Results 151 to 160 of about 81,731 (259)

Iminostilbene, a Carbamazepine Intermediate, Alleviates Myocardial Fibrosis after Myocardial Infarction via Targeting Galectin3. [PDF]

ACS Pharmacol Transl Sci
Li N, Zhou J, Wang Z, Wang M, Tian Y, Sun G.   +5 more
europepmc   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, Volume 13, Issue 43, 3 August 2026.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Hyperlipidemia-induced metabolic dysregulation impairs tendon homeostasis: the role of TGF-<i>β</i>/Smad2 signaling pathway in lipid-mediated extracellular matrix remodeling. [PDF]

Front Med (Lausanne)
Shang P, Li R, Xia Y, Wang Z, Yang R, Fu Q.   +5 more
europepmc   +1 more source

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, Volume 13, Issue 44, 7 August 2026.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

Clinical significance of microRNA-30d-5p and TGF-β/Smad2 pathway expression levels in polycystic ovary syndrome patients. [PDF]

Am J Transl Res
Qian Y, Zheng N, Liu J, Lu T, Chen Z, Jiang L.   +5 more
europepmc   +1 more source

MicroRNAs in Spinal Cord Injury: Molecular and Translational Insights

Brain and Behavior, Volume 16, Issue 8, August 2026.
MicroRNAs (miRNAs) modulate secondary injury cascades following spinal cord injury (SCI), including inflammation, oxidative stress, apoptosis, and demyelination. Key miRNAs such as miR‐21, miR‐124, miR‐219, and miR‐223 exert neuroprotective effects by regulating astrocytic response, axon regeneration, and remyelination.
Seyyedeh Fahimeh Talebi, Hossein Kalarestaghi, Ehsan Sheikh Hesabi, Saeed Vafaei‐Nezhad   +3 more
wiley   +1 more source

Versatile SMAD2 and SMAD3 epitope-tagged mouse models for genomic profiling of TGFβ signaling: Uncovering GDF9-SMAD2/3 targets. [PDF]

Proc Natl Acad Sci U S A
Liao Z, Zhang Q, Shimada K, Nozawa K, Tang S, Ikawa M, Monsivais D, Matzuk MM.   +7 more
europepmc   +1 more source

Structural Restoration of an Unruptured Vertebral Artery Dissection Following Autologous Mesenchymal Stem Cell Therapy: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Vertebral artery dissection (VAD) is a recognized cause of ischemic stroke, and current management relies on antithrombotic therapy that is not specifically directed at structural repair of the arterial wall. We report a man in his mid‐50s who presented with a sudden, severe right occipital headache after a golf swing and had a history of a ...
Hyungchang Kang, Eung Jae Lee, Moon Hyoung Lee, Hyun Soo Kim   +3 more
wiley   +1 more source

Optimized Aqueous Sedimentation for Methoxyflavone Enrichment from <i>Kaempferia parviflora</i> and Its Mechanistic Suppression of Benign Prostatic Hyperplasia via TGF-β/SMAD/ERK Signaling. [PDF]

ACS Omega
Boonsom T, Uttarawichien T, Nalinratana N, Darai N, Rungrotmongkol T, Rattanakrajang P, Zierau O, Kengtong S, Towiwat P, Sukrong S.   +9 more
europepmc   +1 more source

SMAD4 Expression and Its Association With Treatment Resistance and Clinical Outcomes in Oral Squamous Cell Carcinoma Treated With Preoperative Chemoradiotherapy

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Small mothers against decapentaplegic homologue 4 (SMAD4) plays an important role in transforming growth factor (TGF)‐β signaling and is associated with various cancers. However, little is known about SMAD4 expression in oral squamous cell carcinoma (OSCC).
Junki Sakata, Akiyuki Hirosue, Ryoji Yoshida, Yuichiro Matsuoka, Yusei Todoroki, Hidetaka Arita, Hikaru Nakashima, Tatsuro Yamamoto, Nozomu Takahashi, Masatoshi Hirayama, Kenta Kawahara, Ryo Toya, Ryuji Murakami, Takaaki Ito, Yoshikazu Kuwahara, Hideki Nakayama   +15 more
wiley   +1 more source