Results 211 to 220 of about 217,308 (243)

Intrinsically disordered regions mediate macromolecular assembly of the Slit diaphragm proteins associated with Nephrotic syndrome

Molecular Simulation, 2019
The glomerular filtration barrier (GFB) of the kidney plays an instrumental role in preventing the excretion of large molecules and ensuring the formation of ultra-filtrated urine.
S. K. Mulukala Narasimha, P. Kar, Ramakrishna Vadrevu, A. Pasupulati   +3 more
semanticscholar   +1 more source

Rapid screening of glomerular slit diaphragm integrity in larval zebrafish

American Journal of Physiology-Renal Physiology, 2007
Gene array-type experiments have identified large numbers of genes thought to be important for the integrity of the glomerular slit diaphragm. Confirmation of individual proteins has been limited by the expenses and time involved in generating transgenic or knockout mice for each candidate. We present a functional screening assay based on the clearance
Dirk M, Hentschel, Michael, Mengel, Lisa, Boehme, Fabian, Liebsch, Caroline, Albertin, Joseph V, Bonventre, Hermann, Haller, Mario, Schiffer   +7 more
openaire   +2 more sources

The slit diaphragm: a signaling platform to regulate podocyte function

Current Opinion in Nephrology and Hypertension, 2005
The discovery of nephrin and other slit diaphragm proteins dramatically expanded our knowledge of the molecular make-up of the glomerular filter of the kidney. This review focuses on the most recent evidence elucidating the dynamic functions of the slit diaphragm and stresses the importance of slit diaphragm proteins in mediating signal transduction in
Huber, Tobias B., Benzing, Thomas
openaire   +3 more sources

SIRPα interacts with nephrin at the podocyte slit diaphragm

The FEBS Journal, 2012
The slit diaphragm (SD) is an intercellular junction between renal glomerular epithelial cells (podocytes) that is essential for permselectivity in glomerular ultrafiltration. The SD components, nephrin and Neph1, assemble a signaling complex in a tyrosine phosphorylation dependent manner, and regulate the unique actin cytoskeleton of podocytes ...
Yuko, Kajiho, Yutaka, Harita, Hidetake, Kurihara, Shigeru, Horita, Atsuko, Matsunaga, Haruko, Tsurumi, Shoichiro, Kanda, Noriko, Sugawara, Kenichiro, Miura, Takashi, Sekine, Seisuke, Hattori, Motoshi, Hattori, Takashi, Igarashi   +12 more
openaire   +2 more sources

Role of podocyte slit diaphragm as a filtration barrier.

Nephrology (Carlton, Vic.), 2007
Although the role of glomerular basement membrane has been emphasised as the barrier for retaining plasma proteins in the past three decades, some recent studies have demonstrated that the slit diaphragm of the glomerular epithelial cell (podocyte) is the structure likely to be the barrier in the glomerular capillary wall.
Hiroshi, Kawachi, Naoko, Miyauchi, Koichi, Suzuki, Gi Dong, Han, Michiaki, Orikasa, Fujio, Shimizu   +5 more
openaire   +2 more sources

Slit Diaphragms: Junctions That Never Sleep

Journal of the American Society of Nephrology, 2022
openaire   +2 more sources

In vivo slit diaphragm dynamics in Drosophila

Nature Reviews Nephrology, 2022
openaire   +2 more sources

Confinement-Controlled Aqueous Chemistry within Nanometric Slit Pores

Chemical Reviews, 2021
Daniel Muñoz-Santiburcio
exaly  

Congenital diaphragmatic hernia

Nature Reviews Disease Primers, 2022
Augusto Zani, Wendy Chung, Jan Deprest
exaly  

Quantum mechanical double slit for molecular scattering

Science, 2021
Haowen Zhou, William E Perreault, Nandini Mukherjee   +2 more
exaly