Results 121 to 130 of about 7,412 (180)

The molecular architecture of the kidney slit diaphragm

Abstract Vertebrate life depends on renal function to filter excess fluid and remove low molecular-weight waste products. An essential component of the kidney filtration barrier is the slit diaphragm (SD), a specialized cell-cell junction between podocytes.
Alexandra N. Birtasu, Konstantin Wieland, Utz H. Ermel, Margot P. Scheffer, Florian Grahammer, Achilleas S. Frangakis   +5 more
openaire   +1 more source

Effects of steroid-resistant nephrotic syndrome serum on AA pathway in podocytes cultured in 3D in vitro glomerular model

Scientific Reports
Steroid-resistant nephrotic syndrome (SRNS) is the most severe form of nephrotic syndrome, with genetic or unidentified immunological origins and rapidly progressing to the need for kidney replacement therapy.
Gaia Bianchi, Linda Bellucci, William Morello, Stefano Turolo, Giulia Cricrì, Federico Caicci, Chiara Tamburello, Stefania Villa, Daniele Prati, Giovanni Montini, Federica Collino   +10 more
doaj   +1 more source

Crumbs2 Is an Essential Slit Diaphragm Protein of the Renal Filtration Barrier. [PDF]

J Am Soc Nephrol, 2021
Möller-Kerutt A, Rodriguez-Gatica JE, Wacker K, Bhatia R, Siebrasse JP, Boon N, Van Marck V, Boor P, Kubitscheck U, Wijnholds J, Pavenstädt H, Weide T.   +11 more
europepmc   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science
Focal segmental glomerulosclerosis (FSGS) is a common glomerular lesion that manifests as a primary podocyte injury. Multiple genetic risk factors have been reported to be associated with the development of FSGS.
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
doaj   +1 more source

Phase Separation of MAGI2-Mediated Complex Underlies Formation of Slit Diaphragm Complex in Glomerular Filtration Barrier. [PDF]

J Am Soc Nephrol, 2021
Zhang H, Lin L, Liu J, Pan L, Lin Z, Zhang M, Zhang J, Cao Y, Zhu J, Zhang R.   +9 more
europepmc   +1 more source

Apical-basal polarity regulators are essential for slit diaphragm assembly and endocytosis in Drosophila nephrocytes. [PDF]

Cell Mol Life Sci, 2021
Heiden S, Siwek R, Lotz ML, Borkowsky S, Schröter R, Nedvetsky P, Rohlmann A, Missler M, Krahn MP.   +8 more
europepmc   +1 more source

Phosphorylation of slit diaphragm proteins NEPHRIN and NEPH1 upon binding of HGF promotes podocyte repair. [PDF]

J Biol Chem, 2021
Solanki AK, Arif E, Srivastava P, Furcht CM, Rahman B, Wen P, Singh A, Holzman LB, Fitzgibbon WR, Budisavljevic MN, Lobo GP, Kwon SH, Han Z, Lazzara MJ, Lipschutz JH, Nihalani D.   +15 more
europepmc   +1 more source

Focusing on the Glomerular Slit Diaphragm [PDF]

The American Journal of Pathology, 2002
openaire   +1 more source

Estimation of podocyte dysfunction by nephrinuria severity in proteinuric forms of chronic glomerulonephritis

Терапевтический архив, 2011
Aim. To evaluate severity of nephrinuria (NU) as a marker of podocyte dysfunction (PD) in patients with proteinuric forms of chronic glomerulonephritis (CGN) and to specify efficacy of this test for assessment of activity and prognosis of CGN.
Natal'ya Viktorovna Chebotareva, Irina Nikolaevna Bobkova, Lidiya Vladimirovna Kozlovskaya, Zalina Georgievna Tsopanova, N V Chebotareva, I N Bobkova, L V Kozlovskaya, Z G Tsopanova   +7 more
doaj  

An acytokinetic cell division creates PIP2-enriched membrane asymmetries leading to slit diaphragm assembly in Drosophila nephrocytes.

Development, 2023
Carrasco-Rando M, Culi J, Campuzano S, Ruiz-Gómez M.   +3 more
europepmc   +1 more source