Results 101 to 110 of about 821,881 (278)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Adherence between steel bars and lightweight concrete with EPS beads

Revista IBRACON de Estruturas e Materiais
This paper describes the adherence behavior of a structural lightweight concrete with EPS beads (SLCEB) in a monotonic loading, based in a bibliographic review and in pull-out tests.
A. L. SARTORI, L. M. PINHEIRO, R. M. DA SILVA, S. B. FREITAS, T. G. CESAR   +4 more
doaj   +1 more source

Edge effect factor affecting the tribological properties in water of protrusion surface textures on stainless steel

Biosurface and Biotribology, 2018
Surface textures have been demonstrated to have a positive effect on the friction reduction. However, sharp edges of the normally textured patterns usually cause stress concentration and severe wear during sliding, especially for non-conformal contacting
Xingyang Wu, Zhou Ge, Haozhi Niu, Jingjie Ruan, Jianhua Zhang   +4 more
doaj   +1 more source

Almost-Smooth Histograms and Sliding-Window Graph Algorithms

, 2020
We study algorithms for the sliding-window model, an important variant of the data-stream model, in which the goal is to compute some function of a fixed-length suffix of the stream.
Krauthgamer, Robert, Reitblat, David
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Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Comparison of Perturbed Reynolds Equation and CFD Models for the Prediction of Dynamic Coefficients of Sliding Bearings

Lubricants, 2018
The accuracy and utility of rotordynamic models for machinery systems are greatly affected by the accuracy of the constituent dynamic bearing models.
Troy Snyder, Minel Braun
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The Effect of Water on the Tribological Properties of Aviation Lubricants

Tribology in Industry
The influence of water and ice on the performance properties of lubricants is analysed. The tribotechnical properties of Era VNIINP 286M and AeroShell Grease 33 aviation lithium greases at low temperatures, in the presence of water in the grease, are ...
Tareq M.A. Al-Quraan, Oksana Mikosianchyk, Oleksandr Yakobchuk, Rudolf Mnatsakanov, Andrii Khimko, Ruslan Kostiunik   +5 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Modeling and Lyapunov-designed based on adaptive gain sliding mode control for wind turbines [PDF]

, 2016
In this paper, modeling and the Lyapunov-designed control approach are studied for the Wind Energy Conversion Systems (WECS). The objective of this study is to ensure the maximum energy production of a WECS while reducing the mechanical stress on the ...
Boumediene, Larbi, Djamel Eddine Kerrouche, Kamel, Mezouar, Abdelkader, Van den Bossche, Alex   +3 more
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