Results 221 to 230 of about 104,390 (258)
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Science Signaling, 2000
The transforming growth factor–β (TGF-β) superfamily of secreted polypeptide growth factors exerts extensive control over all aspects of development and homeostasis, and components of this pathway are often mutated in cancers and in several hereditary disorders.
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The transforming growth factor–β (TGF-β) superfamily of secreted polypeptide growth factors exerts extensive control over all aspects of development and homeostasis, and components of this pathway are often mutated in cancers and in several hereditary disorders.
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TGF‐β signaling: A recap of SMAD‐independent and SMAD‐dependent pathways
Journal of Cellular Physiology, 2021AbstractTransforming growth factor‐β (TGF‐β) is a proinflammatory cytokine known to control a diverse array of pathological and physiological conditions during normal development and tumorigenesis. TGF‐β‐mediated physiological effects are heterogeneous and vary among different types of cells and environmental conditions.
Sabreena Aashaq +5 more
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Smads and chromatin modulation
Cytokine & Growth Factor Reviews, 2005Smad proteins are critical intracellular effector proteins and regulators of transforming growth factor type beta (TGFbeta) modulated gene transcription. They directly convey signals that initiate at ligand-bound receptor complexes and end in the nucleus with changes in programs of gene expression.
Van Grunsven, Leonardus +3 more
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Smad-dependent and Smad-independent pathways in TGF-β family signalling
Nature, 2003Transforming growth factor-beta (TGF-beta) proteins regulate cell function, and have key roles in development and carcinogenesis. The intracellular effectors of TGF-beta signalling, the Smad proteins, are activated by receptors and translocate into the nucleus, where they regulate transcription. Although this pathway is inherently simple, combinatorial
Ying Zhang, Rik Derynck, Derynck Rik
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Cell and Tissue Research, 2011
Transforming growth factor-beta (TGFβ) is a key regulator of cell fate during embryogenesis and has also emerged as a potent driver of the epithelial-mesenchymal transition during tumor progression. TGFβ signals are transduced by transmembrane type I and type II serine/threonine kinase receptors (TβRI and TβRII, respectively). The activated TβR complex
Yabing, Mu +2 more
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Transforming growth factor-beta (TGFβ) is a key regulator of cell fate during embryogenesis and has also emerged as a potent driver of the epithelial-mesenchymal transition during tumor progression. TGFβ signals are transduced by transmembrane type I and type II serine/threonine kinase receptors (TβRI and TβRII, respectively). The activated TβR complex
Yabing, Mu +2 more
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Science's STKE, 2004
The general scheme by which transforming growth factor β (TGF-β) receptors signal to the nucleus is one in which activated receptors cause phosphorylation and activation of Smad proteins, which then accumulate in the nucleus. However, closer inspection reveals that the dynamic behavior of Smad proteins is somewhat more complicated.
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The general scheme by which transforming growth factor β (TGF-β) receptors signal to the nucleus is one in which activated receptors cause phosphorylation and activation of Smad proteins, which then accumulate in the nucleus. However, closer inspection reveals that the dynamic behavior of Smad proteins is somewhat more complicated.
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Characterization of SMAD Phosphorylation and SMAD-Receptor Interaction
2003A, Mehra, L, Attisano, J L, Wrana
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Structural determinants of Smad function in TGF-β signaling
Trends in Biochemical Sciences, 2015Pau Martin-Malpartida +2 more
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