Results 201 to 210 of about 217,308 (243)

Refractory malignant glaucoma after secondary IOL implantation in an eye with 17-year-old vitrectomy: A case report. [PDF]

Medicine (Baltimore)
Sun Z, Ji Z, Liu C, Zhang M, Zhang C, Ren S, Gao L, Liu W.   +7 more
europepmc   +1 more source

The kidney slit diaphragm resembles a fishnet.

Kidney International
INTRODUCTION An essential component of the kidney filtration barrier, the slit diaphragm, is a specialized cell-cell junction composed of the cell adhesion molecules Nephrin and Neph1.
Alexandra N. Birtasu, Konstantin Wieland, U. Ermel, Serena M Arghittu, Sina Manger, Maciej K Kocylowski, Bernd Fakler, M. Scheffer, Roberto Covino, Florian Grahammer, A. Frangakis   +10 more
semanticscholar   +2 more sources

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Synbindin Downregulation Participates in Slit Diaphragm Dysfunction

American Journal of Nephrology, 2021
<b><i>Introduction:</i></b> Synbindin, originally identified as a neuronal cytoplasmic molecule, was found in glomeruli. The cDNA subtractive hybridization technique showed the mRNA expression of synbindin in glomeruli was downregulated in puromycin aminonucleoside (PAN) nephropathy, a mimic of minimal-change nephrotic syndrome.
Veniamin, Ivanov, Yoshiyasu, Fukusumi, Ying, Zhang, Hidenori, Yasuda, Meiko, Kitazawa, Hiroshi, Kawachi   +5 more
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The transcription factor ATF4 mediates endoplasmic reticulum stress related podocyte injury and slit diaphragm defects.

Kidney International, 2022
Mutations in OSGEP and four other genes that encode subunits of the KEOPS complex cause Galloway-Mowat syndrome, a severe, inherited kidney-neurological disease.
Vanessa Krausel, Lisanne Pund, Harald Nüsse, H. Bachir, Andrea Ricker, J. Klingauf, T. Weide, H. Pavenstädt, Michael P. Krahn, D. Braun   +9 more
semanticscholar   +1 more source

Advances in slit diaphragm signaling

Current Opinion in Nephrology and Hypertension, 2014
The podocyte slit diaphragm is a fundamental component of the glomerular filtration barrier and its function is highly dependent on the maintenance of specialized actin-based projections known as foot processes. In this review, we update the function of key slit diaphragm-associated proteins, and introduce some new players and emerging avenues of ...
Laura A, New, Claire E, Martin, Nina, Jones   +2 more
openaire   +2 more sources

Molecular understanding of the slit diaphragm

Pediatric Nephrology, 2012
Glomerular filtration has always attracted the interest of nephrologists and renal researchers alike. Although several key questions on the structure and function of the kidney filter may have been answered within the last 40 years of intense research, there still remain crucial questions to be solved.
Grahammer, Florian, Schell, Christoph, Huber, Tobias B.   +2 more
openaire   +3 more sources

Molecular structure-function relationship in the slit diaphragm

Seminars in Nephrology, 2003
The past 5 years have witnessed an exponential increase in our understanding of the structure and function of the glomerular slit diaphragm. The identification of nephrin as the first transmembrane slit diaphragm protein was a watershed event in slit diaphragm biology.
Sumant S, Chugh, Beenu, Kaw, Yashpal S, Kanwar   +2 more
openaire   +2 more sources

Clinical impact of research on the podocyte slit diaphragm

Nature Clinical Practice Nephrology, 2006
This Review summarizes recent research on the podocyte slit diaphragm. A growing number of molecules that function at the slit diaphragm have been identified in patients with inherited and sporadic nephrotic syndromes. Genetic deletion of nearly all of these molecules results in proteinuria and effacement of foot processes.
Duncan B, Johnstone, Lawrence B, Holzman
openaire   +2 more sources

Slit Diaphragm Junctional Complex and Regulation of the Cytoskeleton

Nephron Experimental Nephrology, 2007
In recent years, identification of proteins found at the slit diaphragm has greatly improved our understanding of the molecular mechanisms responsible for forming and maintaining the glomerular filtration barrier. This review examines the function of proteins identified at the podocyte intercellular junction in coordinating podocyte intercellular ...
Puneet, Garg, Rakesh, Verma, Lawrence B, Holzman   +2 more
openaire   +2 more sources

ER stress and slit diaphragms: is there a connection?

Kidney International, 2023
Galloway-Mowat syndrome is a neurorenal syndrome that has been linked with defective transfer RNA and protein translation caused by variants in the multiprotein complex KEOPS. In the kidney, this syndrome seems to primarily affect the podocytes, but the pathogenesis has remained unclear. In this issue of Kidney International, Krausel et al.
Hermle, Tobias, Simons, Matias
openaire   +3 more sources