Results 61 to 70 of about 11,486,483 (290)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Adaptive Non-singular Terminal Sliding Mode Control for DC-DC Converters
Advances in Electrical and Computer Engineering, 2011 DC-DC converters have some inherent characteristics such as high nonlinearity and time-variation, which often result in some difficulties in designing control schemes.
YU, Y., FAN, L.
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Improved fast global sliding mode control based on the exponential reaching law
Advances in Mechanical Engineering, 2017 In order to improve the control performance of the global sliding mode control method, a fast global sliding mode control method is proposed to accelerate the response of the system by changing the exponential decay function in the sliding surface as an ...
Chunbo Xiu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Continuous Adaptive Finite Reaching Time Control and Second-Order Sliding modes [PDF]
, 2013 This paper focuses on the design of adaptive finite reaching time control for first- and second-order dynamic systems with perturbation terms given in a regressive form. The uncertainties considered here are assumed to be bounded with unknown bounds. The
Spurgeon, Sarah K. +3 more
core +1 more source
Towards improving the Statscan X-ray image quality through sliding mode control of the C-arm [PDF]
, 2012 Includes abstract.Includes bibliographical references.This dissertation investigates methods for improving the image quality of a digital radiography system. The Lodox Statscan™ X-ray system provides a full-body scanned image for initial diagnosis.
Esmail, Mohammed
core +1 more source
Advances in Mechanical Engineering, 2017 A disturbance attenuation–based sliding mode control approach with an extended disturbance observer is proposed for systems with mismatched uncertainties. A novel adaptive sliding surface consisting of the disturbance estimation is presented to eliminate
Jianguo Guo +3 more
doaj +1 more source
Journal of Hebei University of Science and Technology, 2018 Airplane control system is a typical multitude input and multitude output (MIMO) nonlinear system with strong coupling and uncertainties, which would increase the controlling difficulty.
Xiaojing WU +3 more
doaj +1 more source