Results 61 to 70 of about 210,575 (315)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Fixed-Time-Convergent Sliding Mode Control with Sliding Mode Observer for PMSM Speed Regulation

Sensors
This paper focuses on the speed control of a permanent magnet synchronous motor (PMSM) for electric drives with model uncertainties and external disturbances.
Xin Zhang, Hongwen Li, Meng Shao
doaj   +1 more source

Improved control strategy for PMSM based on fuzzy sliding mode control and sliding-mode observer

Journal of Measurement Science and Instrumentation, 2021
Aimed at the problems of large torque ripple,obvious chattering and poor estimation accuracy of back-EMFs in traditional permanent magnet synchronous motor（PMSM）control system with sliding mode observer（SMO）,an improved control strategy for PMSM based on
ZHAO Feng, LUO Wen, GAO Fengyang, YU Jiale   +3 more
doaj  

Application of MPC and sliding mode control to IFAC benchmark models [PDF]

, 2008
The comparison of Model Predictive Control (MPC) and Sliding Mode Control (SMC) are presented in this paper. This paper investigates the performance of each controller as the navigation system for IFAC benchmark ship models (cargo vessel and oil tanker)
Anderson, D., McGookin, M., McGookin, E.
core  

H ∞  sliding mode observer design for a class of nonlinear discrete time-delay systems: A delay-fractioning approach

, 2011
Copyright @ 2012 John Wiley & SonsIn this paper, the H ∞  sliding mode observer (SMO) design problem is investigated for a class of nonlinear discrete time-delay systems.
Zidong Wang, Wang, Z, Stergioulas, LK, Jun Hu, Hu, J, Lampros K. Stergioulas, Niu, Y, Yugang Niu   +7 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Multirate Output Feedback based Frequency Shaped Sliding Mode Control

, 2006
This paper proposes a design of frequency shaped sliding mode controller using fast output sampling technique. A compensator is introduced in the sliding surface to attenuate the frequency component of the sliding mode dynamics so that the unmodelled ...
BANDYOPADHYAY, B, B. Bandyopadhyay, A. J. Mehta, MEHTA, AJ, Mehta, A. J., Bandyopadhyay, B.   +5 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Adaptive Non-singular Terminal Sliding Mode Control for DC-DC Converters

Advances in Electrical and Computer Engineering, 2011
DC-DC converters have some inherent characteristics such as high nonlinearity and time-variation, which often result in some difficulties in designing control schemes.
YU, Y., FAN, L.
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source