion channels (MACs) and has been detected in almost every type of cell, including placenta, endothelium, lymphocyte, cardiac myocyte, neuron, and glial ...
Ravshan Z. Sabirov +6 more
doaj +1 more source
SLCO2A1 Gene Variant in a Portuguese Patient with Primary Hypertrophic Osteoarthropathy
Portuguese Journal of Pediatrics, 2022 Portuguese Journal of Pediatrics, Vol. 53 No. 3 (2022)
Cardoso, Ivana +4 more
openaire +3 more sources
Atypical primary hypertrophic osteoarthropathy diagnosed with a novel SLCO2A1 gene mutation
Imaging, 2023 AbstractPrimary hypertrophic osteoarthropathy (HOA) is a rare condition with no identifiable cause, accounting for 3%–5% of all HOA cases. It is challenging to identify incomplete primary HOA, which can be misdiagnosed as other hypertrophic periostitis diseases.
Pham Hoai Thu +3 more
openaire +1 more source
Complete form of pachydermoperiostosis in a 16-year-old boy: A case report
Indian Journal of Paediatric Dermatology, 2022 Pachydermoperiostosis is an inherited osseocutaneous disorder. The unusual increased levels of prostaglandin E2 due to mutations in either HPGD gene or SLCO2A1 gene are regarded as the causative factor.
Sahana M Srinivas +3 more
doaj +1 more source
Prostaglandin pathway gene expression in human placenta, amnion and choriodecidua is differentially affected by preterm and term labour and by uterine inflammation [PDF]
, 2014 BACKGROUND: Elucidation of the biochemical pathways involved in activation of preterm and term human labour would facilitate the development of effective management and inform judgements regarding the necessity for preterm tocolysis and post-term ...
Andrés López Bernal +2 more
core +1 more source
Primary hypertrophic osteoarthropathy: genetics, clinical features and management
Frontiers in Endocrinology, 2023 Primary hypertrophic osteoarthropathy (PHO) is a genetic disorder mainly characterized by clubbing fingers, pachydermia and periostosis. Mutations in the HPGD or SLCO2A1 gene lead to impaired prostaglandin E2 (PGE2) degradation, thus elevating PGE2 ...
Qi Lu +4 more
doaj +1 more source
Influence of Genetic Polymorphisms in Prostaglandin E2 Pathway (COX-2/HPGD/SLCO2A1/ABCC4) on the Risk for Colorectal Adenoma Development and Recurrence after Polypectomy [PDF]
, 2016 OBJECTIVES: Deregulation of prostaglandin E2 (PGE2) levels reported in colorectal carcinogenesis contributes to key steps of cancer development. Our aim was to evaluate the influence of the genetic variability in COX-2/HPGD/SLCO2A1/ABCC4 PGE2 pathway ...
Brandão, C. +8 more
core +1 more source