Results 121 to 130 of about 217,308 (243)

TNF‐α partially modulates the endothelial dysfunction during the acute phase of Trypanosoma cruzi infection

British Journal of Pharmacology, EarlyView.
Background and Purpose Whereas the effects of Trypanosoma cruzi (T. cruzi) infection are well‐characterised in the heart, its impact on the vasculature has received little attention. In this study, we investigated the effects of acute and chronic T. cruzi infection on vascular responsiveness and the underlying mechanisms.
Thales M. H. Dourado, Wanessa M. C. Awata, Gustavo F. Pimenta, Barbara M. Marchetti, Maiara V. Providello, Sérgio De Albuquerque, Carlos R. Tirapelli   +6 more
wiley   +1 more source

Podocytes: recent biomolecular developments

Biomolecular Concepts, 2014
Podocytes are postmitotic renal glomerular cells with multiple ramifications that extend from the cell body. Processes departing from a podocyte interdigitate with corresponding projections from neighboring cells and form an intricate web that enwraps ...
Armelloni Silvia, Corbelli Alessandro, Giardino Laura, Li Min, Ikehata Masami, Mattinzoli Deborah, Messa Piergiorgio, Pignatari Chiara, Watanabe Shojiro, Rastaldi Maria Pia   +9 more
doaj   +1 more source

Genetic specification of left–right asymmetry in the diaphragm muscles and their motor innervation

eLife, 2017
The diaphragm muscle is essential for breathing in mammals. Its asymmetric elevation during contraction correlates with morphological features suggestive of inherent left–right (L/R) asymmetry.
Camille Charoy, Sarah Dinvaut, Yohan Chaix, Laurette Morlé, Isabelle Sanyas, Muriel Bozon, Karine Kindbeiter, Bénédicte Durand, Jennifer M Skidmore, Lies De Groef, Motoaki Seki, Lieve Moons, Christiana Ruhrberg, James F Martin, Donna M Martin, Julien Falk, Valerie Castellani   +16 more
doaj   +1 more source

Chrysin ameliorates podocyte injury and slit diaphragm protein loss via inhibition of the PERK-eIF2α-ATF-CHOP pathway in diabetic mice

Acta Pharmacologica Sinica, 2017
Glomerular epithelial podocytes are highly specialized cells that play a crucial role in maintaining normal function of the glomerular filtration barrier via their foot processes.
Min-Kyung Kang, Sin-Hye Park, Yun-Ho Kim, Eun‐Jung Lee, L. Antika, Dong Yeon Kim, Yean-Jung Choi, Young‐Hee Kang   +7 more
semanticscholar   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Normal and Dysregulated Sphingolipid Metabolism: Contributions to Podocyte Injury and Beyond

Cells
Podocyte health is vital for maintaining proper glomerular filtration in the kidney. Interdigitating foot processes from podocytes form slit diaphragms which regulate the filtration of molecules through size and charge selectivity. The abundance of lipid
Matthew Tolerico, Sandra Merscher, Alessia Fornoni   +2 more
doaj   +1 more source

Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway [PDF]

, 2017
TRPC6 plays a critical role in proteinuric kidney diseases, and TRPC3 is involved in tubulointerstitialdamage and renal fibrosis in obstructed kidneys. Podocyte loss is a characteristic event in diabetic nephropathy(DN).
Birnbaumer, Lutz, He, Xiju, Li, Shoutian, Liao, Yanhong, Liu, Benju, Xu, Benke   +5 more
core  

BIGRE: a low cross-talk integral field unit tailored for extrasolar planets imaging spectroscopy

, 2009
Integral field spectroscopy (IFS) represents a powerful technique for the detection and characterization of extrasolar planets through high contrast imaging, since it allows to obtain simultaneously a large number of monochromatic images.
Anthony Boccaletti, Bacon, Born, Burrows, Burrows, David Mouillet, Dino Mesa, Enrico Giro, Goodman, Jacopo Antichi, Jean-Luc Beuzit, Kjetil Dohlen, Lafrenière, Lagrange, Lenzen, Marois, Maréchal, Pascal Puget, Perrin, Raffaele G. Gratton, Ren, Riccardo U. Claudi, Sparks, Sudarsky, Sudarsky   +24 more
core   +3 more sources

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, EarlyView.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Pointed telescope subassembly for the UARS High Resolution Doppler Imager [PDF]

The Pointed Telescope Subassembly (PTS) consists of a telescope, its Coude relay optics, a two axis gimbal mechanism, and a cover/caging device. These components, their mechanisms, the requirements, and some of the trade-offs leading to the final design ...
Renken, Robert D.
core   +1 more source